MedPath

Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Dexmedetomidine Versus Clonidine for Transversus Abdominis Plane Block in Patients Undergoing Elective Caesarean Section

Not Applicable
Completed
Conditions
Postoperative Pain
Interventions
Drug: bupivacaine
Drug: placebo
Drug: Dexmedetomidine
Drug: clonidine
First Posted Date
2018-12-10
Last Posted Date
2020-08-05
Lead Sponsor
Aswan University Hospital
Target Recruit Count
150
Registration Number
NCT03770013
Locations
🇪🇬

Aswan University, Aswan, Egypt

Dexmedetomidine for Prolonged Sedation in PICUs

Completed
Conditions
Prolonged Sedation
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-12-03
Last Posted Date
2019-01-23
Lead Sponsor
Azienda Ospedaliera di Padova
Target Recruit Count
163
Registration Number
NCT03760978
Locations
🇮🇹

Terapia Intensiva Pediatrica Azienda Ospedaliera di Padova, Padova, Italy

🇮🇹

Pediatric Intensive Care Unit, A.Gemelli Hospital, Sacro Cuore Catholic University, Rome Italy, Rome, Italy

🇮🇹

Pediatric Intensive Care Unit, Children's Hospital C.Arrigo, Alessandria, Italy, Alessandria, Italy

and more 6 locations

The Influence of Dexmedetomidine Hypnosis on Cerebrospinal Fluid (CSF) Volume, Brain Diffusion and 'Stiffness' Characteristics.

Early Phase 1
Withdrawn
Conditions
Cerebrospinal Fluid Pressure Increased
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-11-29
Last Posted Date
2022-05-31
Lead Sponsor
Yale University
Registration Number
NCT03757897

Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery

Not Applicable
Recruiting
Conditions
Pain, Postoperative
Obesity
Interventions
Drug: Remifentanil
Drug: Dexmedetomidine
Behavioral: Person-centred care (PCC)
Drug: Desflurane
Drug: Propofol
Drug: Esketamine
Drug: Oxycodone
Drug: Lidocaine
Device: Transcutaneous Nerve Stimulation (TENS)
First Posted Date
2018-11-28
Last Posted Date
2024-10-14
Lead Sponsor
Göteborg University
Target Recruit Count
220
Registration Number
NCT03756961
Locations
🇸🇪

Lindesberg Hospital, Lindesberg, Region Örebro, Sweden

🇸🇪

Sahlgrenska University hospital/ Östra hopsital, Gothenburg, VG, Sweden

Comparison of Procedural Sedation With Propofol and Dexmedetomidine During Transcatheter Aortic Valve Implantation

Phase 4
Completed
Conditions
Transcatheter Aortic Valve Replacement
Procedural Sedation
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2018-11-20
Last Posted Date
2023-05-10
Lead Sponsor
University Medical Centre Ljubljana
Target Recruit Count
70
Registration Number
NCT03747432
Locations
🇸🇮

UMC Ljubljana, Ljubljana, Slovenia

Dexmedetomidine Use for Sedation in Patients Submitted to Tracheal Surgery

Completed
Conditions
Postoperative Sedation
First Posted Date
2018-10-29
Last Posted Date
2019-01-11
Lead Sponsor
University of Roma La Sapienza
Target Recruit Count
14
Registration Number
NCT03723538
Locations
🇮🇹

azienda ospedaliero universitaria Sant'Andrea, Roma, Italy

Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study

Early Phase 1
Completed
Conditions
Vascular Diseases
Interventions
Other: Increased venous pressure
Drug: Clevidipine
Other: tetanic stimulus
Drug: Phenylephrine
Drug: Dexmedetomidine
Drug: Calcium Chloride
First Posted Date
2018-10-25
Last Posted Date
2022-06-30
Lead Sponsor
University of California, San Francisco
Target Recruit Count
40
Registration Number
NCT03719001
Locations
🇺🇸

University of California San Francisco, San Francisco, California, United States

A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

Phase 2
Completed
Conditions
Adenoid Hypertrophy
Interventions
Drug: Dextromethorphan
Drug: Acetaminophen
Drug: Dexmedetomidine
Drug: Ketamine
First Posted Date
2018-10-22
Last Posted Date
2021-02-05
Lead Sponsor
Arlyne Thung
Target Recruit Count
10
Registration Number
NCT03714919
Locations
🇺🇸

Nationwide Children's Hospital, Columbus, Ohio, United States

Effect of Topical Dexmedetomidine on Intraocular Pressure

Phase 4
Completed
Conditions
Intraocular Pressure
Glaucoma
Interventions
Drug: Balanced salt solution
Drug: Dexmedetomidine
First Posted Date
2018-10-01
Last Posted Date
2018-10-03
Lead Sponsor
Beirut Eye Specialist Hospital
Target Recruit Count
49
Registration Number
NCT03690622
Locations
🇱🇧

Beirut Eye Specialist Hospital, Beirut, Lebanon

Thoracic Paravertebral Blocks Using a Combination of Ropivacaine and Dexmedetomidine

Phase 4
Withdrawn
Conditions
Thoracic Paravertebral Blocks
Interventions
Drug: Dexmedetomidine
First Posted Date
2018-09-19
Last Posted Date
2021-11-12
Lead Sponsor
China Medical University, China
Registration Number
NCT03677115
Locations
🇨🇳

the First Hospital of China Medical University, Shenyang, Liaoning, China

© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy