Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine and Propofol for Pediatric MRI Sedation

Phase 4

Completed

Conditions: Abdominal Neoplasm
Spine Deformity
Neurofibromatoses
Headache
Tumor
Hydrocephalus
Seizure Disorder

Interventions: Drug: propofol
Drug: Lidocaine 1% Injectable Solution
Drug: Dexmedetomidine
Drug: Nitrous Oxide
Drug: Glycopyrrolate
Drug: Sevoflurane

First Posted Date: 2018-05-02

Last Posted Date: 2020-02-21

Lead Sponsor: Medical College of Wisconsin

Target Recruit Count: 40

Registration Number: NCT03513757

Locations: 🇺🇸
Children's Hospital of Wisconsin, Milwaukee, Wisconsin, United States

Combination Effects of Pregabalin and Dexmedetomidine on Postoperative Pain

Phase 4

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Pregabalin and dexmedetomidine
Other: Placebo
Drug: Dexmedetomidine
Drug: Pregabalin

First Posted Date: 2018-05-01

Last Posted Date: 2018-05-01

Lead Sponsor: Wonkwang University Hospital

Target Recruit Count: 150

Registration Number: NCT03512574

Locations: 🇰🇷
WonwangUH, Iksan, Jeonbuk, Korea, Republic of

the Influence of Sleep Improvement Through Different Methods on Patients in ICU

Not Applicable

Conditions: Sleep
Metabolic Problems

Interventions: Device: eye patch
Drug: Dexmedetomidine

First Posted Date: 2018-03-29

Last Posted Date: 2018-03-29

Lead Sponsor: Chinese Medical Association

Target Recruit Count: 120

Registration Number: NCT03480789

Locations: 🇨🇳
The Affliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China

Efficacy of Dexmedetomidine Versus Clonidine to Control Delirium in Patients Undergoing CABG

Not Applicable

Completed

Conditions: Delirium on Emergence

Interventions: Drug: Dexmedetomidine
Drug: Clonidine

First Posted Date: 2018-03-27

Last Posted Date: 2019-07-11

Lead Sponsor: Ain Shams University

Target Recruit Count: 147

Registration Number: NCT03477994

Locations: 🇪🇬
Ain Shams university, Cairo, Egypt

Comparison of Intra-articular Dexmedetomidine and Magnesium in Postoperative Pain

Phase 4

Completed

Conditions: Postoperative Pain
Dexmedetomidine
Intra-articular Injection
Magnesium Sulfate

Interventions: Drug: Precedex
Drug: Magnesium Sulfate

First Posted Date: 2018-03-27

Last Posted Date: 2018-11-13

Lead Sponsor: Derince Training and Research Hospital

Target Recruit Count: 62

Registration Number: NCT03479216

Locations: 🇹🇷
Derince Training and Research Hospital, Kocaeli, Derince, Turkey

Dexmedetomidine After Cardiac Surgery for Prevention of Delirium

Phase 3

Completed

Conditions: ICU Delirium

Interventions: Drug: Sodium chloride 0.9%
Drug: Dexmedetomidine

First Posted Date: 2018-03-26

Last Posted Date: 2022-06-22

Lead Sponsor: University Hospital, Brest

Target Recruit Count: 348

Registration Number: NCT03477344

Locations: 🇫🇷
Hôpital Privé Jacques Cartier, Massy, France
🇫🇷
Angers university hospital, Angers, France
🇫🇷
CHU de Grenoble, Grenoble, France

and more 6 locations

The Effect of Dexmedetomidine on Postoperative Quality of Recovery

Phase 4

Conditions: The Effect of Dexmedetomidine on Postoperative Quality of Recovery

Interventions: Drug: Dexmedetomidine

First Posted Date: 2018-03-16

Last Posted Date: 2019-02-15

Lead Sponsor: Kyungmi Kim

Target Recruit Count: 90

Registration Number: NCT03468062

Locations: 🇰🇷
Gil Medical Center, Gachon University College of Medicine, Incheon, Korea, Republic of

Propofol Versus the Use of Dexmedetomidine as a Sedative Agent for Colonosopy

Phase 3

Conditions: Colonic Diseases

Interventions: Drug: Dexmedetomidine
Drug: Propofol

First Posted Date: 2018-03-15

Last Posted Date: 2018-03-15

Lead Sponsor: Tanta University

Target Recruit Count: 100

Registration Number: NCT03466632

Locations: 🇪🇬
Sameh Abdelkhalek Ahmed, Zagazig, Egypt

IN Dexmedetomidine for Procedural Sedation in Pediatric Closed Reductions for Distal Forearm Fractures

Early Phase 1

Conditions: Conscious Sedation
Distal Radius Fracture

Interventions: Drug: Ketamine
Drug: Dexmedetomidine

First Posted Date: 2018-03-15

Last Posted Date: 2018-03-15

Lead Sponsor: Phoenix Children's Hospital

Target Recruit Count: 40

Registration Number: NCT03466242

Locations: 🇺🇸
Phoenix Children's Hospital, Phoenix, Arizona, United States

Evaluation of the Analgesic Effect of Dexmedetomidine Versus Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries

Not Applicable

Completed

Conditions: Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries

Interventions: Drug: Dexmedetomidine
Drug: Bupivacaine
Drug: Fentanyl

First Posted Date: 2018-03-13

Last Posted Date: 2018-05-30

Lead Sponsor: Cairo University

Target Recruit Count: 60

Registration Number: NCT03463083

Locations: 🇪🇬
Ahmed Abdalla Mohamed, Cairo, Egypt

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