MedPath

Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Sedation Protocols and Skeletal Muscle Metabolism in Mechanical Ventilated Patients

Not Applicable
Conditions
Hypercatabolism
Sedative, Hypnotic, or Anxiolytic Use Disorders
Interventions
Drug: Dexmedetomidine
Drug: Midazolam
First Posted Date
2018-01-18
Last Posted Date
2018-03-29
Lead Sponsor
Chinese Medical Association
Target Recruit Count
360
Registration Number
NCT03402113
Locations
🇨🇳

The Affliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China

Controlled Sedation for Cataract Surgery

Phase 4
Terminated
Conditions
Failed Conscious Sedation During Procedure
Interventions
Drug: remifentanil
Drug: Dexmedetomidine
First Posted Date
2018-01-17
Last Posted Date
2018-01-17
Lead Sponsor
Fundación Universitaria de Ciencias de la Salud
Target Recruit Count
98
Registration Number
NCT03401606

The Diversity of Intestinal Microbiota in Patients With Different Sedative-hypnotics Undergoing Mechanical Ventilation

Not Applicable
Withdrawn
Conditions
Mechanical Ventilation
Intestinal Microbiota
Interventions
Device: Mechanical Ventilation
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2018-01-17
Last Posted Date
2021-09-28
Lead Sponsor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Registration Number
NCT03401736
Locations
🇨🇳

Shanghai9 Hospital, Shanghai, Shanghai, China

Bispectral Index(BIS) on Depth of Sedation With Dexmedetomidine, Propofol and Midazolam During Spinal Anesthesia

Not Applicable
Conditions
Anesthesia, Spinal
Sedation
Interventions
Drug: Propofol
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2018-01-16
Last Posted Date
2018-01-16
Lead Sponsor
Hallym University Medical Center
Target Recruit Count
45
Registration Number
NCT03399019
Locations
🇰🇷

Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Korea, Republic of

Comparing in Dexmedetomidine With po/pr Midazolam for Procedural Sedation in the Pediatric Emergency Department

Phase 4
Withdrawn
Conditions
Procedural Anxiety
Emergencies
Interventions
Drug: Dexmedetomidine
Drug: Midazolam
First Posted Date
2018-01-16
Last Posted Date
2022-09-30
Lead Sponsor
Insel Gruppe AG, University Hospital Bern
Registration Number
NCT03399838

Remifentanil Versus Dexmedetomidine for Post-Cardiac Surgery Patients With Noninvasive Ventilation Intolerance

Completed
Conditions
Cardiac Surgery
Interventions
Drug: Remifentanil
Drug: Dexmedetomidine
First Posted Date
2018-01-10
Last Posted Date
2019-11-29
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
90
Registration Number
NCT03395886
Locations
🇨🇳

Zhongshan hospital, Fudan university, Shanghai, Shanghai, China

Comparison of Midazolam or Dexmedetomidine on Epileptiform EEG During Sevoflurane Mask Induction

Phase 4
Conditions
Inhalation Anesthesia
Interventions
Drug: Placebos
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2018-01-09
Last Posted Date
2018-09-25
Lead Sponsor
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Target Recruit Count
45
Registration Number
NCT03394430
Locations
🇨🇳

Shanghai Ninth People's Hospital,Affililated to Shanghai Jiaotong University School of Medicine, Shanghai, China

Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study

Phase 4
Conditions
Anesthesia
Interventions
Drug: Fentanyl infusion
Procedure: Ultrasound guided TAP block
Drug: Dexmedetomidine
First Posted Date
2018-01-09
Last Posted Date
2018-01-09
Lead Sponsor
Ain Shams University
Target Recruit Count
20
Registration Number
NCT03393988
Locations
🇪🇬

Hospitals of Faculty of Medicine , Ain Shams University, Cairo, Egypt

Comparison of the Effect of Intravenous and Perineural Dexmedetomidine in Gastric Cancer Surgery

Not Applicable
Conditions
Gastric Cancer
Pain, Postoperative
Interventions
Drug: Dexmedetomidine
Drug: 0.9% Sodium-chloride
First Posted Date
2018-01-08
Last Posted Date
2018-01-12
Lead Sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Target Recruit Count
90
Registration Number
NCT03393403
Locations
🇨🇳

Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

Dexmedetomidine and Swallowing Function

Phase 4
Conditions
Deglutition
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2018-01-05
Last Posted Date
2018-01-05
Lead Sponsor
Region Örebro County
Target Recruit Count
20
Registration Number
NCT03390972
© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy