MedPath

Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-

The Effects of Different Anesthetics on Functional Connectivity

Not Applicable
Recruiting
Conditions
Sedation
Interventions
First Posted Date
2017-11-17
Last Posted Date
2024-08-01
Lead Sponsor
Beijing Tiantan Hospital
Target Recruit Count
240
Registration Number
NCT03343873
Locations
🇨🇳

Beijing Tian Tan Hospital, Beijing, China

Comparison of Dexmedetomidine and Midazolam for Prevention of Emergence Delirium in Children

Not Applicable
Completed
Conditions
Tonsillitis
Interventions
First Posted Date
2017-11-09
Last Posted Date
2019-01-09
Lead Sponsor
Eunah Cho, MD
Target Recruit Count
70
Registration Number
NCT03337672
Locations
🇰🇷

Kangbuk Samsung Hospital, Seoul, Korea, Republic of

Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric

Phase 4
Conditions
Pediatrics
Dexmedetomidine
Pharmacodynamics
Pharmacokinetics
Interventions
First Posted Date
2017-11-09
Last Posted Date
2017-11-09
Lead Sponsor
Chinese Medical Association
Target Recruit Count
187
Registration Number
NCT03337581
Locations
🇨🇳

The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients

Phase 4
Completed
Conditions
Aged
Intensive Care Units
Mechanical Ventilation Complication
Sleep Disorders
Dexmedetomidine
Postoperative Period
Interventions
Drug: Placebo (normal saline)
Drug: Dexmedetomidine
First Posted Date
2017-11-07
Last Posted Date
2019-12-11
Lead Sponsor
Peking University First Hospital
Target Recruit Count
80
Registration Number
NCT03335527
Locations
🇨🇳

Peking University First Hospital, Beijing, Beijing, China

Pharmacokinetics and Dynamics of Dexmedetomidine as Adjuvant in TAP Block

Phase 2
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2017-11-01
Last Posted Date
2020-10-22
Lead Sponsor
Assiut University
Target Recruit Count
24
Registration Number
NCT03328299
Locations
🇪🇬

South Egypt Cancer instIitute, Assuit, Egypt

Effect of Dexmedetomidine on Renal Function and Delayed Graft Function After Kidney Transplantation

Not Applicable
Conditions
Kidney Transplantation
Interventions
First Posted Date
2017-10-31
Last Posted Date
2019-01-15
Lead Sponsor
Yonsei University
Target Recruit Count
104
Registration Number
NCT03327389
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal Surgery

Phase 4
Completed
Conditions
Chronic Pain
Interventions
Other: Placebo Saline
Drug: Dexmedetomidine
First Posted Date
2017-10-30
Last Posted Date
2023-06-05
Lead Sponsor
NYU Langone Health
Target Recruit Count
83
Registration Number
NCT03325972
Locations
🇺🇸

New York University School of Medicine, New York, New York, United States

Thoracic Spinal Versus Epidural Anesthesia for Nephrectomy in Obstructive/Restrictive Lung Disease Patients

Not Applicable
Completed
Conditions
Nephrectomy
Anesthesia
Lung Diseases
Interventions
Procedure: Thoracic Spinal Anesthesia
Procedure: Thoracic Epidural Anesthesia
Drug: Bupivacaine 0.5% (hyperbaric)
Drug: Bupivacaine 0.5% (isobaric)
Drug: Fentanyl
Drug: Dexmedetomidine
First Posted Date
2017-10-27
Last Posted Date
2019-07-23
Lead Sponsor
Nazmy Edward Seif
Target Recruit Count
60
Registration Number
NCT03324490
Locations
🇪🇬

Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt

Pharmacokinetics of Different Mode Administration of Intranasal Dexmedetomidine

Phase 3
Completed
Conditions
Dexmedetomidine
Bioavailability
Interventions
First Posted Date
2017-10-27
Last Posted Date
2017-10-27
Lead Sponsor
The University of Hong Kong
Target Recruit Count
8
Registration Number
NCT03323593
Locations
🇭🇰

Queen Mary Hospital, Hong Kong, Hong Kong

Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)

Phase 3
Completed
Conditions
Delirium
Agitation
Interventions
Other: Placebo
Drug: Dexmedetomidine
First Posted Date
2017-10-23
Last Posted Date
2023-02-24
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
151
Registration Number
NCT03317067
Locations
🇫🇷

CHU Clermont-Ferrand, Clermont-Ferrand, France

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