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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Postoperative and Opioid Free Anesthesia

Phase 3
Terminated
Conditions
Anesthesia
Opioid-Related Disorders
Interventions
Drug: Remifentanil
Drug: Dexmedetomidine
First Posted Date
2017-10-20
Last Posted Date
2019-10-18
Lead Sponsor
Rennes University Hospital
Target Recruit Count
316
Registration Number
NCT03316339
Locations
🇫🇷

Beaujon Hospital, Clichy, France

🇫🇷

Nimes University Hospital, Nîmes, France

🇫🇷

Saint-Brieuc Hospital, Saint-Brieuc, France

and more 8 locations

the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting

Conditions
Post Operative Nausea and Vomiting
Interventions
Drug: Dexmedetomidine
First Posted Date
2017-10-18
Last Posted Date
2017-10-18
Lead Sponsor
Cairo University
Target Recruit Count
75
Registration Number
NCT03313479
Locations
🇪🇬

Cairo University, Cairo, Giza, Egypt

Comparing Dexmedetomidine With Bupivacaine Versus Bupivacaine Alone for Caudal Block in Supra - Umbilical Surgeries

Phase 2
Completed
Conditions
Anesthesia
Interventions
Drug: Dexmedetomidine
Drug: Bupivacaine
First Posted Date
2017-10-11
Last Posted Date
2018-07-17
Lead Sponsor
Cairo University
Target Recruit Count
24
Registration Number
NCT03307590
Locations
🇪🇬

Cairo University, Cairo, Egypt

Dexmedetomidine, Ketamine and Dexmetedomidine-Ketamine Combination for Control of Shivering During Regional Anaethesia

Phase 4
Completed
Conditions
Shivering
Interventions
Drug: Dexmedetomidine
Drug: ketamine
Drug: Dexmetedomidine+Ketamine
First Posted Date
2017-10-05
Last Posted Date
2018-07-03
Lead Sponsor
Assiut University
Target Recruit Count
94
Registration Number
NCT03302351
Locations
🇪🇬

Ghada Mohammmad Aboalfadl, Assiut, Egypt

Polypharmacy-related Adverse Events in Critically Ill Children

Phase 2
Withdrawn
Conditions
Delirium
Interventions
Drug: Dexmedetomidine
Drug: Fentanyl
First Posted Date
2017-09-26
Last Posted Date
2019-07-18
Lead Sponsor
Duke University
Registration Number
NCT03293927
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study

Phase 4
Completed
Conditions
Unconsciousness
Consciousness
Interventions
Drug: Dexmedetomidine
Drug: Ketamine
Drug: Propofol
Drug: Midazolam
First Posted Date
2017-09-15
Last Posted Date
2023-04-13
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
35
Registration Number
NCT03284307
Locations
🇺🇸

UW Hospital and Clinics, Madison, Wisconsin, United States

Deep Brain Stimulation (DBS) Sedation

Phase 4
Terminated
Conditions
Brain
Sedation
Interventions
Drug: Propofol
Drug: Dexmedetomidine
Drug: Remifentanil
First Posted Date
2017-09-14
Last Posted Date
2024-07-05
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
20
Registration Number
NCT03283150
Locations
🇺🇸

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines

Not Applicable
Completed
Conditions
Anesthesia; Reaction
Interventions
Drug: Saline
Drug: Lidocaine
Drug: Dexmedetomidine
Drug: Lidocaine plus Dexmedetomidine
First Posted Date
2017-09-08
Last Posted Date
2022-03-10
Lead Sponsor
Anqing Municipal Hospital
Target Recruit Count
160
Registration Number
NCT03276533
Locations
🇨🇳

Department of Anqing Hospital Anesthesiology, Anqing, Anhui, China

Dexmedetomidine for Prevention of Chronic Postoperative Pain

Phase 4
Conditions
Chronic Postoperative Pain
Interventions
Drug: saline
Drug: dexmedetomidine
First Posted Date
2017-09-07
Last Posted Date
2017-12-05
Lead Sponsor
Zhongda Hospital
Target Recruit Count
120
Registration Number
NCT03275207
Locations
🇨🇳

Zhongda Hospital, Nanjing, Jiangsu, China

Intravenous Dexmedetomidine, Dexamethasone and Interscalene Block Duration After Arthroscopic Shoulder Surgery

Phase 4
Completed
Conditions
Shoulder Joint Disorder
Ambulatory Surgical Procedures
Pain, Postoperative
Brachial Plexus Block
Interventions
Drug: Dexamethasone
Drug: Dexmedetomidine
First Posted Date
2017-09-01
Last Posted Date
2019-04-16
Lead Sponsor
University of Manitoba
Target Recruit Count
198
Registration Number
NCT03270033
Locations
🇨🇦

Pan Am Surgical Centre, Winnipeg, Manitoba, Canada

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