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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients

Phase 4
Suspended
Conditions
Intensive Care Unit Syndrome
Dexmedetomidine
Adult Disease
Mechanical Ventilation Complication
Delirium
Interventions
Drug: Placebo (normal saline)
Drug: Dexmedetomidine
First Posted Date
2017-06-01
Last Posted Date
2022-04-26
Lead Sponsor
Peking University First Hospital
Target Recruit Count
260
Registration Number
NCT03172897
Locations
🇨🇳

Peking University First Hospital, Beijing, Beijing, China

Premedication With Intranasal Dexmedetomidine or Midazolam for Prevention of Emergence Agitation in Children

Phase 3
Completed
Conditions
Emergence Delirium
Interventions
Drug: Dexmedetomidine
Drug: Midazolam oral solution
Drug: Oral saline
Drug: Nasal saline
First Posted Date
2017-05-31
Last Posted Date
2018-07-13
Lead Sponsor
Brasilia University Hospital
Target Recruit Count
22
Registration Number
NCT03171740
Locations
🇧🇷

University Hospital of Brasilia University, Brasilia, Distrito Federal, Brazil

Effects of Dexmedetomidine and Dopamine on Renal Function After Major Surgery

Phase 4
Conditions
Renal Function
Interventions
Drug: Dexmedetomidine
Drug: Dopamine
First Posted Date
2017-05-31
Last Posted Date
2018-06-12
Lead Sponsor
Tao Zhang
Target Recruit Count
180
Registration Number
NCT03170739
Locations
🇨🇳

First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Dexmedetomidine and the Inflammatory Response in Pediatric Cardiac Surgery

Phase 2
Conditions
Cardiac Surgical Procedures
Interventions
Drug: Dexmedetomidine
Drug: Normal saline
First Posted Date
2017-05-23
Last Posted Date
2018-07-09
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03163238
Locations
🇪🇬

Faculty of Medicine, Assiut, Egypt

The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

Not Applicable
Conditions
Coronary Artery Bypass, Off-Pump
Interventions
Drug: dexmedetomidine
Other: normal saline
First Posted Date
2017-05-23
Last Posted Date
2017-05-23
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
40
Registration Number
NCT03163693
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Phase 4
Completed
Conditions
Endometrial Adenocarcinoma
Interventions
Drug: Ketamine
Drug: dexmedetomidine
Drug: bupivacaine
First Posted Date
2017-05-23
Last Posted Date
2020-01-22
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03164590
Locations
🇪🇬

South Egypt Cancer instIitute, Assuit, Egypt

Transversus Abdominis Plane Block Using Dexmedetomidine and Bupivacaine

Phase 2
Completed
Conditions
Laparoscopic Orcheopexy
Interventions
Drug: Bupivacaine
Drug: Dexmedetomidine
First Posted Date
2017-05-17
Last Posted Date
2018-09-24
Lead Sponsor
Assiut University
Target Recruit Count
80
Registration Number
NCT03156296
Locations
🇪🇬

Assiut University Hospital, Assiut, Egypt

Dexmedetomidine Versus Clonidine in TAP Block

Phase 2
Completed
Conditions
Transversus Abdominis Plane Block
Interventions
Drug: Dexmedetomidine
Drug: Clonidine
Drug: Levobupivacaine
First Posted Date
2017-05-16
Last Posted Date
2020-08-20
Lead Sponsor
Assiut University
Target Recruit Count
90
Registration Number
NCT03155646
Locations
🇪🇬

Assiut University Hospital, Assiut, Egypt

Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients

Phase 3
Conditions
Septic Shock
Interventions
Drug: Dexmedetomidine
First Posted Date
2017-05-12
Last Posted Date
2018-01-24
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT03151668

Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care

Phase 3
Terminated
Conditions
Sedation
Analgesia
Anxiolysis
Interventions
Drug: Opioids
Drug: Dexmedetomidine
Drug: Placebo
First Posted Date
2017-05-12
Last Posted Date
2021-07-28
Lead Sponsor
Walid HABRE
Target Recruit Count
33
Registration Number
NCT03151863
Locations
🇨🇭

University Hospitals of Geneva, Geneva, Switzerland

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