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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Pharmacodynamic Interaction of REMI and DMED

Phase 4
Completed
Conditions
Anesthesia
Interventions
Drug: Dexmedetomidine
Drug: Remifentanil
First Posted Date
2017-05-08
Last Posted Date
2024-04-18
Lead Sponsor
University Medical Center Groningen
Target Recruit Count
30
Registration Number
NCT03143972
Locations
🇳🇱

University Medical Center Groningen, Groningen, Netherlands

Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy

Phase 4
Completed
Conditions
Colonoscopy
Interventions
Drug: Dexmedetomidine
Other: Saline placebo
Drug: Propofol
First Posted Date
2017-05-03
Last Posted Date
2019-07-29
Lead Sponsor
State University of New York - Downstate Medical Center
Target Recruit Count
122
Registration Number
NCT03139279
Locations
🇺🇸

SUNY Downstate Medical Center, Brooklyn, New York, United States

The Epigenetic Modification in OPRM1 on Postoperative Analgesia and Side Effect Induced by Sufentanil

First Posted Date
2017-05-01
Last Posted Date
2017-05-01
Lead Sponsor
Huazhong University of Science and Technology
Target Recruit Count
100
Registration Number
NCT03135795
Locations
🇨🇳

Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Dexmedetomidine Reduces Emergence Delirium in Children Undergoing Tonsillectomy With Propofol Anesthesia

Phase 2
Completed
Conditions
Emergence Delirium
Blood Pressure
Extubation Time
Postoperative Analgesia
Heart Rate
Interventions
Drug: Normal saline
Drug: Dexmedetomidine
Device: Bispectral index
Device: Train of four ratio
First Posted Date
2017-04-27
Last Posted Date
2018-07-09
Lead Sponsor
Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
Target Recruit Count
60
Registration Number
NCT03131375
Locations
🇬🇷

Childrens Hospital P. and A. Kyriakou Anesthesiology Department, Athens, Greece

Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough

Phase 1
Conditions
Fentanyl-induced Cough
Interventions
Drug: Dexmedetomidine
First Posted Date
2017-04-24
Last Posted Date
2017-07-05
Lead Sponsor
Yangzhou University
Target Recruit Count
240
Registration Number
NCT03126422
Locations
🇨🇳

the Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China

Comparison of Opioid Based and Opioid Free Anaesthesia in Transsphenoidal Surgery

Not Applicable
Completed
Conditions
Opioid Free Anaesthesia
Interventions
Drug: Fentanyl
Drug: Dexmedetomidine
Drug: Ketamine
Drug: Placebos
First Posted Date
2017-04-19
Last Posted Date
2019-07-08
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
60
Registration Number
NCT03120234
Locations
🇮🇳

Post graduation institute of medical education and research, Chandigarh, India

Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia

Not Applicable
Conditions
Postoperative Delirium
Interventions
Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl
First Posted Date
2017-04-19
Last Posted Date
2021-09-21
Lead Sponsor
Mahidol University
Target Recruit Count
600
Registration Number
NCT03120442
Locations
🇹🇭

Siriraj Hospital, Bangkok noi, Bangkok, Thailand

Impact of Dexmedetomidine on Sleep Quality

Phase 4
Completed
Conditions
Elderly
Surgery
Analgesia
Dexmedetomidine
Complication,Postoperative
Sleep Quality
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2017-04-18
Last Posted Date
2021-02-10
Lead Sponsor
Peking University First Hospital
Target Recruit Count
118
Registration Number
NCT03117790
Locations
🇨🇳

Peking University First Hospital, Beijing, Beijing, China

The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer

Phase 3
Conditions
Gastric Cancer
Interventions
Drug: dexmedetomidine
First Posted Date
2017-04-17
Last Posted Date
2017-04-17
Lead Sponsor
Nanjing PLA General Hospital
Target Recruit Count
50
Registration Number
NCT03117023

A Pilot Study to Evaluate the Impact of Dexmedetomidine on Breast Cancer Recurrence After Surgery

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
Drug: Saline
Drug: Dexmedetomidine
First Posted Date
2017-04-12
Last Posted Date
2022-11-10
Lead Sponsor
RenJi Hospital
Target Recruit Count
148
Registration Number
NCT03109990
Locations
🇨🇳

Renji hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China

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