Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Low Dose Dexmedetomidine and Delirium After Cardiac Surgery

Phase 4

Completed

Conditions: Cardiac Surgical Procedures

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2018-01-03

Last Posted Date: 2020-09-30

Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Target Recruit Count: 420

Registration Number: NCT03388541

Locations: 🇧🇪
Cliniques Universitaires Saint Luc, Brussels, Belgium

Duration of Analgesia With Dexmedetomidine and Ropivacaine in Brachial Plexus Block

Phase 4

Withdrawn

Conditions: Analgesia
Peripheral Nerve Block
Pain, Acute

Interventions: Drug: ropivacaine
Drug: Dexmedetomidine

First Posted Date: 2017-12-29

Last Posted Date: 2019-05-23

Lead Sponsor: University of Florida

Registration Number: NCT03385967

Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Phase 4

Recruiting

Conditions: Pediatric Anesthesia

Interventions: Drug: Dexmedetomidine

First Posted Date: 2017-12-27

Last Posted Date: 2024-05-23

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 180

Registration Number: NCT03384563

Locations: 🇺🇸
Texas Children's Hospital, Houston, Texas, United States

Dexmedetomidine Wound Infiltration in Cesarean Section

Not Applicable

Recruiting

Conditions: Postoperative Pain

Interventions: Drug: Dexmedetomidine - Ropivacaine
Other: 0,9% saline
Drug: Dexmedetomidine
Drug: Ropivacaine

First Posted Date: 2017-12-26

Last Posted Date: 2024-07-31

Lead Sponsor: Attikon Hospital

Target Recruit Count: 100

Registration Number: NCT03382938

Locations: 🇬🇷
Paraskevi K Matsota, Athens, Other, Greece

The Effects of Dexmedetomidine Dose on Motor Evoked Potentials

Phase 4

Terminated

Conditions: Spinal Fusion

Interventions: Drug: Dexmedetomidine

First Posted Date: 2017-12-20

Last Posted Date: 2020-04-28

Lead Sponsor: Hospital for Special Surgery, New York

Target Recruit Count: 7

Registration Number: NCT03378973

Locations: 🇺🇸
Hospital for Special Surgery, New York, New York, United States

The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Outcomes in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Cytoreductive Surgery; Double Blind Randomized Controlled Trial

Not Applicable

Completed

Conditions: Colon Cancer

Interventions: Drug: Normal saline
Drug: dexmedetomidine

First Posted Date: 2017-12-12

Last Posted Date: 2019-12-04

Lead Sponsor: Yonsei University

Target Recruit Count: 56

Registration Number: NCT03370588

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of