Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Combination With Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Patients

Phase 4

Conditions: Anxiety

Interventions: Drug: Midazolam
Drug: Midazolam and Dexmedetomidine
Drug: Dexmedetomidine

First Posted Date: 2019-10-22

Last Posted Date: 2019-11-05

Lead Sponsor: Second Affiliated Hospital of Wenzhou Medical University

Target Recruit Count: 138

Registration Number: NCT04135014

Locations: 🇨🇳
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

The Mechanism of Dexmedetomidine in Improving Delirium After Cardiac Surgery

Not Applicable

Conditions: Delirium
Cardiac Surgery
Dexmedetomidine

Interventions: Drug: dexmedetomidine

First Posted Date: 2019-10-15

Last Posted Date: 2019-10-15

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 200

Registration Number: NCT04127500

Locations: 🇨🇳
Nanjing First Hospital, Nanjing, Jiangsu, China

Effect of Intravenous Dexmedetomidine on Patient Discomfort in Laparoscopic Cholecystectomy Under Spinal Anesthesia.

Phase 2

Conditions: Shoulder Pain

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2019-10-04

Last Posted Date: 2021-04-02

Lead Sponsor: Theodor Bilharz Research Institute

Target Recruit Count: 40

Registration Number: NCT04115449

Locations: 🇪🇬
Theodor Bilharz research institute, Cairo, Egypt

Intraoperative Dexmedetomidine and Long-term Outcomes in Elderly After Major Surgery

Phase 4

Completed

Conditions: Overall Survival

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2019-10-01

Last Posted Date: 2022-04-20

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 619

Registration Number: NCT04111926

Locations: 🇨🇳
Peking University First Hospital, Beijing, Beijing, China

Dexmedetomidine and HIPEC

Phase 2

Not yet recruiting

Conditions: Inflammation
Cancer

Interventions: Drug: Placebos
Drug: Dexmedetomidine

First Posted Date: 2019-09-27

Last Posted Date: 2022-11-03

Lead Sponsor: University of British Columbia

Target Recruit Count: 20

Registration Number: NCT04106999

Locations: 🇨🇦
UBC/Medicine, Faculty of/Anesthesiology, Pharmacology & Therapeutics, Vancouver, British Columbia, Canada

Opioid Free Anesthesia in ENT Surgery

Not Applicable

Conditions: Functional Endoscopic Sinus Surgery

Interventions: Drug: Remifentanil
Drug: Dexmedetomidine

First Posted Date: 2019-09-26

Last Posted Date: 2022-08-19

Lead Sponsor: University of Thessaly

Target Recruit Count: 200

Registration Number: NCT04105946

Locations: 🇬🇷
Univeristy of Thessaly, Larissa, Thessaly, Greece

The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation

Phase 3

Conditions: Sedation
ICU Patients

Interventions: Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2019-09-20

Last Posted Date: 2020-02-20

Lead Sponsor: Lebanese American University Medical Center

Target Recruit Count: 394

Registration Number: NCT04096768

Locations: 🇱🇧
Lebanese American University Medical Center- Rizk Hospital, Beirut, Lebanon

Can Head Position Improve Surgical Field During Ear Surgery?

Not Applicable

Completed

Conditions: Intra-operative Bleeding

Interventions: Procedure: Head-Up Position
Drug: Dexmedetomidine
Drug: Induction and maintenance of anaesthesia

First Posted Date: 2019-09-19

Last Posted Date: 2020-10-19

Lead Sponsor: Ain Shams University

Target Recruit Count: 225

Registration Number: NCT04095754

Locations: 🇪🇬
Ain Shams University Hospitals, Cairo, Egypt
🇪🇬
Ain Shams University, Cairo, Egypt

Comparison Of Dexmedetomidine and Fentanyl In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy.

Not Applicable

Completed

Conditions: Cholecystectomy
Elective Surgery

Interventions: Drug: Dexmedetomidine
Drug: Fentanyl

First Posted Date: 2019-09-13

Last Posted Date: 2019-09-24

Lead Sponsor: Dow University of Health Sciences

Target Recruit Count: 60

Registration Number: NCT04089592

Locations: 🇵🇰
Civil Hospital Karachi, Karachi, Sindh, Pakistan
🇵🇰
DUHS, Civil hospital Karachi (CHK), Karachi, Sindh, Pakistan

Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children

Phase 3

Recruiting

Conditions: Mechanically Ventilated, Critically Ill Children

Interventions: Drug: Precedex
Drug: Midazolam

First Posted Date: 2019-09-09

Last Posted Date: 2023-12-11

Lead Sponsor: Douglas Fraser

Target Recruit Count: 120

Registration Number: NCT04082767

Locations: 🇨🇦
Children's Hospital - London Health Sciences Centre, London, Ontario, Canada

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