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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Dexmedetomidine Pharmacokinetics-pharmacodynamics in Mechanically Ventilated Children With Single-organ Respiratory Failure

Phase 3
Terminated
Conditions
Respiratory Failure
First Posted Date
2010-02-26
Last Posted Date
2011-10-04
Lead Sponsor
University Hospital, Ghent
Target Recruit Count
1
Registration Number
NCT01076816
Locations
🇧🇪

University Hospital Ghent, Ghent, Belgium

🇧🇪

Cliniques Universitaires Saint-Luc, Brussels, Belgium

Sedation With Dexmedetomidine During Cardiac Catheterization

Phase 2
Terminated
Conditions
Pulmonary Hypertension
Interventions
Drug: Dexmedetomidine
First Posted Date
2010-02-22
Last Posted Date
2019-04-16
Lead Sponsor
Aruna Nathan
Target Recruit Count
4
Registration Number
NCT01072643
Locations
🇺🇸

The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Dexmedetomidine Versus Placebo in Endoscopic Retrograde Cholangiopancreatography (ERCP) Sedation

Phase 4
Completed
Conditions
Pancreatitis
Interventions
Drug: Precedex
Drug: sodium chlorid 0,9%
First Posted Date
2010-02-18
Last Posted Date
2012-07-16
Lead Sponsor
Helsinki University Central Hospital
Target Recruit Count
50
Registration Number
NCT01070680
Locations
🇫🇮

Helsinki University Central Hospital,Meilahti hospital,Endoscopy unit, Helsinki, Uusimaa, Finland

Comparison of Two Doses of Intranasal Dexmedetomidine as Premedication in Children

Phase 3
Completed
Conditions
Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital
Interventions
Drug: Dexmedetomidine
First Posted Date
2010-02-09
Last Posted Date
2017-10-26
Lead Sponsor
The University of Hong Kong
Target Recruit Count
104
Registration Number
NCT01065701
Locations
🇭🇰

QUeen Mary Hospital, Hong Kong, Hong Kong

Dexmedetomidine Versus Propofol in the Medical Intensive Care Unit (MICU)

Phase 4
Terminated
Conditions
Critical Illness
Mechanical Ventilation
Interventions
Drug: Dexmedetomidine
Drug: Propofol
Drug: Fentanyl
Drug: Midazolam
Behavioral: Physical and Occupational Therapy
First Posted Date
2010-02-01
Last Posted Date
2018-07-03
Lead Sponsor
University of Chicago
Target Recruit Count
41
Registration Number
NCT01059929
Locations
🇺🇸

The University of Chicago Medical Center, Chicago, Illinois, United States

Sleep Intervention During Acute Lung Injury

Phase 4
Completed
Conditions
Critical Illness
Sleep
Acute Lung Injury
Acute Respiratory Distress Syndrome
Interventions
Drug: Dexmedetomidine
Drug: Midazolam and Fentanyl
First Posted Date
2010-01-15
Last Posted Date
2021-08-04
Lead Sponsor
University of Arizona
Target Recruit Count
90
Registration Number
NCT01050699
Locations
🇺🇸

Southern Arizona VA Health Care System, Tucson, Arizona, United States

🇺🇸

University Medical Center, Tucson, Arizona, United States

Sedation in Patients at Risk for Upper Airway Collapse

Not Applicable
Completed
Conditions
Obstructive Sleep Apnea
Interventions
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2010-01-08
Last Posted Date
2015-04-27
Lead Sponsor
University of Rochester
Target Recruit Count
15
Registration Number
NCT01045122
Locations
🇺🇸

University of Rochester, Rochester, New York, United States

Dexmedetomidine Sedation With Third Molar Surgery

Phase 4
Terminated
Conditions
Anesthesia
Interventions
Drug: Dexmedetomidine
Drug: Midazolam
Drug: Ketamine
First Posted Date
2009-11-20
Last Posted Date
2013-06-17
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
18
Registration Number
NCT01017237
Locations
🇺🇸

University of North Carolina School of Dentistry, Chapel Hill, North Carolina, United States

Safety of Dexmedetomidine in Severe Traumatic Brain Injury

Phase 2
Withdrawn
Conditions
Traumatic Brain Injury
Interventions
Drug: Propofol
Drug: Precedex
Drug: Fentanyl
First Posted Date
2009-11-04
Last Posted Date
2023-09-13
Lead Sponsor
University of Maryland, Baltimore
Registration Number
NCT01007773
Locations
🇺🇸

University of Maryland Medical Center, Baltimore, Maryland, United States

Dexmedetomidine for Cesarean Delivery

Phase 1
Completed
Conditions
Pregnant Women Undergoing Cesarean Delivery
Interventions
Drug: Placebo
Drug: Dexmedetomidine
First Posted Date
2009-11-01
Last Posted Date
2012-03-26
Lead Sponsor
King Faisal University
Target Recruit Count
68
Registration Number
NCT01005433
Locations
🇸🇦

King Faisal University, Dammam, Eastern, Saudi Arabia

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