Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects

Phase 3

Completed

Conditions: Sedation

Interventions: Drug: Dexmedetomidine
Drug: Midazolam
Drug: Fentanyl
Drug: Morphine

First Posted Date: 2009-04-03

Last Posted Date: 2015-08-14

Lead Sponsor: Hospira, now a wholly owned subsidiary of Pfizer

Target Recruit Count: 175

Registration Number: NCT00875550

Locations: 🇺🇸
Pediatric Critical Care, Los Angeles, California, United States
🇺🇸
Advocate Lutheran General Children's Hospital, Park Ridge, Illinois, United States
🇺🇸
University of Chicago Comer Children's Hospital, Chicago, Illinois, United States

and more 32 locations

Efficacy and Safety of Dexmedetomidine During Non-Invasive Positive Pressure Ventilation

Phase 2

Completed

Conditions: Acute Respiratory Failure

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2009-03-30

Last Posted Date: 2017-12-18

Lead Sponsor: Tufts Medical Center

Target Recruit Count: 36

Registration Number: NCT00871624

Locations: 🇺🇸
Tufts Medical Center, Boston, Massachusetts, United States
🇺🇸
Winchester Hospital, Winchester, Massachusetts, United States

Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children

Phase 3

Completed

Conditions: Pediatrics
Agitation
Anesthesia

Interventions: Drug: Saline
Drug: Dexmedetomidine

First Posted Date: 2009-03-09

Last Posted Date: 2018-11-27

Lead Sponsor: St. Luke's-Roosevelt Hospital Center

Target Recruit Count: 33

Registration Number: NCT00857727

Locations: 🇺🇸
St Luke's-Roosevelt Hospital Center, New York, New York, United States

Sedation and Pain (The Effect of IV Sedation on Pain Perception)

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: midazolam
Drug: dexmedetomidine
Drug: propofol

First Posted Date: 2009-03-02

Last Posted Date: 2014-06-26

Lead Sponsor: University of Alabama at Birmingham

Target Recruit Count: 86

Registration Number: NCT00853333

Locations: 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States

Adjunct Dexmedetomidine (Precedex®) Therapy Impact on Sedative and Analgesic Requirement

Phase 4

Withdrawn

Conditions: Sedation
Analgesia

Interventions: Drug: Dexmedetomidine

First Posted Date: 2009-02-26

Last Posted Date: 2011-10-06

Lead Sponsor: Avera McKennan Hospital & University Health Center

Registration Number: NCT00852046

Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery

Phase 3

Completed

Conditions: Cranitomy Surgery

Interventions: Drug: Propofol
Drug: Precedex

First Posted Date: 2009-02-23

Last Posted Date: 2012-02-10

Lead Sponsor: The Cooper Health System

Target Recruit Count: 15

Registration Number: NCT00848991

Locations: 🇺🇸
Cooper University Hospital, Camden, New Jersey, United States

Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation

Completed

Conditions: Esophageal Cancer
Chest Wall Disorders
Lung Cancer

Interventions: Drug: Dexmedetomidine

First Posted Date: 2009-02-09

Last Posted Date: 2016-10-04

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 25

Registration Number: NCT00839605

Locations: 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States

How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units

Phase 1

Terminated

Conditions: Delirium
Respiratory Failure

Interventions: Drug: GABA agonist
Drug: Dexmedetomidine

First Posted Date: 2009-01-22

Last Posted Date: 2017-06-05

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 6

Registration Number: NCT00826553

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

The Feasibility of Dexmedetomidine for Awake Fiberoptic Nasal Intubation

Phase 2

Conditions: Awake Fiberoptic Nasal Intubation

Interventions: Drug: Normal Saline 0.9%
Drug: propofol 1%
Drug: dexmedetomidine

First Posted Date: 2008-12-31

Last Posted Date: 2009-07-28

Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Target Recruit Count: 60

Registration Number: NCT00815893

Locations: 🇨🇳
Kaohsiung Medical University Chung-Ho Hospital, Kaohsiung, Taiwan

Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion

Phase 4

Completed

Conditions: Lesions of Lumbosacral Intervertebral Disc
Spinal Fusion Acquired
Spinal Diseases
Spinal Stenosis

Interventions: Drug: 0.9% Saline
Drug: Dexmedetomidine

First Posted Date: 2008-12-16

Last Posted Date: 2018-05-25

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 68

Registration Number: NCT00808665

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

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