Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

The Combination Effect of Dexmedetomidine and Morphine in Postoperative Patient-Controlled Analgesia

First Posted Date
2008-12-02
Last Posted Date
2008-12-02
Lead Sponsor
National Taiwan University Hospital
Target Recruit Count
150
Registration Number
NCT00800826

Dexmedetomidine vs. Propofol for Cataract Surgery

First Posted Date
2008-11-06
Last Posted Date
2012-02-10
Lead Sponsor
The Cooper Health System
Target Recruit Count
24
Registration Number
NCT00786370
Locations
🇺🇸

Cooper University Hospital, Camden, New Jersey, United States

Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients

Not Applicable
Terminated
Conditions
Otitis Media
Interventions
Drug: saline
Drug: dexmedetomidine
First Posted Date
2008-10-23
Last Posted Date
2023-04-13
Lead Sponsor
Ochsner Health System
Target Recruit Count
40
Registration Number
NCT00778063
Locations
🇺🇸

Ochsner Clinic Foundation, New Orleans, Louisiana, United States

Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU

Phase 1
Completed
Conditions
Pharmacokinetics
Sedation
Interventions
Drug: Dexmedetomidine
First Posted Date
2008-09-05
Last Posted Date
2009-04-21
Lead Sponsor
Orion Corporation, Orion Pharma
Target Recruit Count
13
Registration Number
NCT00747721
Locations
🇫🇮

Turku University Hospital, Turku, Finland

Dexmedetomidine Versus Midazolam for Facilitating Extubation

Not Applicable
Completed
Conditions
Critical Illness
Interventions
Drug: Midazolam
Drug: Dexmedetomidine
First Posted Date
2008-09-01
Last Posted Date
2016-09-28
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
23
Registration Number
NCT00744380
Locations
🇺🇸

University of Colorado Hospital, Aurora, Colorado, United States

Population Pharmacokinetics of Dexmedetomidine in ICU Patients

Phase 2
Completed
Conditions
Pharmacokinetics
Interventions
Drug: Dexmedetomidine
First Posted Date
2008-07-14
Last Posted Date
2014-01-03
Lead Sponsor
University of Turku
Target Recruit Count
21
Registration Number
NCT00714857
Locations
🇫🇮

Turku University Hospital, Turku, Finland

Effects of Dexmedetomidine on the Intraoperative Electroencephalogram During Endarterectomy Surgery

Completed
Conditions
Endarterectomy, Carotid
Interventions
Drug: Dexmedetomidine
First Posted Date
2008-07-04
Last Posted Date
2017-05-30
Lead Sponsor
University of California, Davis
Target Recruit Count
22
Registration Number
NCT00710437
Locations
🇺🇸

University of California, Davis Medical Center, Sacramento, California, United States

Dexmedetomidine Cardiovascular Safety in Pediatric Burn Patients

Phase 2
Completed
Conditions
Burns
Sedation
Interventions
Drug: Dexmedetomidine
First Posted Date
2008-06-16
Last Posted Date
2017-07-17
Lead Sponsor
Massachusetts General Hospital
Target Recruit Count
8
Registration Number
NCT00697788
Locations
🇺🇸

Shriners Burn Hospital, Boston, Massachusetts, United States

Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine

First Posted Date
2008-05-05
Last Posted Date
2013-08-23
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
44
Registration Number
NCT00671931
Locations
🇺🇸

Cincinati Children Medical Center, Cincinnati, Ohio, United States

Dexmedetomidine vs Fentanyl for BMT

Phase 4
Completed
Conditions
Otitis
Interventions
Drug: Dexmedetomidine
Drug: Saline
Drug: Fentanyl
First Posted Date
2008-04-08
Last Posted Date
2011-04-25
Lead Sponsor
Children's National Research Institute
Target Recruit Count
101
Registration Number
NCT00654329
Locations
🇺🇸

Children's National Medical Center, Washington, District of Columbia, United States

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