Dexmedetomidine
- Generic Name
- Dexmedetomidine
- Brand Names
- Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C13H16N2
- CAS Number
- 113775-47-6
- Unique Ingredient Identifier
- 67VB76HONO
- Background
An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.
- Indication
Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film...
- Associated Conditions
- Agitation, Alcohol Withdrawal Syndrome
- Associated Therapies
- -
The Pharmacology and Hemodynamics of Dexmedetomidine in Children With Congenital Heart Disease
- Conditions
- Interventions
- First Posted Date
- 2007-05-31
- Last Posted Date
- 2015-06-26
- Lead Sponsor
- Children's National Research Institute
- Target Recruit Count
- 41
- Registration Number
- NCT00480740
- Locations
- 🇺🇸
Children's National Medical Center, Washington, District of Columbia, United States
Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
- Conditions
- Interventions
- First Posted Date
- 2007-05-28
- Last Posted Date
- 2010-08-13
- Lead Sponsor
- Orion Corporation, Orion Pharma
- Target Recruit Count
- 500
- Registration Number
- NCT00479661
- Locations
- 🇷🇺
State Institution B.B. Petrovsky Russian Research Centre of Surgery of RAMS, 2, Abrikosovsky per., Moscow, Russian Federation
🇷🇺Medical Academy of Postgraduate Study, 41, ulica Kirochnaya,, St. Petersburg, Russian Federation
🇳🇱Westfries Gasthuis, Department Intensieve Zorgen, Maelsonstraat 3,, Hoorn, Netherlands
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
- First Posted Date
- 2007-05-01
- Last Posted Date
- 2016-12-05
- Target Recruit Count
- 122
- Registration Number
- NCT00468052
- Locations
- 🇺🇸
UMDNJ University Hospital, Newark, New Jersey, United States
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Heart Surgery
- First Posted Date
- 2007-04-24
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
- Registration Number
- NCT00464763
- Locations
- 🇺🇸
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
🇺🇸Baylor University Medical Center, Dallas, Texas, United States
🇺🇸Cardiothoracic and Vascular Surgical Specialists, Columbus, Ohio, United States
Use of Dexmedetomidine to Facilitate Extubation in Surgical ICU Patients Who Failed Previous Weaning Attempts
- Conditions
- Interventions
- First Posted Date
- 2007-04-23
- Last Posted Date
- 2014-10-31
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 42
- Registration Number
- NCT00464490
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Dexmedetomidine Versus Chloral Hydrate for Pediatric Sedation During EEG
- Conditions
- Interventions
- First Posted Date
- 2007-04-23
- Last Posted Date
- 2016-11-03
- Lead Sponsor
- Wesley Medical Center
- Registration Number
- NCT00464451
- Locations
- 🇺🇸
Pediatric Sedation Unit, Wesley Medical Center, Wichita, Kansas, United States
A Research Study to Evaluate the Effectiveness of Dexmedetomidine in Preventing Delirium After Hip Fracture Repair Surgery
- First Posted Date
- 2007-04-16
- Last Posted Date
- 2015-07-24
- Lead Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
- Target Recruit Count
- 52
- Registration Number
- NCT00460473
- Locations
- 🇺🇸
LAC-USC Medical Center Los Angeles, Los Angeles, California, United States
🇺🇸Parkland Health and Hospital System, Dallas, Texas, United States
🇺🇸The Cleveland Clinic Foundation, Cleveland, Ohio, United States
Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
- First Posted Date
- 2007-01-04
- Last Posted Date
- 2022-05-27
- Lead Sponsor
- Stanford University
- Target Recruit Count
- 90
- Registration Number
- NCT00417664
- Locations
- 🇺🇸
Stanford University Medical Center, Stanford, California, United States
Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms
- Conditions
- Interventions
- First Posted Date
- 2006-12-08
- Last Posted Date
- 2009-09-22
- Lead Sponsor
- Massachusetts General Hospital
- Registration Number
- NCT00409344
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
- Conditions
- First Posted Date
- 2006-11-30
- Last Posted Date
- 2016-10-27
- Lead Sponsor
- University of Arizona
- Target Recruit Count
- 17
- Registration Number
- NCT00405847
- Locations
- 🇺🇸
Southern Arizona VA Healthcare System, Tucson, Arizona, United States
Drug Development Updates
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