Diclofenac
- Generic Name
- Diclofenac
- Brand Names
- Aleve Arthritis Pain, Arthrotec, Cambia, Cataflam, Flector, Licart, Lofena, Pennsaid, Previdolrx Analgesic Pak, Salonpas Pain Relieving Patch, Solaraze, Voltaren, Voltaren Emulgel, Xrylix, Zipsor, Zorvolex
- Drug Type
- Small Molecule
- Chemical Formula
- C14H11Cl2NO2
- CAS Number
- 15307-86-5
- Unique Ingredient Identifier
- 144O8QL0L1
- Background
Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID). NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and in...
- Indication
Diclofenac is indicated for use in the treatment of pain and inflammation from varying sources including inflammatory conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, as well as injury-related inflammation due to surgery and physical trauma. It is often used in combination with misoprostol as a gastro-protective agent in p...
- Associated Conditions
- Actinic Keratosis (AK), Acute Arthritis, Acute Gouty Arthritis, Acute Migraine, Acute Musculoskeletal Pain, Ankylosing Spondylitis (AS), Common Cold, Fever, Gout, Inflammation, Inflammatory Disease of the Oral Cavity, Inflammatory Disease of the throat, Inflammatory Reaction of the Nerve, Joint Pain, Juvenile Idiopathic Arthritis (JIA), Menstrual Distress (Dysmenorrhea), Muscle Inflammation, Myalgia, Neuropathic Pain, Ocular Inflammation, Osteoarthritis (OA), Osteoarthritis of the Knee, Pain, Pain caused by Rheumatism, Pericarditis, Photophobia, Postoperative Inflammatory Response, Postoperative pain, Primary Dysmenorrhoea, Radicular Pain, Rheumatism, Rheumatoid Arthritis, Seasonal Allergic Conjunctivitis, Spinal pain, Tendon pain, Vertebral column pain, Acute Musculoskeletal injury, Acute, moderate, severe Pain, Inflammatory, Localized soft tissue rheumatism, Mild to moderate joint pain, Mild to moderate pain, Minor pain, Perioperative miosis
- Associated Therapies
- -
Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention
- Conditions
- Interventions
- First Posted Date
- 2013-07-25
- Last Posted Date
- 2013-07-25
- Lead Sponsor
- University of Debrecen
- Target Recruit Count
- 200
- Registration Number
- NCT01907984
- Locations
- 🇭🇺
University of Debrecen Medical and Health Science Center Department of Anesthesiology and Intensive Care, Debrecen, Hajdú-Bihar, Hungary
Pharmacokinetic Drug Interaction Between YH4808 and Diclofenac
- First Posted Date
- 2013-06-12
- Last Posted Date
- 2014-01-01
- Lead Sponsor
- Yuhan Corporation
- Target Recruit Count
- 49
- Registration Number
- NCT01876615
- Locations
- 🇰🇷
Chungnam National University Hospital, Daejeon, Korea, Republic of
NSAID Treatment in Knee Osteoarthritis
- Conditions
- Interventions
- First Posted Date
- 2013-05-23
- Last Posted Date
- 2013-05-23
- Lead Sponsor
- University of Catanzaro
- Target Recruit Count
- 90
- Registration Number
- NCT01860833
- Locations
- 🇮🇹
Department of Orthopedic and Trauma Surgery, Catanzaro, Italy
Intrathecal Levobupivacaine With Opioids for Caesarean Section
- First Posted Date
- 2013-05-21
- Last Posted Date
- 2013-05-21
- Lead Sponsor
- Baskent University
- Target Recruit Count
- 93
- Registration Number
- NCT01858090
- Locations
- 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey
Diclofenac Suppository to Control Pain During Flexible Cystoscopy
- First Posted Date
- 2013-03-18
- Last Posted Date
- 2013-12-17
- Lead Sponsor
- Aga Khan University
- Target Recruit Count
- 60
- Registration Number
- NCT01812928
- Locations
- 🇵🇰
Aga Khan University Hospital, Karachi, Sindh, Pakistan
Efficacy of Diclofenac on Pain During Endometrial Sampling
- Conditions
- Interventions
- First Posted Date
- 2013-01-07
- Last Posted Date
- 2013-01-07
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 90
- Registration Number
- NCT01762306
- Locations
- 🇹🇭
Faculty of Medicine Siriraj Hospital Mahidol University, Bangkok, Thailand
Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis
- Conditions
- Interventions
- First Posted Date
- 2012-10-30
- Last Posted Date
- 2021-05-04
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 343
- Registration Number
- NCT01717599
- Locations
- 🇰🇷
Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea, Republic of
Injectable Diclofenac for the Prevention of Post-operative Dental Pain
- First Posted Date
- 2012-10-15
- Last Posted Date
- 2014-09-05
- Lead Sponsor
- IBSA Institut Biochimique SA
- Target Recruit Count
- 75
- Registration Number
- NCT01706588
- Locations
- 🇬🇧
The School of Dentistry University of Birmingham, Birmingham, United Kingdom
Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors
- Conditions
- Interventions
- First Posted Date
- 2012-05-11
- Last Posted Date
- 2020-12-21
- Lead Sponsor
- Novartis Pharmaceuticals
- Target Recruit Count
- 39
- Registration Number
- NCT01596647
- Locations
- 🇺🇸
Comprehensive Cancer Centers, Las Vegas, Nevada, United States
🇺🇸University of Kansas Cancer Center Medical Center, Kansas City, Kansas, United States
🇺🇸Henry Ford Hospital Henry Ford, Detroit, Michigan, United States
Diclofenac for Submassive PE
- First Posted Date
- 2012-05-02
- Last Posted Date
- 2017-09-06
- Lead Sponsor
- Ministry of Health, Spain
- Target Recruit Count
- 34
- Registration Number
- NCT01590342
- Locations
- 🇪🇸
Ramon y Cajal Hospital, IRYCIS, Madrid, Spain
Drug Development Updates
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