Bupivacaine
- Generic Name
- Bupivacaine
- Brand Names
- Exparel, Kenalog, Marbeta, Marcaine, Marcaine With Epinephrine, Marvona Suik, P-Care M, P-Care MG, P-care, Posimir, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Sensorcaine, Sensorcaine With Epinephrine, Vivacaine, Xaracoll, Exparel liposomal
- Drug Type
- Small Molecule
- Chemical Formula
- C18H28N2O
- CAS Number
- 38396-39-3
- Unique Ingredient Identifier
- Y8335394RO
- Background
Bupivacaine is a widely used local anesthetic agent.
- Indication
As an implant, bupivacaine is indicated in adults for placement into the surgical site to produce postsurgical analgesia for up to 24 hours following open inguinal hernia repair.
Bupivacaine, in liposome suspension, is indicated in patients aged 6 years and older for single-dose infiltration to produce postsurgical local analgesia. In adults, it is also indicated as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia.
Bupivacaine, in combination with meloxicam, is indicated for postsurgical analgesia in adult patients for up to 72 hours following foot and ankle, small-to-medium open abdominal, and lower extremity total joint arthroplasty surgical procedures.
Bupivacaine, alone or in combination with epinephrine, is indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures. Specific concentrations and presentations are recommended for each type of block indicated to produce local or regional anesthesia or analgesia. Finally, its use is not indicated in all blocks given clinically significant risks associated with use.
- Associated Conditions
- Acute Gouty Arthritis, Adrenocortical Insufficiency, Alopecia Areata (AA), Ankylosing Spondylitis (AS), Berylliosis, Bullous dermatitis herpetiformis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Dermatomyositis (DM), Discoid Lupus Erythematosus (DLE), Edema of the cerebrum, Epicondylitis, Hemolytic Anemia, Hypercalcemia caused by Cancer, Keloids Scars, Leukemias, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Ocular Inflammation, Ophthalmia, Sympathetic, Osteoarthritis (OA), Pain, Labor, Polymyositis, Postoperative pain, Psoriatic Arthritis, Psoriatic plaque, Pure Red Cell Aplasia, Regional Enteritis, Rheumatoid Arthritis, Secondary thrombocytopenia, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Temporal Arteritis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Acute Bursitis, Acute Idiopathic Nephrotic Syndrome, Acute Lupus Erythematosus, Acute Multiple sclerosis, Acute Rheumatic heart disease, unspecified, Acute nonspecific tenosynovitis, Cystic tumors of aponeurosis, Cystic tumors of tendon, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Inflammatory lesions of granuloma annulare, Inflammatory lesions of lichen planus, Inflammatory lesions of lichen simplex, Non-suppurative Thyroiditis, Permphigus, Severe Allergic Reactions
- Associated Therapies
- General Anesthesia, Local Anaesthesia therapy, Regional nerve block therapy
Effect of Bupivacaine-infused Fibrin Sealant Application on Post-tonsillectomy Pain & Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2015-01-21
- Last Posted Date
- 2018-08-10
- Lead Sponsor
- Indiana University School of Medicine
- Target Recruit Count
- 18
- Registration Number
- NCT02343263
- Locations
- 🇺🇸
Riley Childrens' Hospital, Indianapolis, Indiana, United States
Nerveblocks for Persistent Pain After Breast Cancer Surgery
- First Posted Date
- 2015-01-13
- Last Posted Date
- 2015-10-27
- Lead Sponsor
- Kenneth Geving Andersen
- Target Recruit Count
- 48
- Registration Number
- NCT02336529
Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy
- First Posted Date
- 2014-12-31
- Last Posted Date
- 2018-11-30
- Lead Sponsor
- B.P. Koirala Institute of Health Sciences
- Target Recruit Count
- 90
- Registration Number
- NCT02327923
- Locations
- 🇳🇵
BP Koirala Institute of Health Sciences, Dharan, Sunsari District, Nepal
The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI)
- First Posted Date
- 2014-11-17
- Last Posted Date
- 2019-01-11
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 111
- Registration Number
- NCT02292082
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Robotic Hysterectomy
- First Posted Date
- 2014-11-13
- Last Posted Date
- 2023-05-10
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 60
- Registration Number
- NCT02289079
Subcostal TAP Block With Liposomal Bupivacaine Versus Bupivacaine in Donor Nephrectomy Patients: A Prospective Study
- First Posted Date
- 2014-11-11
- Last Posted Date
- 2023-04-10
- Lead Sponsor
- University of Minnesota
- Target Recruit Count
- 60
- Registration Number
- NCT02287623
Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-10-24
- Last Posted Date
- 2018-06-14
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 65
- Registration Number
- NCT02274870
- Locations
- 🇺🇸
Franklin, Valley Stream, New York, United States
Transverse Abdominal Plane Anesthesia for Abdominal Wall Reconstruction
- First Posted Date
- 2014-10-24
- Last Posted Date
- 2016-07-11
- Lead Sponsor
- Chester Mays
- Registration Number
- NCT02274077
- Locations
- 🇺🇸
University of Rochester Medical Center, Rochester, New York, United States
The Transversus Abdominis Plane Block: A Prospective Randomized Clinical Trial Using EXPAREL.
- First Posted Date
- 2014-10-15
- Last Posted Date
- 2023-02-28
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 50
- Registration Number
- NCT02263963
- Locations
- 🇺🇸
Spectrum Health, Grand Rapids, Michigan, United States
Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2014-10-01
- Last Posted Date
- 2017-10-31
- Lead Sponsor
- Hillel Yaffe Medical Center
- Target Recruit Count
- 90
- Registration Number
- NCT02253784
- Locations
- 🇮🇱
Hillel Yaffe Medical Center, Hadera, Israel
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.