Dexamethasone

Generic Name: Dexamethasone

Brand Names: Baycadron, Ciprodex, Decadron, Dexamethasone Intensol, Dextenza, Dioptrol, Hexadrol, Hidex 6-day Taper, Maxidex, Maxitrol, Neofordex, Ozurdex, Taperdex 12 Day Taper, Taperdex 6 Day Taper, Taperdex 7-day Taper, Tobradex, Zcort 7 Day Taper

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₉FO_₅

CAS Number: 50-02-2

Unique Ingredient Identifier: 7S5I7G3JQL

Background: Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like hydrocortisone and prednisolone.

Dexamethasone was granted FDA approval on 30 October 1958. In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.

Indication: Dexamethasone and ciprofloxacin otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa. Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Oral tablets are indicated for the treatment of multiple myeloma. An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye. Various ophthalmic formulations are indicated for inflammatory conditions of the eye.

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Acute Otitis Media (AOM), Adrenocortical Hyperfunction, Adrenocortical Insufficiency, Allergic Conjunctivitis (AC), Alopecia Areata (AA), Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Bursitis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Conjunctivitis, Contact Dermatitis, Cushing's Syndrome, Dermatitis, Diabetic Macular Edema (DME), Discoid Lupus Erythematosus (DLE), Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Episcleritis, Erythroblastopenia, Eye Infections, Eye allergy, Glaucoma, Hypercalcemia, Immune Thrombocytopenia (ITP), Infection, Inflammation, Inflammation of the External Auditory Canal, Intraocular Inflammation, Iridocyclitis, Iritis, Keloids Scars, Keratitis, Lichen Planus (LP), Lichen simplex chronicus, Loeffler's syndrome, Lymphoma, Macular Edema, Meningitis caused by Mycobacterium Tuberculosis, Middle ear inflammation, Mucosal Inflammation of the eye, Multiple Myeloma (MM), Muscle Inflammation caused by Cataract Surgery of the eye, Mycosis Fungoides (MF), Necrobiosis lipoidica diabeticorum, Non-infectious Posterior Uveitis, Ocular Infections, Irritations and Inflammations, Ocular Inflammation, Ocular Inflammation and Pain, Ocular Irritation, Ocular Itching, Ophthalmia, Sympathetic, Optic Neuritis, Otitis Externa, Pemphigus, Perennial Allergic Rhinitis (PAR), Phlyctenular keratoconjunctivitis, Postoperative Infections of the eyes caused by susceptible bacteria, Posttraumatic Osteoarthritis, Regional Enteritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Rosacea, Sarcoidosis, Scleritis, Seasonal Allergic Rhinitis, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Tenosynovitis, Trichinosis, Tuberculosis (TB), Ulcerative Colitis, Uveitis, Vernal Keratoconjunctivitis, Acquired immune hemolytic anemia, Acute rheumatic carditis, Anterior eye segment inflammation, Corticosteroid-responsive dermatoses, Ear infection-not otherwise specified caused by susceptible bacteria, Exfoliative erythroderma, Granuloma annulare lesions, Non-suppurative Thyroiditis, Ocular bacterial infections, Severe Psoriasis, Steroid-responsive inflammation of the eye, Swelling of the eyes, Varicella-zoster virus acute retinal necrosis, Watery itchy eyes

Associated Therapies: -

Clinical Trials

Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial

Phase 1

Recruiting

Conditions: Recurrent Plasma Cell Myeloma
Refractory Plasma Cell Myeloma

Interventions: Drug: Bortezomib
Drug: Dexamethasone
Biological: Pelareorep
Biological: Pembrolizumab

First Posted Date: 2022-08-25

Last Posted Date: 2023-11-18

Lead Sponsor: University of Southern California

Target Recruit Count: 42

Registration Number: NCT05514990

Locations: 🇺🇸
USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States
🇺🇸
Los Angeles County-USC Medical Center, Los Angeles, California, United States

Phase II Study of Carfilzomib, Pomalidomide, and Dexamethasone for Myeloma Patients Who Had Relapsed or Progressed After Carfilzomib, Lenalidomide, and Dexamethasone

Phase 2

Conditions: Multiple Myeloma

Interventions: Drug: Carfilzomib 56 MG [Kyprolis]
Drug: Pomalidomide
Drug: Dexamethasone

First Posted Date: 2022-08-22

Last Posted Date: 2022-08-22

Lead Sponsor: Samsung Medical Center

Target Recruit Count: 33

Registration Number: NCT05509374

Locations: 🇰🇷
Samsung Medical Center, Seoul, Korea, Republic of

Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial

Phase 2

Recruiting

Conditions: ISS Stage III Plasma Cell Myeloma
Multiple Myeloma

Interventions: Procedure: Bone Marrow Aspiration and Biopsy
Drug: Carfilzomib
Procedure: Computed Tomography
Biological: Daratumumab
Drug: Dexamethasone
Drug: Lenalidomide
Procedure: Magnetic Resonance Imaging
Procedure: Positron Emission Tomography
Procedure: Multigated Acquisition Scan

First Posted Date: 2022-08-11

Last Posted Date: 2024-06-21

Lead Sponsor: Mayo Clinic

Target Recruit Count: 75

Registration Number: NCT05497804

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸
Mayo Clinic, Jacksonville, Florida, United States
🇺🇸
Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Local Injection of Steroid VS.Glucose 5% in Carpal Tunnel Syndrome

Phase 4

Conditions: Carpal Tunnel Syndrome

Interventions: Drug: Dexamethasone
Drug: Glucose Injection

First Posted Date: 2022-08-11

Last Posted Date: 2022-08-11

Lead Sponsor: Assiut University

Target Recruit Count: 52

Registration Number: NCT05496764

Locations: 🇪🇬
Assiut University Hospital, Assiut, Egypt

Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Phase 2

Recruiting

Conditions: Diffuse Large B-cell Lymphoma

Interventions: Drug: Polatuzumab vedotin (PV)
Drug: Rituximab
Drug: Hyaluronidase
Drug: Gemcitabine
Drug: Cisplatin
Drug: Dexamethasone
Drug: GCSF

First Posted Date: 2022-08-11

Last Posted Date: 2024-03-05

Lead Sponsor: UNC Lineberger Comprehensive Cancer Center

Target Recruit Count: 44

Registration Number: NCT05498220

Locations: 🇺🇸
Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States

Long-term KRd in Relapsed and/or Refractory Multiple Myeloma

Conditions: Multiple Myeloma in Relapse
Multiple Myeloma, Refractory

Interventions: Drug: Carfilzomib
Drug: Lenalidomide
Drug: Dexamethasone

First Posted Date: 2022-08-10

Last Posted Date: 2022-08-10

Lead Sponsor: Dong-A University Hospital

Target Recruit Count: 300

Registration Number: NCT05495620

Pembrolizumab, Belantamab and Dexamethasone in Refractory Multiple Myeloma.

Phase 1

Withdrawn

Conditions: Multiple Myeloma, Refractory

Interventions: Drug: Pembrolizumab
Drug: Belantamab mafodotin
Drug: Dexamethasone

First Posted Date: 2022-08-09

Last Posted Date: 2023-01-27

Lead Sponsor: Hackensack Meridian Health

Registration Number: NCT05493618

Locations: 🇺🇸
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, United States
🇺🇸
Jersey Shore Medical Center, Neptune, New Jersey, United States
🇺🇸
John Theurer Cancer Center, Hackensack Meridian Health, Hackensack, New Jersey, United States