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Children's Oncology Group

🇺🇸United States

Country: 🇺🇸United States

Ownership: -

Employees: -

Market Cap: -

Website

Clinical Trials

Low-Dose Cytarabine in Treating Infants With Down Syndrome and Transient Myeloproliferative Disorder

Phase 3

Withdrawn

Conditions: Leukemia

Interventions: Procedure: observation
Drug: cytarabine

First Posted Date: 2006-12-13

Last Posted Date: 2015-09-30

Lead Sponsor: Children's Oncology Group

Registration Number: NCT00411281

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Phase 3

Active, not recruiting

Conditions: Anaplastic Medulloblastoma
Medulloblastoma

Interventions: Procedure: Biospecimen Collection
Drug: Carboplatin
Drug: Cisplatin
Drug: Cyclophosphamide
Procedure: Lumbar Puncture
Biological: Filgrastim
Drug: Isotretinoin
Procedure: Magnetic Resonance Imaging
Other: Quality-of-Life Assessment
Radiation: Radiation Therapy
Drug: Vincristine Sulfate

First Posted Date: 2006-10-26

Last Posted Date: 2025-06-13

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 379

Registration Number: NCT00392327

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
🇺🇸
Providence Alaska Medical Center, Anchorage, Alaska, United States

and more 182 locations

Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission

Phase 3

Completed

Conditions: L2 Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia in Remission
L1 Childhood Acute Lymphoblastic Leukemia
Graft Versus Host Disease
T-cell Childhood Acute Lymphoblastic Leukemia
B-cell Childhood Acute Lymphoblastic Leukemia

Interventions: Drug: thiotepa
Drug: cyclophosphamide
Drug: tacrolimus
Drug: methotrexate
Drug: sirolimus
Radiation: total body irradiation

First Posted Date: 2006-09-28

Last Posted Date: 2019-08-07

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 146

Registration Number: NCT00382109

Locations: 🇺🇸
Phoenix Childrens Hospital, Phoenix, Arizona, United States
🇺🇸
City of Hope Medical Center, Duarte, California, United States
🇺🇸
Children's Hospital and Research Center at Oakland, Oakland, California, United States

and more 47 locations

Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: L1 Childhood Acute Lymphoblastic Leukemia
L2 Childhood Acute Lymphoblastic Leukemia
B-cell Childhood Acute Lymphoblastic Leukemia
Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia

Interventions: Drug: vincristine sulfate
Drug: prednisone
Drug: doxorubicin hydrochloride
Drug: pegaspargase
Drug: cytarabine
Drug: methotrexate
Drug: dexamethasone
Drug: etoposide
Drug: cyclophosphamide
Drug: leucovorin calcium
Biological: filgrastim
Drug: asparaginase
Drug: mercaptopurine

First Posted Date: 2006-09-28

Last Posted Date: 2024-03-26

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 275

Registration Number: NCT00381680

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
🇺🇸
Phoenix Childrens Hospital, Phoenix, Arizona, United States

and more 170 locations

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor

Phase 3

Active, not recruiting

Conditions: Stage III Kidney Wilms Tumor
Stage IV Kidney Wilms Tumor

Interventions: Radiation: 3-Dimensional Conformal Radiation Therapy
Procedure: Conventional Surgery
Drug: Cyclophosphamide
Biological: Dactinomycin
Drug: Doxorubicin Hydrochloride
Drug: Etoposide
Drug: Vincristine Sulfate Liposome

First Posted Date: 2006-09-21

Last Posted Date: 2025-05-07

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 395

Registration Number: NCT00379340

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
🇺🇸
USA Health Strada Patient Care Center, Mobile, Alabama, United States

and more 224 locations

Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia

Phase 3

Completed

Conditions: Leukemia

Interventions: Drug: asparaginase
Drug: cytarabine
Drug: daunorubicin hydrochloride
Drug: etoposide
Drug: gemtuzumab ozogamicin
Drug: mitoxantrone hydrochloride

First Posted Date: 2006-09-07

Last Posted Date: 2021-03-24

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 1070

Registration Number: NCT00372593

Locations: 🇺🇸
UAB Comprehensive Cancer Center, Birmingham, Alabama, United States
🇺🇸
University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, United States
🇺🇸
Banner Desert Medical Center, Mesa, Arizona, United States

and more 195 locations

Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia

Phase 1

Completed

Conditions: Leukemia

Interventions: Drug: clofarabine
Drug: cytarabine
Drug: methotrexate
Other: laboratory biomarker analysis

First Posted Date: 2006-09-07

Last Posted Date: 2017-06-05

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 74

Registration Number: NCT00372619

Locations: 🇺🇸
UAB Comprehensive Cancer Center, Birmingham, Alabama, United States
🇺🇸
Southern California Permanente Medical Group, Downey, California, United States
🇺🇸
Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach, California, United States

and more 76 locations

Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes

Phase 3

Completed

Conditions: Childhood Acute Erythroleukemia (M6)
Childhood Acute Megakaryocytic Leukemia (M7)
Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)
Childhood Acute Basophilic Leukemia
Childhood Acute Myeloblastic Leukemia With Maturation (M2)
Childhood Acute Eosinophilic Leukemia
Childhood Acute Monocytic Leukemia (M5b)
Childhood Acute Myelomonocytic Leukemia (M4)
Childhood Myelodysplastic Syndromes
de Novo Myelodysplastic Syndromes

Interventions: Drug: asparaginase
Drug: daunorubicin hydrochloride
Drug: cytarabine
Drug: thioguanine
Drug: etoposide
Other: laboratory biomarker analysis

First Posted Date: 2006-08-29

Last Posted Date: 2022-01-28

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 205

Registration Number: NCT00369317

Locations: 🇺🇸
Phoenix Childrens Hospital, Phoenix, Arizona, United States
🇺🇸
Southern California Permanente Medical Group, Downey, California, United States
🇺🇸
Miller Children's Hospital, Long Beach, California, United States

and more 94 locations

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Phase 3

Completed

Conditions: Adult Rhabdomyosarcoma
Childhood Botryoid-Type Embryonal Rhabdomyosarcoma
Rhabdomyosarcoma
Sarcoma
Stage I Adult Soft Tissue Sarcoma AJCC v7
Stage III Adult Soft Tissue Sarcoma AJCC v7
Localized Childhood Soft Tissue Sarcoma
Childhood Alveolar Rhabdomyosarcoma
Childhood Embryonal Rhabdomyosarcoma
Stage II Adult Soft Tissue Sarcoma AJCC v7

Interventions: Drug: Cyclophosphamide
Biological: Dactinomycin
Other: Laboratory Biomarker Analysis
Drug: Irinotecan Hydrochloride
Other: Questionnaire Administration
Radiation: Radiation Therapy
Drug: Vincristine Sulfate

First Posted Date: 2006-07-20

Last Posted Date: 2023-01-31

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 481

Registration Number: NCT00354835

Locations: 🇺🇸
Children's Hospital of Alabama, Birmingham, Alabama, United States
🇺🇸
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States
🇺🇸
Phoenix Childrens Hospital, Phoenix, Arizona, United States

and more 223 locations

High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

Phase 3

Completed

Conditions: Sarcoma

Interventions: Biological: dactinomycin
Drug: cyclophosphamide
Drug: doxorubicin hydrochloride
Drug: etoposide
Drug: ifosfamide
Drug: irinotecan hydrochloride
Drug: vincristine sulfate
Procedure: conventional surgery
Radiation: radiation therapy
Biological: filgrastim

First Posted Date: 2006-07-20

Last Posted Date: 2020-01-29

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 109

Registration Number: NCT00354744

Locations: 🇺🇸
Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham, Birmingham, Alabama, United States
🇺🇸
Phoenix Children's Hospital, Phoenix, Arizona, United States
🇺🇸
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States

and more 162 locations

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