Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
-

Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries

First Posted Date
2014-12-10
Last Posted Date
2018-05-04
Lead Sponsor
John Fowler
Target Recruit Count
44
Registration Number
NCT02313675
Locations
🇺🇸

Kaufmann Building, Pittsburgh, Pennsylvania, United States

Pharmacokinetics of Intranasal Ketorolac in Children

First Posted Date
2014-11-21
Last Posted Date
2019-01-17
Lead Sponsor
Columbia University
Target Recruit Count
18
Registration Number
NCT02297906
Locations
🇺🇸

New York Presbyterian Morgan Stanley Children's Hospital, New York, New York, United States

Ketorolac Versus Triamcinolone Knee Injections for Osteoarthritis

First Posted Date
2014-11-20
Last Posted Date
2014-11-20
Lead Sponsor
San Antonio Military Medical Center
Target Recruit Count
36
Registration Number
NCT02295189

Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders

First Posted Date
2014-10-17
Last Posted Date
2020-11-02
Lead Sponsor
NYU Langone Health
Target Recruit Count
245
Registration Number
NCT02266433
Locations
🇺🇸

New York University School of Medicine, New York, New York, United States

Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular

First Posted Date
2014-09-16
Last Posted Date
2018-04-19
Lead Sponsor
Mayo Clinic
Target Recruit Count
165
Registration Number
NCT02242201
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair

First Posted Date
2014-05-01
Last Posted Date
2017-01-19
Lead Sponsor
Michael Moncure, MD
Target Recruit Count
40
Registration Number
NCT02128646
Locations
🇺🇸

University of Kansas Medical Center, Kansas City, Kansas, United States

Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery

First Posted Date
2014-04-14
Last Posted Date
2024-10-24
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
78
Registration Number
NCT02112448
Locations
🇺🇸

Advocate Children's Hospital, Oak Lawn, Illinois, United States

Anti-inflammatory Efficacy for Prophylaxis of Cystoid Macular Edema (CME) After Phacoemulsification

First Posted Date
2014-03-12
Last Posted Date
2014-03-12
Lead Sponsor
Hospital Oftalmologico de Brasilia
Target Recruit Count
40
Registration Number
NCT02084576
Locations
🇧🇷

Hospital Oftalmologico de Brasília, Brasilia, DF, Brazil

The Effect of Prophylactic Ketorolac on Sore Throat After Thyroid Surgery

First Posted Date
2014-01-17
Last Posted Date
2017-08-28
Lead Sponsor
Yeungnam University College of Medicine
Target Recruit Count
192
Registration Number
NCT02039427
Locations
🇰🇷

Yeungnam University Hospital, Daegu, Korea, Republic of

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