Ondansetron

Generic Name
Ondansetron
Brand Names
Zofran, Zuplenz
Drug Type
Small Molecule
Chemical Formula
C18H19N3O
CAS Number
99614-02-5
Unique Ingredient Identifier
4AF302ESOS
Background

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
...

Indication

In the adult patient population:

i) orally administered ondansetron tablets and orally disintegrating tablets (ODT) are indicated for:

- the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, including high dose (ie. greater than or equal to 50 mg/m2) cisplatin therapy, and radiotherapy, and
...

Associated Conditions
Chemotherapy-Induced Nausea and Vomiting, Cholestatic pruritus, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Uremic Pruritus, Severe Hyperemesis gravidarum
Associated Therapies
-

The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

First Posted Date
2016-01-15
Last Posted Date
2017-12-11
Lead Sponsor
University Medical Center of Southern Nevada
Target Recruit Count
54
Registration Number
NCT02657031
Locations
🇺🇸

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

Antiemetic Efficacy of Ondansetron Versus Metoclopramide

First Posted Date
2015-12-02
Last Posted Date
2015-12-02
Lead Sponsor
Hospital General Naval de Alta Especialidad - Escuela Medico Naval
Target Recruit Count
250
Registration Number
NCT02619201

EMS Use of Isopropyl Alcohol Aromatherapy Versus Ondansetron

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2015-12-01
Last Posted Date
2021-03-24
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Target Recruit Count
51
Registration Number
NCT02618343
Locations
🇺🇸

San Antonio Fire Department EMS Division, San Antonio, Texas, United States

Evaluation of TAK-058 and Ondansetron on P50 Auditory Gating in Participants With Stable Schizophrenia

First Posted Date
2015-11-25
Last Posted Date
2017-05-01
Lead Sponsor
Takeda
Target Recruit Count
11
Registration Number
NCT02614586

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

First Posted Date
2015-11-10
Last Posted Date
2021-09-23
Lead Sponsor
Stanford University
Target Recruit Count
120
Registration Number
NCT02601027
Locations
🇺🇸

Stanford University Medical Center, Stanford, California, United States

Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting (PONV) in Women Over 60 Years Undergoing Laparoscopic Cholecystectomy

First Posted Date
2015-09-04
Last Posted Date
2017-08-09
Lead Sponsor
Hospital Federal de Bonsucesso
Target Recruit Count
80
Registration Number
NCT02541019
Locations
🇧🇷

Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil

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