Doxycycline

Generic Name: Doxycycline

Brand Names: Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₄N_₂O_₈

CAS Number: 564-25-0

Unique Ingredient Identifier: 334895S862

Background: Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.

Indication: Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

It is also used to treat infections caused by the following gram-negative microorganisms:

Associated Conditions: Acinetobacter Infections, Anthrax, Bacterial Infection caused by Enterobacter aerogenes, Bartonellosis, Brucellosis, Campylobacter Infection, Chancroid, Chlamydia Trachomatis Infection, Early Lyme Disease, Granuloma Inguinale, Infection Due to Escherichia Coli, Inhalational Anthrax, Klebsiella Infections, Lymphogranuloma Venereum, Malaria caused by Plasmodium falciparum, Nongonococcal urethritis, Plague caused by Yersinia pestis, Psittacosis, Rectal infection caused by Chlamydia Trachomatis, Relapsing fever caused by Borrelia recurrentis, Respiratory Tract Infection Bacterial, Rickettsial infectious disorders, Severe Acne, Sexually Transmitted Infections (STIs), Shigella Infection, Trachoma inclusion conjunctivitis, Tularemia, Vibrio Cholerae Infection, Acute Intestinal amebiasis, Susceptible Bacterial Infections, Uncomplicated endocervical infection, Uncomplicated urethral infection

Clinical Trials

Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men

Phase 2

Not yet recruiting

Conditions: Sexually Transmitted Diseases

Interventions: Drug: Doxycyclin
Drug: Pentoxifylline
Drug: Nitazoxanide 500Mg Oral Tablet

First Posted Date: 2023-06-09

Last Posted Date: 2023-06-12

Lead Sponsor: Tanta University

Target Recruit Count: 100

Registration Number: NCT05897034

Doxycycline for Helicobacter Pylori Rescue Treatment

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Esomeprazole
Drug: Bismuth Potassium Citrate
Drug: Tetracycline
Drug: Doxycycline
Drug: Metronidazole

First Posted Date: 2023-05-25

Last Posted Date: 2024-12-30

Lead Sponsor: Shanghai Jiao Tong University School of Medicine

Target Recruit Count: 368

Registration Number: NCT05874570

Locations: 🇨🇳
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China

Efficacy of Ozone Gel, Doxycycline Saturated Chitosan Dressing Versus Alveogyl

Not Applicable

Completed

Conditions: Osteitis
Dry Socket

Interventions: Drug: Ozone gel
Drug: doxycycline hyclate saturated chitosan dressing

First Posted Date: 2023-05-25

Last Posted Date: 2025-01-06

Lead Sponsor: Minia University

Target Recruit Count: 60

Registration Number: NCT05875506

Locations: 🇪🇬
Faculty of Dentistry, Minia University, Minya, Egypt

Doxy-Post-exposure Prophylaxis

Phase 4

Completed

Conditions: Sexually Transmitted Diseases

Interventions: Drug: Doxycycline

First Posted Date: 2023-05-10

Last Posted Date: 2025-02-13

Lead Sponsor: Emory University

Target Recruit Count: 45

Registration Number: NCT05853120

Locations: 🇺🇸
Hope Clinic, Atlanta, Georgia, United States

A Study of Doxycycline to Treat Chlamydial Infection

Phase 4

Recruiting

Conditions: Chlamydial Infection

Interventions: Drug: Doxycycline
Other: Placebo

First Posted Date: 2023-05-03

Last Posted Date: 2025-05-16

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 664

Registration Number: NCT05840159

Locations: 🇺🇸
University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham, Alabama, United States
🇺🇸
Grady Memorial Hospital, Atlanta, Georgia, United States
🇺🇸
Emory University Hospital Midtown - Emory Clinic Infectious Diseases, Atlanta, Georgia, United States

and more 4 locations

Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous Leishmaniasis

Phase 3

Recruiting

Conditions: Leishmaniasis, Cutaneous

Interventions: Drug: Oral doxycycline
Drug: Intralesional Voriconazole
Drug: Intralesional Sodium stibogluconate
Procedure: Intralesional Cryotherapy

First Posted Date: 2023-02-01

Last Posted Date: 2023-08-29

Lead Sponsor: Zagazig University

Target Recruit Count: 136

Registration Number: NCT05708625

Locations: 🇱🇾
Dermatology department, Gharyan University Hospitals, Medical College, Gharyan University, Gharyan, Select Region, Libyan Arab Jamahiriya

Comparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control Trial

Not Applicable

Completed

Conditions: Umbilical Granuloma

Interventions: Other: COMMON SALT
Drug: Doxycyclin

First Posted Date: 2022-09-19

Last Posted Date: 2022-09-19

Lead Sponsor: Shaheed Zulfiqar Ali Bhutto Medical University

Target Recruit Count: 196

Registration Number: NCT05545462

Locations: 🇵🇰
Pakistan institute of medical Sciences/ Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

Doxycycline in Cutaneous Schwannoma (NF2)

Phase 1

Recruiting

Conditions: Neurofibromatosis Type 2

Interventions: Drug: Doxycycline Injection [Doxy]

First Posted Date: 2022-08-30

Last Posted Date: 2025-05-06

Lead Sponsor: Massachusetts Eye and Ear Infirmary

Target Recruit Count: 19

Registration Number: NCT05521048

Locations: 🇺🇸
Massachusetts Eye and Ear, Boston, Massachusetts, United States

Effect of Doxycycline in Levodopa Treated Parkinson's Disease Patients

Phase 2

Conditions: Parkinson Disease

Interventions: Drug: Placebo
Drug: Doxycycline

First Posted Date: 2022-08-08

Last Posted Date: 2022-08-08

Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Target Recruit Count: 60

Registration Number: NCT05492019

Locations: 🇧🇩
Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

Doxycycline Host-directed Therapy to Improve Lung Function and Decrease Tissue Destruction in Pulmonary Tuberculosis

Phase 3

Recruiting

Conditions: Tuberculosis

Interventions: Drug: Placebo
Drug: Doxycycline

First Posted Date: 2022-07-26

Last Posted Date: 2024-12-03

Lead Sponsor: National University Hospital, Singapore

Target Recruit Count: 150

Registration Number: NCT05473520

Locations: 🇲🇾
Hospital Queen Elizabeth I, Kota Kinabalu, Sabah, Malaysia
🇲🇾
Universiti Malaysia Sabah (UMS), Borneo Medical and Health Research Centre, Kota Kinabalu, Sabah, Malaysia
🇸🇬
National University Hospital, Singapore, Singapore

and more 1 locations

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