Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
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Drug: propofol
First Posted Date
2020-01-23
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Registration Number
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An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia

Completed
Conditions
Drug Effect
Anesthesia
Propofol
Interventions
Drug: Propofol
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2020-01-22
Last Posted Date
2020-01-22
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Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

First Posted Date
2020-01-13
Last Posted Date
2020-01-13
Lead Sponsor
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Registration Number
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Columbia University Irving Medical Center, New York, New York, United States

Comparison Between Two Drugs (Propofol and Nitroglycerin as a Hypotensive Agents During Endoscopic Sinus Surgery

Phase 1
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Conditions
Hypotensive Anesthesia
Interventions
Drug: Propofol
Drug: Nitroglycerin
First Posted Date
2020-01-07
Last Posted Date
2020-02-17
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Ain Shams University
Target Recruit Count
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Interest of Audiovisual Distraction in the Management of Anxiety and Pain During Oocyte Retrieval

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2019-12-30
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36
Registration Number
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Hopital FOCH, Suresnes, Ile-de-France, France

Dexmedetomidine Versus Propofol Sedation in Flexible Bronchoscopy: A Randomized Controlled Trial

First Posted Date
2019-12-26
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2019-12-26
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Rabin Medical Center
Target Recruit Count
100
Registration Number
NCT04211298
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Rabin Medical Center, Petach Tikva, Israel

Comparison of Bolus Dosing of Methohexital and Propofol in Elective Direct Current Cardioversion

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2019-12-05
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2023-11-13
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The Effect of Total Intravenous Anesthesia and Volatile Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Laparoscopic or Robotic Assisted Gastrectomy

Not Applicable
Completed
Conditions
Gastrostomy
Interventions
Drug: propofol
Drug: sevoflurane
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2019-12-03
Last Posted Date
2020-09-22
Lead Sponsor
Yonsei University
Target Recruit Count
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Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of

The Influence of Sedation for Endoscopy on Cognitive Function

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Genetic Differences in Propofol Pharmacodynamics in Children

Phase 4
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Interventions
Drug: Propofol
First Posted Date
2019-11-15
Last Posted Date
2024-04-22
Lead Sponsor
University of British Columbia
Target Recruit Count
360
Registration Number
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Locations
🇨🇦

BC Children's Hospital - Department of Anesthesia, Vancouver, British Columbia, Canada

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