Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Phase 4

Completed

Conditions: Unconsciousness
Anesthesia

Interventions: Drug: Placebo
Drug: Dexmedetomidine
Drug: Propofol
Drug: S-ketamine
Drug: Sevoflurane

First Posted Date: 2015-12-08

Last Posted Date: 2017-03-27

Lead Sponsor: University of Turku

Target Recruit Count: 160

Registration Number: NCT02624401

Locations: 🇫🇮
Turku PET Centre, Turku, Finland

Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

Not Applicable

Completed

Conditions: Anesthesia
Hypotension

Interventions: Drug: Methohexital
Drug: Propofol

First Posted Date: 2015-12-08

Last Posted Date: 2019-03-13

Lead Sponsor: Milton S. Hershey Medical Center

Target Recruit Count: 51

Registration Number: NCT02624050

Locations: 🇺🇸
Penn State Milton S Hershey Medical Ctr, Hershey, Pennsylvania, United States

Haemodynamic Stability of Ketamine/Propofol Admixture "Ketofol" in Patient Undergoing Endoscopic Retrograde Cholangio Pancreatography

Phase 2

Terminated

Conditions: Pancreatitis
Cholangitis

Interventions: Drug: Propofol
Drug: Ketamine / Propofol Admixture

First Posted Date: 2015-12-01

Last Posted Date: 2019-09-23

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT02618668

Locations: 🇪🇬
Assiut university hospital, Assiut, Egypt

Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy

Phase 4

Completed

Conditions: Carotid Stenosis

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2015-11-20

Last Posted Date: 2017-01-11

Lead Sponsor: Chonnam National University Hospital

Target Recruit Count: 69

Registration Number: NCT02609087

Locations: 🇰🇷
Chonnam National University Hospital, Gwangju, Korea, Republic of

Dexmedetomidine Versus Propofol for Prolonged Sedation in Poly Traumatized Mechanically Ventilated Patients

Phase 2

Completed

Conditions: Trauma

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2015-11-17

Last Posted Date: 2016-08-23

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02606409

Locations: 🇪🇬
Assiut university hospitals, Assiut, Assiut governorate, Egypt

Does Optimized General Anesthesia Care Reduce Postoperative Delirium?

Not Applicable

Terminated

Conditions: Hip Fractures
Anesthesia
Delirium

Interventions: Procedure: General anesthesia
Device: cerebral oximeter (Fore-Sight)
Drug: propofol
Device: depth of anesthesia monitor (BIS)
Drug: fentanyl
Procedure: BP management
Drug: sevoflurane

First Posted Date: 2015-11-13

Last Posted Date: 2023-10-17

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 145

Registration Number: NCT02604459

Locations: 🇺🇸
University of Missouri Hospitals, Columbia, Missouri, United States

Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy

Phase 4

Completed

Conditions: Delayed Emergence From Anesthesia

Interventions: Drug: Remifentanyl
Drug: Propofol
Drug: Ketamine

First Posted Date: 2015-11-11

Last Posted Date: 2017-02-06

Lead Sponsor: Cukurova University

Target Recruit Count: 70

Registration Number: NCT02602743

Locations: 🇹🇷
Cukurova University Faculty of Medicine Research Hospital, Adana, Turkey

Effect of Dexmedetomidine on Propofol Requirement During Anesthesia

Phase 4

Completed

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Placebo (normal saline)
Drug: Dexmedetomidine

First Posted Date: 2015-11-06

Last Posted Date: 2017-10-04

Lead Sponsor: Dr Nitin Sethi

Target Recruit Count: 80

Registration Number: NCT02599168

Locations: 🇮🇳
Sir Ganga Ram Hospital, New Delhi, India

Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement in Facial Plastic Surgery

Phase 4

Completed

Conditions: Anesthesia, Intravenous; Surgery, Plastic

Interventions: Drug: normal saline
Drug: lidocaine
Drug: propofol

First Posted Date: 2015-11-05

Last Posted Date: 2019-07-30

Lead Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Target Recruit Count: 40

Registration Number: NCT02597140

Locations: 🇰🇷
Chung-Ang University Hospital, Seoul, Korea, Republic of

Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

Not Applicable

Completed

Conditions: Pain

Interventions: Drug: Remifentanil
Drug: propofol
Device: TCI
Procedure: Tetanic stimulation
Device: Algiscan

First Posted Date: 2015-11-03

Last Posted Date: 2017-04-04

Lead Sponsor: Hôpital Armand Trousseau

Target Recruit Count: 12

Registration Number: NCT02595476

Locations: 🇫🇷
Departement d'anesthesie Hopital Armand Trousseau, Paris, France

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