Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Decision Support for Intraoperative Low Blood Pressure

Not Applicable

Completed

Conditions: Hypotension

Interventions: Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Sodium Chloride 0.9%
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine

First Posted Date: 2016-04-04

Last Posted Date: 2019-05-16

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 22435

Registration Number: NCT02726620

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Completed

Conditions: Intravenous Anesthetic Agent Overdose

Interventions: Drug: Propofol

First Posted Date: 2016-03-21

Last Posted Date: 2018-09-26

Lead Sponsor: Centro Hospitalar do Porto

Target Recruit Count: 60

Registration Number: NCT02713698

Locations: 🇵🇹
Centro Hospitalar do Porto, Porto, Portugal

The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children

Not Applicable

Completed

Conditions: Anesthesia, General

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-03-17

Last Posted Date: 2016-10-12

Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Target Recruit Count: 47

Registration Number: NCT02711280

Locations: 🇨🇳
The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Not Applicable

Completed

Conditions: Neuromuscular Monitoring

Interventions: Drug: MAC 0.75
Drug: MAC 1.0
Drug: MAC 0.5
Drug: Propofol
Drug: Etomidate
Drug: Rocuronium

First Posted Date: 2016-03-17

Last Posted Date: 2016-03-17

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 175

Registration Number: NCT02711917

The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia

Phase 4

Completed

Conditions: Anesthesia
Neuromuscular Blockade

Interventions: Drug: Propofol
Drug: Remifentanil
Drug: Rocuronium

First Posted Date: 2016-03-16

Last Posted Date: 2016-07-12

Lead Sponsor: Ankara University

Target Recruit Count: 84

Registration Number: NCT02709473

Locations: 🇹🇷
Ankara University, Ankara, Turkey
🇹🇷
Harran University, Sanliurfa, Turkey

Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Not Applicable

Conditions: Pituitary Adenoma

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Desflurane

First Posted Date: 2016-03-16

Last Posted Date: 2016-03-16

Lead Sponsor: Istanbul University

Target Recruit Count: 90

Registration Number: NCT02709863

Locations: 🇹🇷
Istanbul University Cerrahpasa Medical Faculty Neurosurgery Department, Istanbul, Turkey

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Phase 4

Conditions: Post-operative Residual Curarization

Interventions: Drug: Sugammadex
Device: Diaphragm Ultrasonography
Drug: Neostigmine
Device: Neurumuscual monitoring
Drug: Atropine
Drug: Rocuronium
Drug: Fentanyl
Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2016-03-04

Last Posted Date: 2016-10-25

Lead Sponsor: University of Florence

Target Recruit Count: 58

Registration Number: NCT02698969

Locations: 🇮🇹
Azienda Ospdaliero Universitaria Careggi, Florence, Italy

Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery

Not Applicable

Conditions: Delirium
Cognitive Decline
Post-operative Quality of Recovery

Interventions: Drug: propofol
Drug: Dexmedetomidine

First Posted Date: 2016-03-04

Last Posted Date: 2016-11-03

Lead Sponsor: University of British Columbia

Target Recruit Count: 70

Registration Number: NCT02699801

Locations: 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada

Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Not Applicable

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: sevoflurane
Drug: propofol

First Posted Date: 2016-03-03

Last Posted Date: 2024-08-20

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 135

Registration Number: NCT02697448

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States

Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients

Phase 4

Terminated

Conditions: Glycogen Synthase Kinase 3

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-02-19

Last Posted Date: 2019-08-15

Lead Sponsor: Moscow Regional Research and Clinical Institute (MONIKI)

Target Recruit Count: 10

Registration Number: NCT02686710

Locations: 🇷🇺
Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy, Moscow, Russian Federation

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