Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Anesthetic Techniques in EP Patients

Phase 4

Terminated

Conditions: Cardiac Disease

Interventions: Drug: Propofol
Drug: Sevoflurane
Drug: Ketamine
Drug: Remifentanil

First Posted Date: 2016-01-27

Last Posted Date: 2020-09-22

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 35

Registration Number: NCT02664922

Locations: 🇺🇸
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States

Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium

Not Applicable

Completed

Conditions: Delirium
Postoperative Complications
Postoperative Cognitive Dysfunction

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2016-01-25

Last Posted Date: 2022-03-04

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1228

Registration Number: NCT02662257

Locations: 🇨🇳
Cancer Hospital of Guangxi Medical University, Nanning, Guangxi, China
🇨🇳
Peking University Cancer Hospital, Beijing, Beijing, China
🇨🇳
Peking University School and Hospital of Stomatology, Beijing, Beijing, China

and more 14 locations

Impact of Anesthesia Maintenance Methods on Long-term Survival

Not Applicable

Completed

Conditions: Aged
Neoplasms
Surgical Procedure, Operative
Anesthesia, Inhalation
Anesthesia, Intravenous
Survival

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-01-21

Last Posted Date: 2022-03-04

Lead Sponsor: Peking University First Hospital

Target Recruit Count: 1228

Registration Number: NCT02660411

Locations: 🇨🇳
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, Beijing, China
🇨🇳
Guizhou Provincial People's Hospital, Guiyang, Guizhou, China
🇨🇳
Hebei Medical University Forth Hospital, Shijiazhuang, Hebei, China

and more 14 locations

Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery

Phase 4

Conditions: Hemodynamic Instability
Delirium

Interventions: Drug: Propofol
Drug: Etomidate
Device: Bispectral Index Monitor
Drug: Induction of anesthesia
Drug: Maintenance of anesthesia
Other: Tracheal Intubation