Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

The Effects of Anaesthesia on Cerebral Oxygenation and Cognitive Function in Carotid Endarterectomy

Not Applicable

Completed

Conditions: Endarterectomy
Postoperative Cognitive Dysfunction

Interventions: Drug: Propofol
Drug: Sevoflurane
Procedure: Elective carotid endarterectomy

First Posted Date: 2016-05-13

Last Posted Date: 2016-09-22

Lead Sponsor: Northern State Medical University

Target Recruit Count: 40

Registration Number: NCT02771418

Locations: 🇷🇺
City hospital # 1 / Northern State Medical University,, Arkhangelsk, Russian Federation

Atropine in Laparoscopic Gynaecological Surgery

Phase 4

Conditions: Gynecology
Laparoscopic Surgery

Interventions: Drug: Placebo
Drug: Atropine
Drug: Sevoflurane
Drug: sugammadex
Drug: Ketorolac
Drug: Morphine PCA
Drug: rocuronium
Drug: propofol

First Posted Date: 2016-05-11

Last Posted Date: 2016-05-11

Lead Sponsor: Clinica Santa Maria

Target Recruit Count: 150

Registration Number: NCT02769325

Locations: 🇨🇱
Clinica Santa Maria, Santiago, Chile

Anesthetic Effect on Immune Cell in Patients With Cancer

Not Applicable

Completed

Conditions: Breast Cancer

Interventions: Drug: propofol
Drug: Sevoflurane

First Posted Date: 2016-05-02

Last Posted Date: 2018-01-25

Lead Sponsor: Konkuk University Medical Center

Target Recruit Count: 47

Registration Number: NCT02758249

Locations: 🇰🇷
Konkuk University Medical Center, Seoul, Korea, Republic of

Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV)

Phase 4

Completed

Conditions: Oxygenation During One Lung Ventilation

Interventions: Drug: Inhaled Epoprostenol and phenylephrine
Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2016-04-22

Last Posted Date: 2019-05-17

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 8

Registration Number: NCT02748265

Locations: 🇨🇦
Toronto General Hospital, 200 Elizabeth St., Toronto, Ontario, Canada

Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy

Not Applicable

Suspended

Conditions: Paediatric Flexible Bronchoscopy

Interventions: Drug: Ketamine
Drug: Propofol
Drug: midazolam and atropine
Drug: Lidocaine

First Posted Date: 2016-04-19

Last Posted Date: 2017-04-28

Lead Sponsor: Rabin Medical Center

Target Recruit Count: 150

Registration Number: NCT02743104

Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis

Phase 3

Completed

Conditions: Malignant Neoplasms of Male Genital Organs

Interventions: Procedure: Caudal Nerve Block (CNB)
Drug: Ropivacaine
Drug: Epinephrine
Drug: Decadron
Drug: Clonidine
Drug: Propofol
Behavioral: Phone Call

First Posted Date: 2016-04-15

Last Posted Date: 2022-01-24

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 52

Registration Number: NCT02740127

Locations: 🇺🇸
University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Propofol for Treatment on Emergence Agitation

Phase 4

Conditions: Child
Anesthesia Morbidity

Interventions: Drug: propofol

First Posted Date: 2016-04-14

Last Posted Date: 2016-04-14

Lead Sponsor: Korea University Anam Hospital

Target Recruit Count: 100

Registration Number: NCT02738814

Locations: 🇰🇷
Korea University Medical Center, Anam hospital, Seoul, Seongbuk-gu, Korea, Republic of

Intravenous Propofol and Fentanyl vs Propofol for Sedation in TRUS Biopsy

Phase 4

Completed

Conditions: Pain

Interventions: Other: Control
Drug: Fentanyl
Drug: propofol

First Posted Date: 2016-04-11

Last Posted Date: 2021-09-01

Lead Sponsor: Mahidol University

Target Recruit Count: 124

Registration Number: NCT02733705

Locations: 🇹🇭
Sirilak Suksompong, Bangkok, Thailand

Volatile Anesthetic Protection Of Renal Transplants 2

Phase 4

Conditions: Delayed Graft Function
Renal Outcome After Kidney Transplantation

Interventions: Drug: propofol
Drug: sevoflurane

First Posted Date: 2016-04-04

Last Posted Date: 2020-05-08

Lead Sponsor: Gertrude J. Nieuwenhuijs-Moeke

Target Recruit Count: 488

Registration Number: NCT02727296

Locations: 🇩🇰
Aarhus University Hospital, Aarhus, Denmark
🇪🇸
Fundagio Puigvert, Barcelona, Spain
🇳🇱
University Medical Center Groningen, Groningen, Netherlands

Dexmedetomidine Sedation and Cardiopulmonary Bypass

Phase 2

Completed

Conditions: Coronary Artery Bypass Grafting

Interventions: Drug: propofol
Drug: Dexmedetomidine

First Posted Date: 2016-04-04

Last Posted Date: 2016-09-27

Lead Sponsor: Assiut University

Target Recruit Count: 100

Registration Number: NCT02727621

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

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