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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Effect of Propofol on Cardioprotective Role of Remote Ischemic Preconditioning (RIPC)

Not Applicable
Completed
Conditions
Myocardial Infarction
Interventions
Other: Control
Drug: Propofol
Drug: Sevoflurane
First Posted Date
2016-10-13
Last Posted Date
2018-02-20
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
51
Registration Number
NCT02932722
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

Comparison of Desflurane Anesthesia Versus TIVA-TCI in Patients Undergoing Ophthalmic Ambulatory Surgery

Not Applicable
Completed
Conditions
Anesthesia
Ophthalmic
Surgery
Interventions
Procedure: total intravenous anesthesia
Drug: desflurane
Drug: Propofol
Procedure: inhalation anesthesia
Drug: Remifentanil
First Posted Date
2016-10-04
Last Posted Date
2018-01-23
Lead Sponsor
Xiaoliang Gan
Target Recruit Count
209
Registration Number
NCT02922660
Locations
🇨🇳

Zhongshan ophthalmic center, Sun Yat-sen University, Guangzhou, Guangdong, China

Anesthetics to Prevent Lung Injury in Cardiac Surgery

Phase 1
Completed
Conditions
Inflammatory Lung Injury
Ischemia-Reperfusion Lung Injury
Postoperative Pulmonary Complications
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2016-09-29
Last Posted Date
2021-05-05
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
51
Registration Number
NCT02918877
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Effect of Different Anesthetics on the Change of Alarmins in Lung Cancer Patients Receiving Pulmonary Lobectomy

Not Applicable
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
Drug: Sevoflurane
Drug: Propofol
First Posted Date
2016-09-27
Last Posted Date
2016-09-27
Lead Sponsor
Tianjin Medical University Cancer Institute and Hospital
Target Recruit Count
40
Registration Number
NCT02916147

Etomidate to Improve Outcome in Elderly Patients

Not Applicable
Completed
Conditions
Postoperative Complications
Interventions
Drug: Etomidate
Drug: propofol
Drug: Sufentanil
Drug: Cisatracurium
First Posted Date
2016-09-21
Last Posted Date
2020-12-10
Lead Sponsor
Zhihong LU
Target Recruit Count
1917
Registration Number
NCT02910206
Locations
🇨🇳

Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China

Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU

Phase 4
Terminated
Conditions
Deep Sedation
Ventilators, Mechanical
Critical Illness
Interventions
Drug: Midazolam
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2016-09-16
Last Posted Date
2020-07-13
Lead Sponsor
Duke University
Target Recruit Count
7
Registration Number
NCT02903407
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Comparison Between Dexmedetomidine and Propofol for Patients in the Intensive Care Unit After Abdominal Surgery

Phase 4
Completed
Conditions
Microcirculation
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2016-08-22
Last Posted Date
2019-03-04
Lead Sponsor
National Taiwan University Hospital
Target Recruit Count
60
Registration Number
NCT02874768
Locations
🇨🇳

National Taiwan University Hospital, Taipei, Taiwan

Influence of Gender on Interaction of Propofol and Dexmedetomidine

First Posted Date
2016-08-03
Last Posted Date
2018-01-31
Lead Sponsor
Guangzhou General Hospital of Guangzhou Military Command
Target Recruit Count
120
Registration Number
NCT02853864
Locations
🇨🇳

Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke

First Posted Date
2016-07-04
Last Posted Date
2023-05-23
Lead Sponsor
Rennes University Hospital
Target Recruit Count
351
Registration Number
NCT02822144
Locations
🇫🇷

Fédération d'anesthésie-réanimation - Hôpital Pontchaillou, CHU de Rennes, Rennes, France

🇫🇷

Service d'anesthésie-réanimation - Fondation A. de Rothschild, Paris, France

🇫🇷

Département d'anesthésie-réanimation - Hôpital de la Cavale Blanche, CHU de Brest, Brest, France

and more 1 locations

Comparison of Propofol, Propofol-remifentanil and Propofol-ketamine Anesthesia During Electroconvulsive Therapy

Phase 4
Completed
Conditions
Anesthesia
Electroconvulsive Therapy
Interventions
Drug: Propofol+Remifentanil
Drug: Propofol+Ketamine
Drug: Propofol
First Posted Date
2016-06-30
Last Posted Date
2019-02-27
Lead Sponsor
Inonu University
Target Recruit Count
45
Registration Number
NCT02819375
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