Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Sedation by Dexmedetomidine and Propofol

Not Applicable

Completed

Conditions: Anesthesia, Spinal

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2016-12-15

Last Posted Date: 2017-09-14

Lead Sponsor: Seoul National University Bundang Hospital

Target Recruit Count: 52

Registration Number: NCT02993718

Locations: 🇰🇷
Seoul National University Bundang Hospital, Seongnam, Gyeonggi, Korea, Republic of

Conscious Sedation for Epilepsy Surgery

Not Applicable

Completed

Conditions: Epilepsy

Interventions: Drug: Remifentanil
Drug: Dexmedetomidine
Drug: Propofol
Drug: Bupivacaine
Drug: Lidocaine
Drug: Epinephrine

First Posted Date: 2016-12-09

Last Posted Date: 2020-10-09

Lead Sponsor: Menoufia University

Target Recruit Count: 60

Registration Number: NCT02988050

Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery

Phase 4

Completed

Conditions: Postoperative Cognitive Function

Interventions: Drug: Desflurane
Drug: Propofol

First Posted Date: 2016-12-08

Last Posted Date: 2016-12-08

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 100

Registration Number: NCT02987218

Locations: 🇮🇳
Postgraduate institute of medical education and research, Chandigarh, India

Anesthesia Depth's Influence on Postoperative Delirium

Early Phase 1

Conditions: Femur Head Necrosis

Interventions: Drug: Diprivan

First Posted Date: 2016-11-23

Last Posted Date: 2017-12-15

Lead Sponsor: Xiangya Hospital of Central South University

Target Recruit Count: 80

Registration Number: NCT02972762

Locations: 🇨🇳
Xiangya hospital of CSU, Changsha, Hunan, China

Sevoflurane in Subarachnoidal Haemorrhage

Phase 2

Withdrawn

Conditions: Subarachnoid Haemorrhage (SAH)

Interventions: Drug: Sevoflurane
Drug: Propofol
Device: MIRUS™System
Drug: Midazolam

First Posted Date: 2016-10-27

Last Posted Date: 2020-06-02

Lead Sponsor: University of Zurich

Registration Number: NCT02946437

Locations: 🇨🇭
University Hospital Zurich, Zurich, Switzerland

Effect of Sedation on Intra-abdominal Pressure

Phase 4

Conditions: Intra-abdominal Hypertension

Interventions: Procedure: Deepening of sedation
Drug: Propofol

First Posted Date: 2016-10-25

Last Posted Date: 2017-12-08

Lead Sponsor: Tartu University Hospital

Target Recruit Count: 40

Registration Number: NCT02944292

Locations: 🇪🇪
Tartu University Hospital, Tartu, Tartumaa, Estonia

Patient Satisfaction With Propofol for Out Patient Colonoscopy

Phase 4

Completed

Conditions: IBS
Polyps
Colon Cancer

Interventions: Drug: Fentanyl Plus Midazolam
Drug: Propofol

First Posted Date: 2016-10-18

Last Posted Date: 2017-12-26

Lead Sponsor: Mount Carmel Health System

Target Recruit Count: 600

Registration Number: NCT02937506

Locations: 🇺🇸
Mount Carmel Health System, Columbus, Ohio, United States

Burst Suppression Anesthesia for Treatment of Severe Depression

Phase 1

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Diprivan

First Posted Date: 2016-10-17

Last Posted Date: 2021-06-02

Lead Sponsor: University of Utah

Target Recruit Count: 11

Registration Number: NCT02935647

Locations: 🇺🇸
University Neuropsychiatric Institute, Salt Lake City, Utah, United States

Effects of Propofol and Ketofol on Core Body Temperature in MRI

Not Applicable

Completed

Conditions: Children

Interventions: Drug: propofol
Drug: Ketamine propofol mixture

First Posted Date: 2016-10-13

Last Posted Date: 2018-02-19

Lead Sponsor: Istanbul University

Target Recruit Count: 90

Registration Number: NCT02931786

Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia

Phase 4

Completed

Conditions: Postoperative Cognitive Dysfunction

Interventions: Drug: sevoflurane
Drug: propofol

First Posted Date: 2016-10-13

Last Posted Date: 2018-07-10

Lead Sponsor: Xinqiao Hospital of Chongqing

Target Recruit Count: 300

Registration Number: NCT02931877

Locations: 🇨🇳
Xinqiao Hospital, Third Military Medical University, Chongqing, Chongqing, China
🇨🇳
Xinan Hospital, Third Military Medical University, Chongqing, Chongqing, China
🇨🇳
Daping Hospital, Third Military Medical University, Chongqing, Chongqing, China

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