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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

Non-anesthesiologist-administered Propofol During the Flexible Bronchoscopy

Not Applicable
Completed
Conditions
Conscious Sedation Failure During Procedure
Interventions
Device: Transcutaneous CO2 monitor
Drug: Midazolam
Drug: Propofol
Drug: Nalbuphine
Drug: Lidocaine
First Posted Date
2016-06-30
Last Posted Date
2024-12-02
Lead Sponsor
Hospital Universitario Dr. Jose E. Gonzalez
Target Recruit Count
102
Registration Number
NCT02820051
Locations
🇲🇽

UANL University Hospital, Monterrey, Nuevo León, Mexico

Remifentanil and Midazolam on Propofol for Loss of Consciousness in Elderly Patients

Not Applicable
Conditions
Anesthesia
Interventions
Drug: Propofol
Drug: Remifentanil
Drug: Midazolam
First Posted Date
2016-06-29
Last Posted Date
2016-06-29
Lead Sponsor
Gangnam Severance Hospital
Target Recruit Count
120
Registration Number
NCT02818387
Locations
🇰🇷

Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Korea, Republic of

Laparoscopic Surgery and Abdominal Compliance

Phase 4
Conditions
Patients Ongoing Elective Abdominal Laparoscopy
Interventions
Drug: propofol
Drug: NMBA - cisatracurium
Drug: placebo - isotonic saline serum
Drug: sufentanil
Procedure: laparoscopic surgery
First Posted Date
2016-06-28
Last Posted Date
2016-07-18
Lead Sponsor
CHU de Reims
Target Recruit Count
180
Registration Number
NCT02816567
Locations
🇫🇷

Chu Reims, France, Reims, France

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

Phase 4
Completed
Conditions
Palonosetron
Anesthesia
PONV
Interventions
Drug: Palonosetron
Drug: pentothal sodium
Drug: remifentanil
Drug: sevoflurane
Drug: propofol
First Posted Date
2016-06-22
Last Posted Date
2017-07-21
Lead Sponsor
Ajou University School of Medicine
Target Recruit Count
150
Registration Number
NCT02809378
Locations
🇰🇷

Ajou universiry hospital, Suwon, Gyeonggi-do, Korea, Republic of

Influence of Dexmedetomidine or Propofol on ICU Delirium

Phase 4
Terminated
Conditions
Delirium
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2016-06-21
Last Posted Date
2023-06-06
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
37
Registration Number
NCT02807467
Locations
🇨🇭

Intensive Care Units, University Hospital Basel, Basel, Switzerland

Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.

Not Applicable
Completed
Conditions
Local Anesthesia
Anesthesia
Interventions
Drug: propofol
Drug: dexmedetomidine
First Posted Date
2016-06-08
Last Posted Date
2017-06-29
Lead Sponsor
The First Affiliated Hospital of Anhui Medical University
Target Recruit Count
296
Registration Number
NCT02793986
Locations
🇨🇳

The first affiliated hospital of Anhui Medical University, Hefei, Anhui, China

Association of Type of Anesthetic and Outcomes in Transfemoral Aortic Valve Replacement

Completed
Conditions
Aortic Stenosis
Interventions
Drug: Dexmedetomidine with propofol
Drug: Propofol
First Posted Date
2016-05-30
Last Posted Date
2023-04-24
Lead Sponsor
Yale University
Target Recruit Count
186
Registration Number
NCT02786264

Intraoperative Sedatives and Postoperative Pain

Phase 4
Completed
Conditions
Arthritis, Degenerative
Interventions
Drug: Dexmedetomidine
Drug: Propofol
First Posted Date
2016-05-27
Last Posted Date
2016-10-27
Lead Sponsor
Seoul National University Bundang Hospital
Target Recruit Count
48
Registration Number
NCT02784626
Locations
🇰🇷

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of

Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia

First Posted Date
2016-05-19
Last Posted Date
2016-07-28
Lead Sponsor
Guangzhou General Hospital of Guangzhou Military Command
Target Recruit Count
64
Registration Number
NCT02777619
Locations
🇨🇳

Guangzhou Military Region General Hospital, Department of Anesthesiology, Guangzhou, Guangdong, China

Dexmedetomidine Verses Propofol for Paediatric MRI Brain

Phase 4
Completed
Conditions
Brain Diseases
Interventions
Drug: Dexmedetomidine
Drug: propofol
Drug: Midazolam
First Posted Date
2016-05-18
Last Posted Date
2016-07-19
Lead Sponsor
Maharashtra University of Health Sciences
Target Recruit Count
70
Registration Number
NCT02776189
Locations
🇮🇳

Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, Mumbai, Maharastra, India

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