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Propofol

Generic Name
Propofol
Brand Names
Diprivan
Drug Type
Small Molecule
Chemical Formula
C12H18O
CAS Number
2078-54-8
Unique Ingredient Identifier
YI7VU623SF
Background

Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication

Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions
-
Associated Therapies
Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy
Clinical Trials
Related News

The Effective Effect-Site Propofol Concentration for Induction and Intubation for Schnider Model in Parturients

Not Applicable
Conditions
C.Delivery; Surgery (Previous), Gynecological
Interventions
Drug: Propofol
First Posted Date
2015-09-18
Last Posted Date
2015-09-18
Lead Sponsor
Fudan University
Target Recruit Count
36
Registration Number
NCT02554175

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

Phase 2
Completed
Conditions
Delirium
Cognitive Disorders
Acute Kidney Injury
Interventions
Drug: Ketamine
Drug: Propofol
First Posted Date
2015-09-18
Last Posted Date
2022-02-15
Lead Sponsor
Mayo Clinic
Target Recruit Count
52
Registration Number
NCT02554253
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Propofol Versus Dexmedetomidine for Prevention of Sevoflurane Agitation in Recipients of Living Donor Liver Transplantation

Not Applicable
Conditions
Liver Transplantation
Interventions
Drug: dexmedetomedine
Drug: Propofol
First Posted Date
2015-09-09
Last Posted Date
2015-09-09
Lead Sponsor
AlRefaey Kandeel
Target Recruit Count
120
Registration Number
NCT02544906
Locations
🇪🇬

Mansoura university, Mansoura, Dkahleya, Egypt

Pharmacokinetic/Pharmacodynamic Model of Propofol in Children

Phase 4
Conditions
Anesthesia
Interventions
Drug: Propofol
First Posted Date
2015-09-09
Last Posted Date
2016-10-12
Lead Sponsor
Pontificia Universidad Catolica de Chile
Target Recruit Count
40
Registration Number
NCT02544854
Locations
🇨🇱

Division de Anestesia - Pontificia Universidad Catolica de Chile, Santiago, Region Metropolitana, Chile

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Phase 4
Completed
Conditions
Pain, Postoperative
Postoperative Nausea and Vomiting
Interventions
Drug: Levobupivacaine
Drug: NaCl 0.9%
Drug: Sevoflurane
Drug: Propofol
Drug: Sufentanil
Drug: Atracurium
Drug: Paracetamol
Drug: Tramadol
Drug: Piritramide
First Posted Date
2015-09-09
Last Posted Date
2016-07-13
Lead Sponsor
GZA Ziekenhuizen Campus Sint-Augustinus
Target Recruit Count
140
Registration Number
NCT02544282
Locations
🇧🇪

GZA Sint Augustinus, Wilrijk, Antwerpen, Belgium

Remifentanil and Midazolam on Propofol for Loss of Consciousness

Not Applicable
Completed
Conditions
Anesthesia
Interventions
Drug: Propofol
Drug: Remifentanil
Drug: Midazolam
First Posted Date
2015-09-01
Last Posted Date
2016-06-02
Lead Sponsor
Severance Hospital
Target Recruit Count
120
Registration Number
NCT02536690
Locations
🇰🇷

Gangnam Severance hospital, Seoul, Gangnam-gu, Korea, Republic of

Postoperative Quality of Recovery After Transurethral Resection of the Bladder

Not Applicable
Conditions
Urinary Bladder Neoplasms
Transurethral Resection of the Bladder
Postoperative Recovery
Interventions
Procedure: General anesthesia
Procedure: Spinal anesthesia
Drug: fentanyl
Drug: bupivacaine
Drug: propofol
Drug: sevoflurane
First Posted Date
2015-08-27
Last Posted Date
2015-08-27
Lead Sponsor
General Hospital Zadar
Target Recruit Count
70
Registration Number
NCT02534623
Locations
🇭🇷

General Hospital Zadar, Zadar, Croatia

Intra-carotid Anesthetic Agent Delivery

Not Applicable
Conditions
Anesthesia
Interventions
Drug: propofol
First Posted Date
2015-08-24
Last Posted Date
2015-08-24
Lead Sponsor
Mansoura University
Target Recruit Count
5
Registration Number
NCT02531477
Locations
🇪🇬

Mansoura university, Mansoura, Dakahleya, Egypt

The Effects of General Anesthesia on Microcirculation of Central and Peripheral Soft Tissue: a Comparison of Inhalational and Intravenous Anesthetics

Not Applicable
Conditions
Inhalation and Intravenous Anesthesia
Microcirculatory Effects of Anesthesia
Interventions
Drug: Sevoflurane
Drug: Propofol
Procedure: General anesthesia induction
First Posted Date
2015-08-21
Last Posted Date
2016-04-13
Lead Sponsor
National Taiwan University Hospital
Target Recruit Count
100
Registration Number
NCT02530632
Locations
🇨🇳

National Taiwan University Hospital, Taipei City, Taiwan

Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

Phase 4
Conditions
Mechanical Ventilation
Complication
Delirium
Interventions
Drug: midazolam
Drug: Fentanyl
Drug: midazolam(used for passing the SBT safety screen)
Drug: propofol
Drug: Dexmedetomidine
First Posted Date
2015-08-19
Last Posted Date
2016-04-28
Lead Sponsor
West China Hospital
Target Recruit Count
240
Registration Number
NCT02528513
Locations
🇨🇳

Department of Critical care medicine of West China Hospital, Chengdu, Sichuan, China

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