Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

Phase 4

Completed

Conditions: Hernia
Acute Pain
Anesthesia, Intratracheal
Chronic Pain
Anesthesia, Intravenous

Interventions: Drug: Sevoflurane
Drug: Propofol
Drug: Remifentanil
Drug: Ketamine

First Posted Date: 2015-08-18

Last Posted Date: 2020-10-08

Lead Sponsor: VA Pittsburgh Healthcare System

Target Recruit Count: 10

Registration Number: NCT02527083

Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery

Phase 3

Terminated

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Remimazolam

First Posted Date: 2015-08-14

Last Posted Date: 2023-08-30

Lead Sponsor: Paion UK Ltd.

Target Recruit Count: 25

Registration Number: NCT02523859

Locations: 🇩🇪
Herzzentrum Leipzig GmbH, Leipzig, Germany

Comparison of Desflurane and Propofol on Quality of Recovery in Patients Undergoing Robotic or Laparoscopic Gastrectomy

Not Applicable

Withdrawn

Conditions: General Anesthesia

Interventions: Drug: Desflurane
Drug: Propofol

First Posted Date: 2015-08-05

Last Posted Date: 2019-02-15

Lead Sponsor: Yonsei University

Registration Number: NCT02515968

Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation

Not Applicable

Terminated

Conditions: Pain

Interventions: Drug: Normal Saline
Drug: Lidocaine
Drug: Propofol

First Posted Date: 2015-07-31

Last Posted Date: 2016-07-21

Lead Sponsor: Children's Hospitals and Clinics of Minnesota

Target Recruit Count: 171

Registration Number: NCT02512783

Locations: 🇺🇸
Children's Hospitals and Clinics of Minnesota, Saint Paul, Minnesota, United States

Impact of Topical Pharyngeal Anesthetics on Discharge of the Patients When Used in Conjunction With Propofol Sedation in Routine EGD's

Phase 4

Completed

Conditions: Topical Anesthesia

Interventions: Drug: Placebo
Drug: Lidocaine
Drug: Propofol

First Posted Date: 2015-07-24

Last Posted Date: 2017-01-10

Lead Sponsor: Bassett Healthcare

Target Recruit Count: 100

Registration Number: NCT02507440

Locations: 🇺🇸
Bassett Healthcare Network, Cooperstown, New York, United States

The Efficacy and Optimal Dose of Sufentanil in Patient Controlled Analgesia After Moderate Surgery

Phase 4

Conditions: Analgesia, Patient-Controlled
Arthroplasty
Gastrectomy

Interventions: Drug: Sufentanil
Drug: Midazolam
Drug: propofol
Drug: cisatracurium

First Posted Date: 2015-07-21

Last Posted Date: 2015-07-21

Lead Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Target Recruit Count: 60

Registration Number: NCT02503826

Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia

Not Applicable

Completed

Conditions: Anesthesia
Body Temperature Changes

Interventions: Drug: Midazolam
Drug: Propofol
Drug: Standard
Device: SpotOn

First Posted Date: 2015-07-20

Last Posted Date: 2016-04-06

Lead Sponsor: Hospital da Luz, Portugal

Target Recruit Count: 27

Registration Number: NCT02502877

Locations: 🇵🇹
Hospital da Luz, Lisboa, Portugal

Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery

Not Applicable

Completed

Conditions: Ischemic Heart Disease

Interventions: Drug: Remifentanil
Drug: sevoflurane 2
Drug: propofol
Drug: sevoflurane 1
Drug: sufentanil

First Posted Date: 2015-07-16

Last Posted Date: 2015-07-16

Lead Sponsor: Konkuk University Medical Center

Target Recruit Count: 120

Registration Number: NCT02499445

Locations: 🇰🇷
Konkuk University Medical Center, Seoul, Korea, Republic of

Low-dose Propofol for the Treatment of Severe Refractory Migraine Headache in the Emergency Department

Not Applicable

Terminated

Conditions: Migraine Headache

Interventions: Drug: Propofol

First Posted Date: 2015-07-08

Last Posted Date: 2020-03-19

Lead Sponsor: Albert Einstein Healthcare Network

Target Recruit Count: 12

Registration Number: NCT02492295

Locations: 🇺🇸
Albert Einstein Medical Center, Philadelphia, Pennsylvania, United States

Evaluation of a Novel Closed-loop Propofol and Remifentanil System Guided by Bispectral Index Compared to a TCI Open-loop System

Phase 3

Completed

Conditions: Anesthesia, General
Anesthesia, Intravenous

Interventions: Device: Closed-Loop propofol and remifentanil system by Bispectral Index
Device: Open-Loop propofol and remifentanil by Target Controlled Infusion
Drug: propofol

First Posted Date: 2015-07-08

Last Posted Date: 2016-06-20

Lead Sponsor: Universidad de Antioquia

Target Recruit Count: 150

Registration Number: NCT02492282

Locations: 🇨🇴
Hospital Universitario San Vicente Fundación, Medellin, Antioquia, Colombia

Drug Development Updates

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