Propofol

Generic Name: Propofol

Brand Names: Diprivan

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₁₈O

CAS Number: 2078-54-8

Unique Ingredient Identifier: YI7VU623SF

Background: Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.

Indication: Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.

Associated Conditions: -

Associated Therapies: Induction of anesthesia therapy, Maintenance of anesthesia therapy, Monitored anesthesia care sedation, Sedative therapy

Clinical Trials

Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery

Phase 4

Conditions: Arteriovenous Fistula

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2015-05-19

Last Posted Date: 2015-05-19

Lead Sponsor: Baskent University

Target Recruit Count: 48

Registration Number: NCT02447796

Locations: 🇹🇷
Baskent University School of Medicine Adana Research and Teaching Center, Adana, Turkey

Assessment of Cognitive Functions and Quality of Life in Patients Undergoing Surgery for Supratentorial Brain Tumor

Not Applicable

Conditions: Brain Tumor

Interventions: Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2015-04-29

Last Posted Date: 2017-01-24

Lead Sponsor: All India Institute of Medical Sciences, New Delhi

Target Recruit Count: 30

Registration Number: NCT02428972

EEG Studies of IV Methylphenidate-Induced Emergence From Anesthesia

Phase 1

Withdrawn

Conditions: Active Emergence From General Anesthesia

Interventions: Drug: IV methylphenidate
Drug: Placebo
Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2015-04-29

Last Posted Date: 2017-08-02

Lead Sponsor: Massachusetts General Hospital

Registration Number: NCT02429076

Clinical Trial on Individual Characteristics Affecting Pain Drug Therapy in Neonates

Phase 4

Completed

Conditions: Critical Illness

Interventions: Drug: oxycodone
Drug: propofol

First Posted Date: 2015-04-27

Last Posted Date: 2019-02-04

Lead Sponsor: Turku University Hospital

Target Recruit Count: 80

Registration Number: NCT02426463

Locations: 🇫🇮
Department of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland

Inducibility and Stability of Ventricular Tachycardia Inpatients Undergoing VT Ablation Under General Anesthesia

Not Applicable

Completed

Conditions: Ventricular Tachycardia

Interventions: Drug: Versed
Drug: Fentanyl
Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2015-04-17

Last Posted Date: 2019-10-09

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 11

Registration Number: NCT02419547

Locations: 🇺🇸
Brigahm and Women's Hospital, Boston, Massachusetts, United States

Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults

Not Applicable

Completed

Conditions: Joint Dislocation
Perianal Abscess
Abscess

Interventions: Drug: Nitrous Oxide arm
Drug: Propofol
Drug: Oxygen

First Posted Date: 2015-04-08

Last Posted Date: 2020-04-08

Lead Sponsor: Albert Einstein Healthcare Network

Target Recruit Count: 43

Registration Number: NCT02410707

Locations: 🇺🇸
Albert Einstein Medical Center, Philadelphia, Pennsylvania, United States

Anesthetics in Rhytidoplasty - A Comparison Study

Not Applicable

Completed

Conditions: Rhytidoplasty

Interventions: Drug: clonidine
Drug: glycopyrrolate
Drug: propofol
Drug: scopolamine
Drug: ketamine
Drug: midazolam
Device: ondansetron
Drug: marcaine
Drug: lidocaine
Drug: metoclopramide
Drug: famotidine
Drug: desflurane
Drug: sevoflurane

First Posted Date: 2015-04-07

Last Posted Date: 2015-04-07

Lead Sponsor: Mercy Facial Plastic Surgery Center

Target Recruit Count: 30

Registration Number: NCT02410460

Locations: 🇺🇸
Mercy Facial Plastic Surgery Center, Springfield, Missouri, United States

Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery

Not Applicable

Terminated

Conditions: Myocardial Ischemia

Interventions: Drug: Sevoflurane
Drug: Propofol

First Posted Date: 2015-04-03

Last Posted Date: 2018-03-09

Lead Sponsor: Triemli Hospital

Target Recruit Count: 2

Registration Number: NCT02407626

Locations: 🇨🇭
Triemli City Hospital, Zurich, Switzerland

A Study Comparing Remimazolam Tosilate and Propofol for Intravenous General Anaesthesia in Operations

Phase 2

Completed

Conditions: General Anesthesia

Interventions: Drug: Remimazolam Tosilate
Drug: Propofol

First Posted Date: 2015-04-02

Last Posted Date: 2015-12-31

Lead Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Target Recruit Count: 144

Registration Number: NCT02406872

Locations: 🇨🇳
Peking Union Medical College Hospital, Peking, Beijing, China

Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department

Phase 4

Completed

Conditions: Pain

Interventions: Procedure: Moderate Procedural Sedation with a sedative medication.
Procedure: Deep Procedural Sedation with a sedative medication.
Drug: propofol

First Posted Date: 2015-03-31

Last Posted Date: 2021-11-30

Lead Sponsor: Hennepin Healthcare Research Institute

Target Recruit Count: 107

Registration Number: NCT02404610

Locations: 🇺🇸
Hennepin County Medical Center, Minneapolis, Minnesota, United States

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