Morphine

Generic Name: Morphine

Brand Names: Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₉NO_₃

CAS Number: 57-27-2

Unique Ingredient Identifier: 76I7G6D29C

Background: Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.

Morphine was granted FDA approval in 1941.

Indication: Morphine is used for the management of chronic, moderate to severe pain.

Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.

Associated Conditions: Chronic Pain, Severe Pain

Associated Therapies: -

Clinical Trials

Patient Re-education vs. Background Morphine to IV-PCA in Patient With Unsatisfactory Analgesia Post Laparotomy

Phase 4

Conditions: Post-operative Pain

Interventions: Drug: morphine
Behavioral: Patient re-education

First Posted Date: 2015-08-14

Last Posted Date: 2015-08-17

Lead Sponsor: Clinical Research Centre, Malaysia

Target Recruit Count: 160

Registration Number: NCT02523846

Locations: 🇲🇾
Sultanah Bahiyah Hospital, Alor Seatr, Kedah, Malaysia

IV Paracetamol vs IV Morphine vs Placebo in Sciatalgia

Phase 4

Conditions: Sciatica

Interventions: Drug: Paracetamol
Drug: morphine
Drug: Placebo

First Posted Date: 2015-07-22

Last Posted Date: 2015-07-22

Lead Sponsor: Akdeniz University

Target Recruit Count: 300

Registration Number: NCT02504996

Locations: 🇹🇷
Pamukkale University Hospital, Denizli, Turkey

Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA

Phase 4

Completed

Conditions: Acute Postoperative Pain

Interventions: Drug: Hydromorphone
Drug: Morphine

First Posted Date: 2015-06-26

Last Posted Date: 2017-07-31

Lead Sponsor: University of Erlangen-Nürnberg Medical School

Target Recruit Count: 50

Registration Number: NCT02483221

Locations: 🇩🇪
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Bavaria, Germany

Femoral Nerve Block Compared to Exparel in Total Knee Replacement

Phase 3

Conditions: Pain
Osteoarthritis

Interventions: Drug: Femoral Nerve Block Bupivacaine
Drug: Exparel
Drug: Toradol
Drug: Morphine Sulfate

First Posted Date: 2015-06-16

Last Posted Date: 2016-03-17

Lead Sponsor: The New England Baptist Hospital

Target Recruit Count: 312

Registration Number: NCT02473198

Locations: 🇺🇸
New England Baptist Hospital, Boston, Massachusetts, United States

2 Dose Neuraxial Morphine for Prevention of PDPH

Phase 4

Suspended

Conditions: Postdural Puncture Headache

Interventions: Drug: Morphine
Drug: Sterile normal saline

First Posted Date: 2015-06-16

Last Posted Date: 2023-09-13

Lead Sponsor: Columbia University

Target Recruit Count: 400

Registration Number: NCT02473276

Locations: 🇺🇸
New York Presbyterian Hospital, New York, New York, United States
🇺🇸
Rutgers University Medical School, Newark, New Jersey, United States
🇺🇸
Weill Cornell Medical Center, New York, New York, United States

and more 1 locations