Morphine
- Generic Name
- Morphine
- Brand Names
- Arymo, Avinza, Doloral, Duramorph, Embeda, Infumorph, Kadian, M-ediat, M-eslon, MSIR, Mitigo, Ms Contin, Statex
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19NO3
- CAS Number
- 57-27-2
- Unique Ingredient Identifier
- 76I7G6D29C
- Background
Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone.
Morphine was granted FDA approval in 1941.
- Indication
Morphine is used for the management of chronic, moderate to severe pain.
Opiods, including morphine, are effective for the short term management of pain. Patients taking opioids long term may need to be monitored for the development of physical dependence, addiction disorder, and drug abuse.
- Associated Conditions
- Chronic Pain, Severe Pain
- Associated Therapies
- -
To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine
- Conditions
- Interventions
- First Posted Date
- 2015-05-12
- Last Posted Date
- 2017-05-09
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 200
- Registration Number
- NCT02440399
- Locations
- 🇮🇱
Haemek Medical Center, Afula, Israel
Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers
- Conditions
- Interventions
- First Posted Date
- 2015-05-06
- Last Posted Date
- 2016-08-03
- Lead Sponsor
- Makerere University
- Target Recruit Count
- 240
- Registration Number
- NCT02434939
- Locations
- 🇺🇬
Sickle Cell clinic, Mulago Hospital Complex, Kampala, Uganda
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
- Conditions
- Interventions
- First Posted Date
- 2015-05-06
- Last Posted Date
- 2015-05-06
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT02435537
Comparing Ketamine and Morphine in the Treatment of Acute Fracture Pain
- First Posted Date
- 2015-04-30
- Last Posted Date
- 2019-05-22
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 13
- Registration Number
- NCT02430818
- Locations
- 🇺🇸
Barnes Jewish Hospital, Saint Louis, Missouri, United States
Anti Emetic Efficacy of Combination of Ramosetron and Premixture of Naloxone With Patient-controlled Analgesia
- Conditions
- Interventions
- First Posted Date
- 2015-04-14
- Last Posted Date
- 2016-02-22
- Lead Sponsor
- Kyungpook National University Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT02416115
Ropivacaine Through Continuous Infusion Versus Epidural Morphine for Postoperative Analgesia After Emergency Cesarean Section
- First Posted Date
- 2015-04-07
- Last Posted Date
- 2022-11-08
- Lead Sponsor
- University Hospital, Grenoble
- Target Recruit Count
- 101
- Registration Number
- NCT02410317
- Locations
- 🇫🇷
Hôpital Couple Enfant - CHU de Grenoble, Grenoble, France
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine
- Conditions
- Interventions
- First Posted Date
- 2015-03-31
- Last Posted Date
- 2017-05-30
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 30
- Registration Number
- NCT02403830
- Locations
- 🇺🇸
University of Florida, Jacksonville, Florida, United States
is There an Alternative to Ultrasound Guided Interscalene Block?
- Conditions
- Interventions
- First Posted Date
- 2015-03-24
- Last Posted Date
- 2015-03-24
- Lead Sponsor
- Tunisian Military Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02397330
Ultrasound Guided Femoral Nerve Block
- Conditions
- Interventions
- First Posted Date
- 2015-03-06
- Last Posted Date
- 2024-04-03
- Lead Sponsor
- Beth Israel Deaconess Medical Center
- Target Recruit Count
- 60
- Registration Number
- NCT02381717
- Locations
- 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
🇺🇸St. Vincent's Hospital, Worcester, Massachusetts, United States
The Effects of Morphine on Desflurane Consumption and Recovery Time
- First Posted Date
- 2015-02-12
- Last Posted Date
- 2015-12-03
- Lead Sponsor
- Baskent University
- Target Recruit Count
- 90
- Registration Number
- NCT02362022
- Locations
- 🇹🇷
Baskent University School of Medicine Adana Teaching and Research Hospital, Adana, Turkey
Drug Development Updates
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