Lidocaine

Generic Name
Lidocaine
Brand Names
Agoneaze, Akten, Alivio, Anestacon, Anodyne Lpt, Astero, Band-aid Hurt-free, Cathejell, Curacaine, Depo-medrol With Lidocaine, Dermacinrx Lido V Pak, Dermacinrx Phn Pak, Dermacinrx Prikaan, Diphen, Emla, Fortacin, Glydo, Instillagel, Kenalog, Lido Bdk, Lido-prilo Caine Pack, Lidocan, Lidodan, Lidoderm, Lidopac, Lidopril, Lidopro, Lidosol, Lidothol, Lidotral, Lignospan, Marcaine, Max-freeze, Medi-derm With Lidocaine, Neo-bex, Octocaine, Octocaine With Epinephrine, Oraqix, P-care, P-care X, Pliaglis, Prilolid, Prizotral, Procomycin, Readysharp Anesthetics Plus Ketorolac, Readysharp-A, Readysharp-p40, Readysharp-p80, Relador, Synera, Triple Antibiotic, Venipuncture Px1, Viadur, Xylocaine, Xylocaine With Epinephrine, Xylocard, Xylonor, Zingo, Ztlido
Drug Type
Small Molecule
Chemical Formula
C14H22N2O
CAS Number
137-58-6
Unique Ingredient Identifier
98PI200987
Background

Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anesthesia for a large variety of surgical procedures . It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding sensations . In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others . As a result, lidocaine is also considered a class Ib anti-arrhythmic agent . Nevertheless, lidocaine's local anesthetic action sees its use in many medical situations or circumstances that may benefit from its action, including the treatment of premature ejaculation .

Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis. It is even included in the World Health Organization's List of Essential Medicines .

Indication

Lidocaine is an anesthetic of the amide group indicated for production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks .

Associated Conditions
Acute Otitis Media (AOM), Anorectal discomfort, Arrhythmia, Back Pain Lower Back, Bacterial Vaginosis (BV), Burns, Cervical Syndrome, Earache, Fissure;Anal, Haemorrhoids, Infection, Inflammatory Reaction caused by ear infection-not otherwise specified, Insect Bites, Joint Pain, Mixed Vaginal Infections, Multiple Myeloma (MM), Myringitis, Neuritis, Osteolysis caused by Bone Tumors, Osteoporosis, Otitis Externa, Pain caused by ear infection-not otherwise specified, Pain, Inflammatory, Postherpetic Neuralgia, Primary Hyperparathyroidism (PHPT), Rheumatic Diseases, Rheumatic Joint Disease, Sciatica, Skin Irritation, Soft Tissue Inflammation, Sore Throat, Sunburn, Susceptible infections, Trichomonas Vaginitis, Ulcers, Leg, Urethral Strictures, Ventricular Arrhythmia, Vulvovaginal Candidiasis, Abrasions, Anal discomfort, Cutaneous lesions, Gum pain, Minor burns, Superficial Wounds, Susceptible Bacterial Infections, Ulceration of the mouth, Viral infections of the external ear canal
Associated Therapies
Local Anaesthesia therapy, Post Myocardial Infarction Treatment, Regional Anesthesia therapy

Perioperative Epidural Versus Intravenous Local Anesthetic Infusion in Open Upper Abdominal Surgery

Phase 2
Completed
Conditions
Interventions
First Posted Date
2016-12-29
Last Posted Date
2017-12-07
Lead Sponsor
Assiut University
Target Recruit Count
70
Registration Number
NCT03005171

Intravenous Lidocaine and Postoperative Pain Management

First Posted Date
2016-12-19
Last Posted Date
2016-12-19
Lead Sponsor
Beijing Tongren Hospital
Target Recruit Count
80
Registration Number
NCT02997215
Locations
🇨🇳

Department of Anesthesiology; Beijing Tongren Hospital, Beijing, China

Combination Analgesia for Neonatal Circumcision

First Posted Date
2016-12-13
Last Posted Date
2017-06-29
Lead Sponsor
American University of Beirut Medical Center
Target Recruit Count
70
Registration Number
NCT02990364

Conscious Sedation for Epilepsy Surgery

First Posted Date
2016-12-09
Last Posted Date
2020-10-09
Lead Sponsor
Menoufia University
Target Recruit Count
60
Registration Number
NCT02988050

The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy

First Posted Date
2016-11-21
Last Posted Date
2017-09-12
Lead Sponsor
University Hospital, Lille
Target Recruit Count
135
Registration Number
NCT02969733
Locations
🇫🇷

CHRU, Hôpital Claude Huriez, Lille, France

Neuromas as the Cause of Pain

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-10-12
Last Posted Date
2019-02-08
Lead Sponsor
Danish Pain Research Center
Target Recruit Count
12
Registration Number
NCT02930551
Locations
🇩🇰

Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark

Intravenous Lidocaine for Cystectomy Procedures

First Posted Date
2016-10-05
Last Posted Date
2022-03-09
Lead Sponsor
CAMC Health System
Target Recruit Count
50
Registration Number
NCT02924480
Locations
🇺🇸

Urology center of charleston, Charleston, West Virginia, United States

Spinal Morphine in Robotic Assisted Radical Prostatectomy

First Posted Date
2016-10-05
Last Posted Date
2018-08-07
Lead Sponsor
Maasstad Hospital
Target Recruit Count
160
Registration Number
NCT02924974
Locations
🇳🇱

Maasstad Hospital, Rotterdam, Netherlands

© Copyright 2024. All Rights Reserved by MedPath