Fentanyl

Generic Name: Fentanyl

Brand Names: Abstral, Actiq, Duragesic, Effentora, Fentora, Instanyl, Lazanda, Sublimaze, Subsys, PecFent

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₂₈N_₂O

CAS Number: 437-38-7

Unique Ingredient Identifier: UF599785JZ

Background: Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia. Fentanyl is related to other opioids like morphine and oxycodone.

Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin. In 2017, 47600 overdose deaths in the United States involved some opioid (over 2/3 of all overdose deaths). Opioid overdoses kill an average of 11 Canadians daily.

Fentanyl was FDA approved in 1968.

Indication: Fentanyl intravenous or intramuscular injections are indicated for short term analgesia during induction, maintenance, and recovery from general or regional anesthesia. These injections are also used with a neuroleptic for premedication, induction, and as an adjunct to maintenance of anesthesia. Finally, fentanyl intravenous or intramuscular injections are used with oxygen for anesthesia in high risk patients.

Fentanyl sublingual tablets, transmucosal lozenges, buccal tablets, sublingual sprays, transdermal systems, and nasal sprays are indicated for the management of breakthrough pain in opioid tolerant cancer patients who require around the clock pain management.

Associated Conditions: Cancer Related Pain (Breakthrough Pain), Severe, Chronic Pain

Associated Therapies: Anesthetic premedication therapy, Anesthetics Agent, General Anesthesia, Induction of anesthesia therapy, Maintenance of anesthesia therapy, Regional Anesthesia therapy

Clinical Trials

Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery

Not Applicable

Terminated

Conditions: Opioid Use, Unspecified

Interventions: Drug: Fentanyl
Drug: Methadone

First Posted Date: 2016-04-22

Last Posted Date: 2021-06-01

Lead Sponsor: Andrew Waberski

Target Recruit Count: 26

Registration Number: NCT02747875

Locations: 🇺🇸
Children's National Health System, Washington, District of Columbia, United States

Intravenous Propofol and Fentanyl vs Propofol for Sedation in TRUS Biopsy

Phase 4

Completed

Conditions: Pain

Interventions: Other: Control
Drug: Fentanyl
Drug: propofol

First Posted Date: 2016-04-11

Last Posted Date: 2021-09-01

Lead Sponsor: Mahidol University

Target Recruit Count: 124

Registration Number: NCT02733705

Locations: 🇹🇭
Sirilak Suksompong, Bangkok, Thailand

Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound

Phase 2

Completed

Conditions: Conscious Sedation During Procedure
Endobronchial Ultrasound

Interventions: Drug: Midazolam bolus
Drug: Dexmedetomidine
Drug: Rescue midazolam
Other: Saline placebo
Drug: Fentanyl

First Posted Date: 2016-03-18

Last Posted Date: 2017-02-17

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 197

Registration Number: NCT02713191

Locations: 🇮🇳
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Phase 4

Conditions: Post-operative Residual Curarization

Interventions: Drug: Sugammadex
Device: Diaphragm Ultrasonography
Drug: Neostigmine
Device: Neurumuscual monitoring
Drug: Atropine
Drug: Rocuronium
Drug: Fentanyl
Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2016-03-04

Last Posted Date: 2016-10-25

Lead Sponsor: University of Florence

Target Recruit Count: 58

Registration Number: NCT02698969

Locations: 🇮🇹
Azienda Ospdaliero Universitaria Careggi, Florence, Italy

Delirium in Elderly Patients With Trauma of the Hip

Phase 4

Terminated

Conditions: Hip Fractures
Anesthesia

Interventions: Drug: Bupivacaine
Drug: Acetaminophen
Drug: Levobupivacaine
Drug: Diclofenac
Drug: Ropivacaine
Drug: Ibuprofen
Drug: Naproxen
Drug: Dipyrone
Drug: Fentanyl
Drug: Morphine

First Posted Date: 2016-02-23

Last Posted Date: 2023-08-04

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 239

Registration Number: NCT02689024

Locations: 🇳🇱
Meander Medical Center, Amersfoort, Netherlands
🇳🇱
VU Medical Center, Amsterdam, Netherlands
🇳🇱
Academic Medical Center, Amsterdam, Netherlands

and more 2 locations