Tramadol

Generic Name: Tramadol

Brand Names: Conzip, Durela, Qdolo, Ralivia, Ryzolt, Seglentis, Tridural, Ultracet, Ultram, Zytram

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₅NO_₂

CAS Number: 27203-92-5

Unique Ingredient Identifier: 39J1LGJ30J

Background: Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...

Indication: Tramadol is approved for the management of moderate to severe pain in adults.

Tramadol is also used off-label in the treatment of premature ejaculation.

Associated Conditions: Acute Pain, Premature Ejaculation, Severe Pain, Acute, moderate, severe Pain, Moderate Pain

Associated Therapies: -

Clinical Trials

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

Phase 2

Completed

Conditions: Breast Cancer

Interventions: Drug: Sevoflurane
Drug: TIVA-TCI
Drug: Lidocaine
Drug: Acetaminophen
Drug: Tramadol
Drug: Neostigmine
Drug: Atropine
Device: BIS

First Posted Date: 2016-07-21

Last Posted Date: 2019-10-29

Lead Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy

Target Recruit Count: 120

Registration Number: NCT02839668

Locations: 🇷🇴
IOCN Prof Dr I chiricuta, Cluj-Napoca, Romania

Tramadol Versus Celecoxib in Reducing Pain Associated With IUD Insertion

Phase 4

Conditions: Pain

Interventions: Drug: Tramadol
Drug: Celecoxib
Drug: Placebo 2
Drug: Placebo 1
Procedure: IUD

First Posted Date: 2016-07-11

Last Posted Date: 2019-04-08

Lead Sponsor: Cairo University

Target Recruit Count: 210

Registration Number: NCT02827487

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Oral Tramadol Versus Diclofenac For Pain Relief Before Outpatient Hysteroscopy:

Phase 3

Conditions: Pain, Procedure

Interventions: Drug: Placebo
Drug: Tramadol
Drug: Diclofenac

First Posted Date: 2016-05-04

Last Posted Date: 2016-05-04

Lead Sponsor: Ain Shams University

Target Recruit Count: 102

Registration Number: NCT02760888

Locations: 🇪🇬
Ain Shams University, Cairo, Egypt

Tramadol Versus Celecoxib for Reducing Pain During Operative Office Hysteroscopy

Phase 3

Conditions: Hysteroscopy

Interventions: Drug: Celecoxib
Drug: Tramadol
Drug: Placebo 1
Drug: Placebo 2

First Posted Date: 2016-04-13

Last Posted Date: 2016-07-06

Lead Sponsor: Cairo University

Target Recruit Count: 210

Registration Number: NCT02736071

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Tramadol Versus Celecoxib for Reducing Pain During Office Hysteroscopy in Post Menopausal Women

Phase 3

Conditions: Hysteroscopy

Interventions: Drug: Celecoxib
Drug: Placebo 1
Drug: Tramadol
Drug: Placebo 2

First Posted Date: 2016-04-13

Last Posted Date: 2016-07-06

Lead Sponsor: Cairo University

Target Recruit Count: 210

Registration Number: NCT02736019

Locations: 🇪🇬
Cairo University Hospitals, Cairo, Egypt

Study to Compare Gabapentin to Tramadol in Children With Chronic Neuropathic or Mixed Pain

Phase 3

Terminated

Conditions: Chronic Pain

Interventions: Drug: gabapentin
Drug: tramadol
Other: placebo tramadol
Other: placebo gabapentin

First Posted Date: 2016-03-30

Last Posted Date: 2019-10-03

Lead Sponsor: Pharmaceutical Research Management srl

Target Recruit Count: 2

Registration Number: NCT02722603

Locations: 🇩🇪
Universitaets klinikum Erlangen, Erlangen, Germany
🇳🇱
Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands

Pain Management Associated With the Insertion of Jaydess® in Nulliparous Women

Phase 4

Conditions: IUD Insertion Complication

Interventions: Behavioral: Verbal anesthesia
Drug: Tramadol
Device: Jaydess

First Posted Date: 2016-03-11

Last Posted Date: 2016-03-11

Lead Sponsor: Meir Medical Center

Target Recruit Count: 100

Registration Number: NCT02706509

Immune Response of Caudally Administrated Tramadol In Pediatric Lower Abdominal Surgery

Phase 2

Completed

Conditions: Acute Pain

Interventions: Drug: Bupivacaine
Drug: Tramadol

First Posted Date: 2016-03-09

Last Posted Date: 2017-10-19

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02703415

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

Large-scale Prospective Double-blind Randomized Controlled Trial of Pecs II Block for Breast Surgery

Phase 4

Completed

Conditions: Pain, Postoperative
Postoperative Nausea and Vomiting

Interventions: Drug: Levobupivacaine
Drug: NaCl 0.9%
Drug: Sevoflurane
Drug: Propofol
Drug: Sufentanil
Drug: Atracurium
Drug: Paracetamol
Drug: Tramadol
Drug: Piritramide

First Posted Date: 2015-09-09

Last Posted Date: 2016-07-13

Lead Sponsor: GZA Ziekenhuizen Campus Sint-Augustinus

Target Recruit Count: 140

Registration Number: NCT02544282

Locations: 🇧🇪
GZA Sint Augustinus, Wilrijk, Antwerpen, Belgium

The Analgesic Efficacy of Wound Infiltration With Tramadol

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Tramadol

First Posted Date: 2015-08-07

Last Posted Date: 2015-08-07

Lead Sponsor: Yeditepe University Hospital

Target Recruit Count: 60

Registration Number: NCT02518438

Locations: 🇹🇷
Yeditepe University Hospital, Istanbul, Kozyatagı, Turkey

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