Tramadol

Generic Name: Tramadol

Brand Names: Conzip, Durela, Qdolo, Ralivia, Ryzolt, Seglentis, Tridural, Ultracet, Ultram, Zytram

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₂₅NO_₂

CAS Number: 27203-92-5

Unique Ingredient Identifier: 39J1LGJ30J

Background: Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is consider...

Indication: Tramadol is approved for the management of moderate to severe pain in adults.

Tramadol is also used off-label in the treatment of premature ejaculation.

Associated Conditions: Acute Pain, Premature Ejaculation, Severe Pain, Acute, moderate, severe Pain, Moderate Pain

Associated Therapies: -

Clinical Trials

Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries

Recruiting

Conditions: Post Operative Pain

Interventions: Drug: Tramadol Hydrochloride
Drug: Fentanyl injection

First Posted Date: 2023-08-14

Last Posted Date: 2024-02-28

Lead Sponsor: Zagazig University

Target Recruit Count: 132

Registration Number: NCT05990686

Locations: 🇪🇬
Zagazig University , Fuculty of Medicine, Zagazig, Sharquia, Egypt

Effect of Preoperative Tramadol and Naproxen Sodium on Post Operative Pain

Phase 2

Completed

Conditions: Post Operative Pain
Symptomatic Irreversible Pulpitis

Interventions: Drug: Placebo
Drug: Tramadol
Drug: Naproxen Sodium

First Posted Date: 2023-08-08

Last Posted Date: 2024-08-07

Lead Sponsor: Dow University of Health Sciences

Target Recruit Count: 47

Registration Number: NCT05982392

Locations: 🇵🇰
Dow International Dental College, Karachi, Sindh, Pakistan

USG-Guided Infiltration Popliteal Artery Capsule Knee Block Versus Adductor Canal Block Application as Postoperative Analgesia

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Tramadol
Drug: Morfin

First Posted Date: 2023-07-21

Last Posted Date: 2023-07-21

Lead Sponsor: Siirt Training and Research Hospital

Target Recruit Count: 20

Registration Number: NCT05956275

Locations: 🇹🇷
Bolu Abant İzzet Baysal University, Bolu, Turkey

"NSAIDs vs. Opiates: Which is More Effective in Managing Pain in Mild to Moderate Acute Pancreatitis?

Early Phase 1

Recruiting

Conditions: Acute Pancreatitis

Interventions: Drug: Ketorolac
Drug: Tramadol

First Posted Date: 2023-03-06

Last Posted Date: 2023-04-06

Lead Sponsor: Hayatabad Medical Complex

Target Recruit Count: 130

Registration Number: NCT05756504

Locations: 🇵🇰
Hayatabad Medical Complex, Peshawar, Kpk, Pakistan

Compair Efficacy of iv Dexmedetomidine & Tramadol for Post Spinal Shivering in Obs Patients Undergoing Cesarean Section

Phase 2

Not yet recruiting

Conditions: Post Spinal Shivering

Interventions: Drug: Dexmedetomidine injection
Drug: Tramadol

First Posted Date: 2022-11-15

Last Posted Date: 2022-11-15

Lead Sponsor: Sana Bahadur

Target Recruit Count: 100

Registration Number: NCT05616364

Use of Tramadol Intraligamentary Injections

Not Applicable

Completed

Conditions: Pulpitis

Interventions: Drug: Tramadol hydrochloride
Drug: Lidocaine Hydrochloride

First Posted Date: 2022-09-13

Last Posted Date: 2022-12-19

Lead Sponsor: Jamia Millia Islamia

Target Recruit Count: 105

Registration Number: NCT05538052

Locations: 🇮🇳
Faculty of Dentistry, Jamia MIliia Islamia, New Delhi, India

Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.

Phase 4

Completed

Conditions: Symptomatic Irreversible Pulpitis

Interventions: Drug: Diclofenac Sodium
Drug: Piroxicam
Drug: Vitamin E
Drug: Tramadol

First Posted Date: 2022-08-05

Last Posted Date: 2022-08-05

Lead Sponsor: Farjad Zafar

Target Recruit Count: 120

Registration Number: NCT05488925

Locations: 🇵🇰
Department of Operative Dentistry, Baqai Dental College, Baqai Medical University., Karachi, Sindh, Pakistan

Opioid-Free Pain Protocol After Shoulder Arthroplasty

Phase 4

Recruiting

Conditions: Shoulder Arthropathy
Shoulder Pain

Interventions: Drug: Celecoxib
Drug: Pregabalin
Drug: Tramadol
Drug: Dexamethasone
Drug: Acetaminophen
Drug: Ropivicaine
Drug: Epinephrine
Drug: Ketorolac
Drug: Tizanidine
Drug: Magnesium
Drug: Ibuprofen
Drug: Oxycodone Hydrochloride 5 Mg

First Posted Date: 2022-08-05

Last Posted Date: 2024-01-12

Lead Sponsor: Henry Ford Health System

Target Recruit Count: 80

Registration Number: NCT05488847

Locations: 🇺🇸
Henry Ford Health, Detroit, Michigan, United States

Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption in Shoulder Surgery

Not Applicable

Completed

Conditions: Postoperative Pain Management

Interventions: Drug: Tramadol
Drug: Paracetamol
Drug: Ibuprofen

First Posted Date: 2022-06-02

Last Posted Date: 2023-08-18

Lead Sponsor: Bezmialem Vakif University

Target Recruit Count: 2

Registration Number: NCT05401916

Locations: 🇹🇷
Muhittin Calim, Istanbul, Fatih, Turkey

A Clinical Trial Evaluating the Efficacy and Safety of HSK21542 in Patients for Postoperative Pain Treatment

Phase 3

Completed

Conditions: Postoperative Analgesia

Interventions: Drug: HSK21542 Injection
Drug: placebo
Drug: Tramadol hydrochloride

First Posted Date: 2022-05-25

Last Posted Date: 2023-04-04

Lead Sponsor: Haisco Pharmaceutical Group Co., Ltd.

Target Recruit Count: 387

Registration Number: NCT05390905

Locations: 🇨🇳
Union Hospital, Tongji Medical College, Huazhong U, Wuhan, China

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