Ephedrine
- Generic Name
- Ephedrine
- Brand Names
- Akovaz, Bronkaid, Corphedra, Emerphed, Primatene, Rezipres
- Drug Type
- Small Molecule
- Chemical Formula
- C10H15NO
- CAS Number
- 299-42-3
- Unique Ingredient Identifier
- GN83C131XS
- Background
Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with pseudoephedrine. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepinephrine from sympathetic neurons, inhibiting norepinephrine reuptake and displacing more norepinephrine from storage vesicles. Ephedrine is used for its vasoconstrictive, positive chronotropic, and positive inotropic effects. Ephedrine and phenylephrine are still used to treat hypotension, but their use in other indications has decreased due to the development of more selective adrenergic agonists. Ephedrine was granted a type 7 FDA Approval on 29 April 2016.
- Indication
Ephedrine intravenous injections are indicated to treat hypotension under anesthesia, ephedrine injections by multiple routes are indicated to treat allergic conditions such as bronchial asthma, ephedrine nasal spray is and OTC medication used as a decongestant.
- Associated Conditions
- Allergic Reaction, Bronchial Asthma, Common Cold, Cough, Depression, Fever, General Anesthesia Induced Hypotension, Headache, Joint Pain, Myasthenia Gravis, Narcolepsy, Nasal Congestion, Rhinorrhoea, Sore Throat, Dry cough
- Associated Therapies
- -
Preoperative Ephedrine Attenuates the Hemodynamic Responses of Propofol During Valve Surgery: A Dose Dependent Study
- Conditions
- HypotensionValve Surgery
- Interventions
- First Posted Date
- 2009-11-03
- Last Posted Date
- 2020-09-02
- Lead Sponsor
- King Faisal University
- Target Recruit Count
- 150
- Registration Number
- NCT01006863
- Locations
- 🇪🇬
Mansoura University Hospitals, Mansoura, DK, Egypt
🇸🇦King Fahd Hospital of the University, Dammam, Eastern, Saudi Arabia
Ephedrine for the Treatment of Congenital Myasthenia
- Conditions
- Myasthenic Syndromes, Congenital
- First Posted Date
- 2007-10-10
- Last Posted Date
- 2007-10-10
- Lead Sponsor
- Hadassah Medical Organization
- Target Recruit Count
- 15
- Registration Number
- NCT00541216
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel, Jerusalem, Israel
Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
- Conditions
- PreeclampsiaHypotension
- Interventions
- First Posted Date
- 2007-04-09
- Last Posted Date
- 2022-06-02
- Lead Sponsor
- Northwestern University
- Target Recruit Count
- 110
- Registration Number
- NCT00458003
- Locations
- 🇺🇸
Northwestern University, Chicago, Illinois, United States
🇺🇸Northwestern Memorial Hospital, Chicago, Illinois, United States
"Pecos" B-adrenergic and PPAR-G Stimulation Upregulates Lipid Metabolism in Human Subcutaneous Fat
- Conditions
- Obesity
- First Posted Date
- 2006-09-19
- Last Posted Date
- 2016-01-25
- Lead Sponsor
- Pennington Biomedical Research Center
- Target Recruit Count
- 96
- Registration Number
- NCT00377975
- Locations
- 🇺🇸
Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States
Drug Development Updates
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