Hydromorphone

Generic Name
Hydromorphone
Brand Names
Dilaudid, Exalgo, Hydromorph Contin, Hydromorphone Hp Forte
Drug Type
Small Molecule
Chemical Formula
C17H19NO3
CAS Number
466-99-9
Unique Ingredient Identifier
Q812464R06
Background

Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of morphine that has been available clinically since 1920. Structurally, hydromorphone derived from morphine in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 and 8. Due to these modifications, it present...

Indication

Hydromorphone is indicated for the management of moderate to severe acute pain and severe chronic pain. Due to its addictive potential and overdose risk, hydromorphone is only prescribed when other first-line treatments have failed.
...

Associated Conditions
Neuropathic Pain, Refractory Chronic Cough, Moderate to severe pain
Associated Therapies
-
Clinical Trials
Related News

Spinal Morphine vs. Hydromorphone for Pain Control After Cesarean Delivery

First Posted Date
2016-06-03
Last Posted Date
2019-04-25
Lead Sponsor
Mayo Clinic
Target Recruit Count
134
Registration Number
NCT02789410
Locations
🇺🇸

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable
Completed
Conditions
Postoperative Nausea and Vomiting
Interventions
Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron
First Posted Date
2015-12-09
Last Posted Date
2019-03-07
Lead Sponsor
Vanderbilt University
Target Recruit Count
27034
Registration Number
NCT02625181
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

First Posted Date
2015-11-10
Last Posted Date
2021-09-23
Lead Sponsor
Stanford University
Target Recruit Count
120
Registration Number
NCT02601027
Locations
🇺🇸

Stanford University Medical Center, Stanford, California, United States

Postoperative Pain Therapy With Hydromorphone TCI-PCA vs. Morphine PCA

Phase 4
Completed
Conditions
Acute Postoperative Pain
Interventions
Drug: Hydromorphone
Drug: Morphine
First Posted Date
2015-06-26
Last Posted Date
2017-07-31
Lead Sponsor
University of Erlangen-Nürnberg Medical School
Target Recruit Count
50
Registration Number
NCT02483221
Locations
🇩🇪

Department of Anesthesiology, University Hospital Erlangen, Erlangen, Bavaria, Germany

Synergistic Effect of Ibuprofen and Hydromorphone for Postoperative Pain

Not Applicable
Completed
Conditions
Breast Cancer
Interventions
Drug: Ibuprofen
Drug: Hydromorphone
First Posted Date
2015-06-03
Last Posted Date
2015-06-03
Lead Sponsor
Samsung Medical Center
Target Recruit Count
90
Registration Number
NCT02461056
Locations
🇰🇷

Samsung medical center, Seoul, Korea, Republic of

Intranasal Hydromorphone for the Treatment of Acute Pain in Children: A Pilot Study.

Phase 2
Completed
Conditions
Pain
Interventions
Drug: Hydromorphone
First Posted Date
2015-05-07
Last Posted Date
2019-05-28
Lead Sponsor
Columbia University
Target Recruit Count
35
Registration Number
NCT02437669
Locations
🇺🇸

Morgan Stanley Children's Hospital, New York, New York, United States

Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine

First Posted Date
2015-03-17
Last Posted Date
2018-08-31
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
127
Registration Number
NCT02389829
Locations
🇺🇸

Montefiore Medical Center--Einstein, Bronx, New York, United States

Study of the Treatment of Experimental Pain in Buprenorphine Maintained Persons With Chronic Musculoskeletal Pain

First Posted Date
2015-02-26
Last Posted Date
2017-09-11
Lead Sponsor
Johns Hopkins University
Target Recruit Count
14
Registration Number
NCT02372591
Locations
🇺🇸

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Nausea in Patients Receiving Hydromorphone vs Oxycodone After Total Hip Replacement Surgery

Phase 4
Completed
Conditions
Nausea
Interventions
Drug: Hydromorphone
Drug: Oxycodone
First Posted Date
2014-11-20
Last Posted Date
2017-11-27
Lead Sponsor
University Health Network, Toronto
Target Recruit Count
200
Registration Number
NCT02295124
Locations
🇨🇦

Toronto Western Hospital, Toronto, Ontario, Canada

Intrathecal Hydromorphone for Labor Analgesia

Not Applicable
Terminated
Conditions
Pregnancy
Interventions
Drug: Hyperbaric bupivacaine
Drug: Hydromorphone
Drug: Fentanyl
First Posted Date
2014-10-29
Last Posted Date
2022-03-18
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
21
Registration Number
NCT02277782
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

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