Sertraline

Generic Name: Sertraline

Brand Names: Zoloft

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₁₇Cl_₂N

CAS Number: 79617-96-2

Unique Ingredient Identifier: QUC7NX6WMB

Background: Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as Citalopram and Fluoxetine. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.

Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.

Indication: Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.

Associated Conditions: Binge Eating Disorder (BED), Bulimia Nervosa, Generalized Anxiety Disorder, Major Depressive Disorder (MDD), Obsessive Compulsive Disorder (OCD), Panic Disorder, Post Traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), Social Anxiety Disorder (SAD)

Clinical Trials

Algorithm Guided Treatment Strategies for Major Depressive Disorder

Phase 4

Conditions: Major Depressive Disorder

Interventions: Drug: Escitalopram
Drug: Fluoxetine
Drug: Mirtazapine
Drug: Citalopram
Other: modified electroconvulsive therapy
Other: repetitive transcranial magnetic stimulation
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Venlafaxine
Drug: Duloxetine
Drug: Bupropion
Drug: Trazodone

First Posted Date: 2013-01-10

Last Posted Date: 2013-01-10

Lead Sponsor: Shanghai Mental Health Center

Target Recruit Count: 1080

Registration Number: NCT01764867

Locations: 🇨🇳
Shanghai Mental Health Center, Shanghai, China

Late-life Depression and Cerebral Perfusion

Not Applicable

Withdrawn

Conditions: Depression

Interventions: Drug: Sertraline

First Posted Date: 2012-12-18

Last Posted Date: 2013-07-31

Lead Sponsor: Vanderbilt University

Registration Number: NCT01751828

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Riluzole Augmentation Pilot in Depression (RAPID) Trial

Phase 2

Terminated

Conditions: Major Depressive Disorder

Interventions: Drug: Riluzole
Drug: Sertraline
Other: placebo

First Posted Date: 2012-10-10

Last Posted Date: 2019-08-28

Lead Sponsor: Brigham and Women's Hospital

Target Recruit Count: 21

Registration Number: NCT01703039

Locations: 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States

Bioequivalence Of Zoloft ODT To Jzoloft In Healthy Japanese Subjects

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: JZoloft
Drug: sertraline ODT

First Posted Date: 2012-10-04

Last Posted Date: 2021-01-27

Lead Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Target Recruit Count: 30

Registration Number: NCT01699724

Locations: 🇯🇵
Pfizer Investigational Site, Hachioji-shi, Tokyo, Japan

Verapamil vs. Sertraline for Vestibular Migraine & Chronic Subjective Dizziness

Phase 1

Completed

Conditions: Vestibular Migraine
Chronic Subjective Dizziness

Interventions: Drug: Sertraline
Drug: Verapamil

First Posted Date: 2012-08-21

Last Posted Date: 2015-08-24

Lead Sponsor: Mayo Clinic

Target Recruit Count: 32

Registration Number: NCT01669304

Locations: 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States

A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients

Completed

Conditions: Posttraumatic Stress Disorder

Interventions: Drug: sertraline (Zoloft)

First Posted Date: 2012-05-30

Last Posted Date: 2021-01-27

Lead Sponsor: Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Target Recruit Count: 123

Registration Number: NCT01607593

Locations: 🇯🇵
KURUME University School of Medicine, Kurume-city, Fukuoka, Japan
🇯🇵
National Defense Medical College/Department of Psychiatry, Tokorozawa-city, Saitama, Japan
🇯🇵
Hyogo Institute for Traumatic Stress, Chuo-ku,Kobe-city, Hyogo, Japan

and more 1 locations

The Treatment of Traumatised Refugees With Sertraline Versus Venlafaxine in Combination With Psychotherapy

Phase 4

Completed

Conditions: Post Traumatic Stress Disorder
Depression

Interventions: Drug: Venlafaxine
Drug: Sertraline

First Posted Date: 2012-04-03

Last Posted Date: 2015-03-04

Lead Sponsor: Charlotte Sonne

Target Recruit Count: 207

Registration Number: NCT01569685

Locations: 🇩🇰
Competence Center for Transcultural Psychiatry, Gentofte, Denmark

PROlonGed ExpoSure Sertraline

Phase 4

Completed

Conditions: Posttraumatic Stress Disorder

Interventions: Drug: Sertraline
Behavioral: Prolonged Exposure Therapy

First Posted Date: 2012-02-01

Last Posted Date: 2018-02-28

Lead Sponsor: VA Ann Arbor Healthcare System

Target Recruit Count: 223

Registration Number: NCT01524133

Locations: 🇺🇸
Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, United States
🇺🇸
VA San Diego Healthcare System, San Diego, California, United States
🇺🇸
Ralph H. Johnson VA Medical Center/Savannah Primary Care Clinic, Savannah, Georgia, United States

and more 1 locations