Tropisetron

Generic Name: Tropisetron

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₀N_₂O_₂

CAS Number: 89565-68-4

Unique Ingredient Identifier: 6I819NIK1W

Background: Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.

Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal side effects are rare upon using tropisetron.

Indication: For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.

Associated Conditions: Chemotherapy-Induced Nausea and Vomiting

Clinical Trials

Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer

Phase 3

Completed

Conditions: Cervical Cancer
Nasopharyngeal Cancer
Chemotherapy-induced Nausea and Vomiting
Radiation-Induced Nausea and Vomiting
Antiemetic

Interventions: Drug: Fosaprepitant
Drug: tropisetron
Drug: Dexamethasone

First Posted Date: 2022-10-03

Last Posted Date: 2024-02-06

Lead Sponsor: Shantou University Medical College

Target Recruit Count: 116

Registration Number: NCT05564286

Locations: 🇨🇳
Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China

Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

Phase 4

Completed

Conditions: Nausea and Vomiting

Interventions: Other: normal saline
Drug: metoclopramide
Drug: tropisetron
Drug: dexamethasone

First Posted Date: 2022-09-09

Last Posted Date: 2024-04-02

Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Target Recruit Count: 200

Registration Number: NCT05533281

Locations: 🇨🇳
The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China

A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surgery

Phase 4

Conditions: Postoperative Cognitive Dysfunction
Postoperative Delirium

Interventions: Drug: Placebos
Drug: Tropisetron

First Posted Date: 2019-12-11

Last Posted Date: 2022-01-05

Lead Sponsor: Beijing Chao Yang Hospital

Target Recruit Count: 72

Registration Number: NCT04195204

Locations: 🇨🇳
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium

Phase 4

Conditions: Postoperative Delirium
Emergence Delirium

Interventions: Drug: Placebos
Drug: Tropisetron

First Posted Date: 2019-07-22

Last Posted Date: 2020-03-11

Lead Sponsor: Beijing Chao Yang Hospital

Target Recruit Count: 1508

Registration Number: NCT04027751

Locations: 🇨🇳
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron

First Posted Date: 2015-12-09

Last Posted Date: 2019-03-07

Lead Sponsor: Vanderbilt University

Target Recruit Count: 27034

Registration Number: NCT02625181

Locations: 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States

A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation

Phase 4

Conditions: Vomiting

Interventions: Drug: Tropisetron
Drug: Dexamethasone
Drug: Aprepitant

First Posted Date: 2015-10-15

Last Posted Date: 2016-12-30

Lead Sponsor: Jun Zhu

Target Recruit Count: 130

Registration Number: NCT02576327

Comparative Effect Study Between Distal-proximal Point Association and Local Distribution Point Association in Chemotherapy-induced Nausea and Vomiting

Not Applicable

Conditions: Chemotherapy-induced Nausea and Vomiting

Interventions: Drug: only antiemetic (Ramosetron, Tropisetron and dexamethasone)
Other: Matching points ST36+CV12 plus antiemetic drug
Other: Matching points PC6+CV12 plus antiemetic drug
Other: Matching points CV13+CV12 plus antiemetic drug

First Posted Date: 2015-06-23

Last Posted Date: 2015-06-23

Lead Sponsor: Tianjin University of Traditional Chinese Medicine

Target Recruit Count: 240

Registration Number: NCT02478047

Locations: 🇨🇳
Tianjin University of TCM, Tianjin, Tianjin, China

Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Device: Transcutaneous electrical acupoint stimulation
Device: Sham transcutaneous electrical acupoint stimulation
Drug: Dexamethasone
Drug: Tropisetron