Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography

Phase 4

Completed

Conditions: Heart Valve Disease
Heart Septal Defects, Atrial

Interventions: Drug: Ketofol(ketamine+propofol)
Drug: Dexmedetomidine

First Posted Date: 2016-08-16

Last Posted Date: 2017-11-06

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 50

Registration Number: NCT02867930

Locations: 🇮🇳
Postgraduate Institute of Medical Education and Research, Chandigarh, India

Scalp Block Versus Scalp Infiltration With Dexmedetomidine and Local Anesthetic for Post Craniotomy Pain

Phase 2

Completed

Conditions: Headache

Interventions: Procedure: scalp block
Procedure: infiltration
Drug: Dexmedetomidine
Drug: Bupivacaine

First Posted Date: 2016-08-15

Last Posted Date: 2016-08-15

Lead Sponsor: NAVNEH SAMAGH

Target Recruit Count: 150

Registration Number: NCT02866409

Intrathecal Dexmedetomidine Versus Fentanyl With Bupivacaine in Children Undergoing Major Abdominal Cancer Surgery

Phase 2

Conditions: Intrathecal Dexmedetomidine
Pediatric Cancer Surgery

Interventions: Drug: Bupivacaine
Drug: Fentanyl
Drug: Dexmedetomidine

First Posted Date: 2016-08-10

Last Posted Date: 2018-04-10

Lead Sponsor: South Egypt Cancer Institute

Target Recruit Count: 60

Registration Number: NCT02861716

Locations: 🇪🇬
South Egypt Cancer Institute, Assuit, Egypt

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

Phase 2

Completed

Conditions: Sleep
Anesthesia
Postoperative Delirium

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2016-08-05

Last Posted Date: 2023-03-20

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 469

Registration Number: NCT02856594

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery

Phase 4

Completed

Conditions: Elective Penile Surgeries
Hypospadias
Urethral Fistula or Stricture After Hypospadias Repair
Penile Curvature

Interventions: Drug: plain ropivacaine
Drug: Dexmedetomidine
Drug: Ropivacaine

First Posted Date: 2016-07-28

Last Posted Date: 2018-07-17

Lead Sponsor: Yonsei University

Target Recruit Count: 40

Registration Number: NCT02848157

Locations: 🇰🇷
Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of