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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress

Phase 3
Completed
Conditions
Abdominal Cancer
Interventions
Drug: Ketamine
Drug: Dexmedetomidine
Drug: Bupivacaine
First Posted Date
2016-10-07
Last Posted Date
2018-01-09
Lead Sponsor
Assiut University
Target Recruit Count
90
Registration Number
NCT02927379
Locations
🇪🇬

South Egypt Cancer Instuite, Assuit, Egypt

Whether Dexmedetomidine Can Improve the Prognosis of Elderly Patients With Postoperative Cognitive Dysfunction

Phase 4
Completed
Conditions
Postoperative Cognitive Dysfunction
Postoperative Delirium
Interventions
Drug: Dexmedetomidine
Drug: Saline
Drug: Sufentanyl
First Posted Date
2016-10-04
Last Posted Date
2023-07-20
Lead Sponsor
Zhejiang Cancer Hospital
Target Recruit Count
240
Registration Number
NCT02923128
Locations
🇨🇳

Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

Effect of Dexmedetomidine on Stress Response and Emergence Agitation During Laparoscopic Surgery

Phase 2
Completed
Conditions
Stress Response
Interventions
Drug: Dexmedetomidine
First Posted Date
2016-09-28
Last Posted Date
2017-01-04
Lead Sponsor
Assiut University
Target Recruit Count
90
Registration Number
NCT02917018
Locations
🇪🇬

Assiut university hospital, Assiut, Egypt

Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair

Phase 4
Withdrawn
Conditions
Cleft Palate
Interventions
Drug: Dexmedetomidine
Drug: Placebo
First Posted Date
2016-09-26
Last Posted Date
2019-02-05
Lead Sponsor
Baylor College of Medicine
Registration Number
NCT02915042

Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU

Phase 4
Terminated
Conditions
Deep Sedation
Ventilators, Mechanical
Critical Illness
Interventions
Drug: Midazolam
Drug: Propofol
Drug: Dexmedetomidine
First Posted Date
2016-09-16
Last Posted Date
2020-07-13
Lead Sponsor
Duke University
Target Recruit Count
7
Registration Number
NCT02903407
Locations
🇺🇸

Duke University Medical Center, Durham, North Carolina, United States

Dexmedetomidine in Pediatric Cardiac Surgery

Not Applicable
Completed
Conditions
Acute Kidney Injury
Interventions
Drug: Dexmedetomidine
Drug: normal saline
First Posted Date
2016-09-05
Last Posted Date
2020-07-28
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
144
Registration Number
NCT02888275
Locations
🇰🇷

Jin-Tae Kim, Seoul, Korea, Republic of

Post- Thoracotomy Paravertebral Block

Phase 2
Completed
Conditions
Pain, Postoperative
Interventions
Drug: Bupivacaine
Drug: Dexmedetomidine
First Posted Date
2016-09-01
Last Posted Date
2018-12-04
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT02886429
Locations
🇪🇬

Faculty of Medicine, Assiut, Egypt

Dexmedetomidine to Treat Bariatric Surgery-associated Pain

Phase 3
Completed
Conditions
Obesity
Interventions
Drug: Dexmedetomidine
Drug: Fentanyl
Drug: Morphine
First Posted Date
2016-08-26
Last Posted Date
2021-12-07
Lead Sponsor
Janelle Vaughns
Target Recruit Count
26
Registration Number
NCT02880540
Locations
🇺🇸

Childrens National Medical Center, Washington, District of Columbia, United States

Dexmedetomidine vs Midazolam for Intraoperative Sedation

Phase 4
Completed
Conditions
Failed Moderate Sedation During Procedure
Minimally Conscious State
Interventions
Drug: Dexmedetomidine
Drug: Midazolam
First Posted Date
2016-08-25
Last Posted Date
2017-08-22
Lead Sponsor
Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Target Recruit Count
120
Registration Number
NCT02878837
Locations
🇧🇷

Hospital do Servidor Publico Estadual, Sao Paulo, Sao Paulo SP, Brazil

The Neuroprotective Effects of Dexmedetomidine During Brain Surgery

Not Applicable
Completed
Conditions
Brain Tumor
Cerebrovascular Disorders
Interventions
Drug: Dexmedetomidine
First Posted Date
2016-08-25
Last Posted Date
2020-09-22
Lead Sponsor
National Taiwan University Hospital
Target Recruit Count
160
Registration Number
NCT02878707
Locations
🇨🇳

National Taiwan University Hospital, Taipei, Taiwan

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