Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Ketamine vs. Placebo as Adjunctive Therapies for Severe Alcohol Withdrawal

Phase 4

Withdrawn

Conditions: Alcohol Withdrawal

Interventions: Drug: Ketamine
Drug: Dexmedetomidine
Drug: Normal saline

First Posted Date: 2016-07-06

Last Posted Date: 2018-01-19

Lead Sponsor: University of Colorado, Denver

Registration Number: NCT02823977

Locations: 🇺🇸
University of Colorado Hospital, Aurora, Colorado, United States

Intraperitoneal Analgesia in Pediatric Laparoscopy

Phase 2

Completed

Conditions: Analgesia

Interventions: Drug: Magnesium Sulfate
Drug: Normal saline 0.9 %
Drug: Dexmedetomidine

First Posted Date: 2016-07-01

Last Posted Date: 2020-01-03

Lead Sponsor: Assiut University

Target Recruit Count: 97

Registration Number: NCT02820610

Locations: 🇪🇬
Faculty of Medicine Assuit University, Asyut, Assuit, Egypt

Analgesia in Knee Arthroscopic Surgery

Phase 2

Completed

Conditions: Postoperative Pain

Interventions: Drug: Dexmedetomidine
Drug: Saline
Drug: Dexamethasone

First Posted Date: 2016-06-30

Last Posted Date: 2017-06-27

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02818985

Locations: 🇪🇬
Seham Mohamed Moeen Ibrahim, Asyut, Egypt

Self-management of Sedative Therapy by Ventilated Patients

Phase 2

Active, not recruiting

Conditions: Critical Illness
Anxiety
Respiratory Failure

Interventions: Drug: Dexmedetomidine

First Posted Date: 2016-06-30

Last Posted Date: 2024-07-29

Lead Sponsor: Mayo Clinic

Target Recruit Count: 190

Registration Number: NCT02819141

Locations: 🇺🇸
School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States
🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States