Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Dexmedetomidine Sedation and Cardiopulmonary Bypass

Phase 2

Completed

Conditions: Coronary Artery Bypass Grafting

Interventions: Drug: propofol
Drug: Dexmedetomidine

First Posted Date: 2016-04-04

Last Posted Date: 2016-09-27

Lead Sponsor: Assiut University

Target Recruit Count: 100

Registration Number: NCT02727621

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

Bioavailability of Subcutaneous Dexmedetomidine

Phase 4

Completed

Conditions: Pain

Interventions: Drug: Dexmedetomidine

First Posted Date: 2016-03-31

Last Posted Date: 2017-09-12

Lead Sponsor: Turku University Hospital

Target Recruit Count: 10

Registration Number: NCT02724098

Locations: 🇫🇮
Perioperative Services, Intensive Care and Pain Therapy, Turku University Hospital, Turku, Finland

Transbucal Dexmedetomidine for Prevention of Sevoflurane Emergence Agitation in Pre-school Children

Phase 2

Completed

Conditions: Agitation

Interventions: Drug: saline
Drug: Dexmedetomidine

First Posted Date: 2016-03-28

Last Posted Date: 2020-07-14

Lead Sponsor: Assiut University

Target Recruit Count: 90

Registration Number: NCT02720705

Locations: 🇪🇬
Assiut university hospitals, Assiut, Egypt

Dexmedetomidine for Cesarean Section

Phase 1

Completed

Conditions: Cesarean Section, Affecting Fetus or Newborn

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2016-03-22

Last Posted Date: 2017-03-28

Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Target Recruit Count: 40

Registration Number: NCT02715154

Locations: 🇨🇳
The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

Effect Of Dexmedetomidine On Sublingual Microcirculation In Patients Undergoing On Pump CABG Surgery

Phase 4

Conditions: Sublingual Microcirculation

Interventions: Drug: Placebo for Dexmedetomidine normal saline infusion
Drug: Dexmedetomidine
Drug: Propofol infusion

First Posted Date: 2016-03-21

Last Posted Date: 2018-01-24

Lead Sponsor: Cairo University

Target Recruit Count: 70

Registration Number: NCT02714725

Locations: 🇪🇬
Kasr Al-Ainy hospitals , Faculty of medicine , Cairo university, Cairo, Egypt

Dexmedetomidine vs. Midazolam Sedation for Endobronchial Ultrasound

Phase 2

Completed

Conditions: Conscious Sedation During Procedure
Endobronchial Ultrasound

Interventions: Drug: Midazolam bolus
Drug: Dexmedetomidine
Drug: Rescue midazolam
Other: Saline placebo
Drug: Fentanyl

First Posted Date: 2016-03-18

Last Posted Date: 2017-02-17

Lead Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Target Recruit Count: 197

Registration Number: NCT02713191

Locations: 🇮🇳
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Effect of Dexmedetomidine on Pacemaker Function Following Cardiac Surgery

Withdrawn

Conditions: Congenital Heart Disease

Interventions: Drug: Dexmedetomidine

First Posted Date: 2016-03-15

Last Posted Date: 2019-03-28

Lead Sponsor: Nationwide Children's Hospital

Registration Number: NCT02709200

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient

Phase 4

Completed

Conditions: Kidney Disease

Interventions: Drug: Dexmedetomidine

First Posted Date: 2016-03-14

Last Posted Date: 2020-12-17

Lead Sponsor: National Taiwan University Hospital

Target Recruit Count: 60

Registration Number: NCT02707809

Locations: 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan

Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery

Not Applicable

Conditions: Infective Endocarditis

Interventions: Drug: Normal saline
Drug: dexmedetomidine

First Posted Date: 2016-03-04

Last Posted Date: 2019-01-15

Lead Sponsor: Yonsei University

Target Recruit Count: 94

Registration Number: NCT02698930

Locations: 🇰🇷
Department of Anaesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Dexmedetomidine Use in ICU Sedation and Postoperative Recovery in Elderly Patients and Post-cardiac Surgery

Not Applicable

Conditions: Delirium
Cognitive Decline
Post-operative Quality of Recovery

Interventions: Drug: propofol
Drug: Dexmedetomidine

First Posted Date: 2016-03-04

Last Posted Date: 2016-11-03

Lead Sponsor: University of British Columbia

Target Recruit Count: 70

Registration Number: NCT02699801

Locations: 🇨🇦
Vancouver General Hospital, Vancouver, British Columbia, Canada

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