Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Cognitive Functions After TIVA With Dexmedetomidine

Phase 4

Completed

Conditions: Postoperative Confusion

Interventions: Drug: Remifentanil
Drug: Propofol
Drug: Rocuronium
Drug: Dexmedetomidine

First Posted Date: 2015-12-16

Last Posted Date: 2024-05-17

Lead Sponsor: Uludag University

Target Recruit Count: 40

Registration Number: NCT02631135

Locations: 🇹🇷
Uludag University, Bursa, Turkey

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

Phase 4

Completed

Conditions: Unconsciousness
Anesthesia

Interventions: Drug: Placebo
Drug: Dexmedetomidine
Drug: Propofol
Drug: S-ketamine
Drug: Sevoflurane

First Posted Date: 2015-12-08

Last Posted Date: 2017-03-27

Lead Sponsor: University of Turku

Target Recruit Count: 160

Registration Number: NCT02624401

Locations: 🇫🇮
Turku PET Centre, Turku, Finland

Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks

Phase 4

Completed

Conditions: Post-thoracotomy Pain Syndrome

Interventions: Drug: Ropivacaine
Drug: Dexmedetomidine
Device: Mindray M7 series

First Posted Date: 2015-12-02

Last Posted Date: 2015-12-02

Lead Sponsor: Weifeng Tu

Target Recruit Count: 60

Registration Number: NCT02619513

Locations: 🇨🇳
Department of Anesthesiology，Guangzhou Military Region General Hospital, Guangzhou, Guangdong, China

Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection

Phase 4

Completed

Conditions: Opioid-Related Disorders
Neuralgia

Interventions: Drug: Dexmedetomidine
Drug: Lidocaine
Other: placebo
Drug: Fentanyl

First Posted Date: 2015-11-30

Last Posted Date: 2016-10-11

Lead Sponsor: University Medical Centre Ljubljana

Target Recruit Count: 60

Registration Number: NCT02616523

Dexmedetomidine Versus Propofol for Prolonged Sedation in Poly Traumatized Mechanically Ventilated Patients

Phase 2

Completed

Conditions: Trauma

Interventions: Drug: Propofol
Drug: Dexmedetomidine

First Posted Date: 2015-11-17

Last Posted Date: 2016-08-23

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT02606409

Locations: 🇪🇬
Assiut university hospitals, Assiut, Assiut governorate, Egypt

The Effect of Dexmedetomidine on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery

Not Applicable

Completed

Conditions: Acute Kidney Injury(Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery)

Interventions: Drug: saline
Drug: dexmedetomidine

First Posted Date: 2015-11-17

Last Posted Date: 2019-09-09

Lead Sponsor: Yonsei University

Target Recruit Count: 108

Registration Number: NCT02607163

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of