Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure

Phase 3

Completed

Conditions: Lack of Drug Action

Interventions: Drug: Magnesium Sulphate
Drug: Dexmedetomidine

First Posted Date: 2016-02-17

Last Posted Date: 2020-10-19

Lead Sponsor: Theodor Bilharz Research Institute

Target Recruit Count: 60

Registration Number: NCT02684019

Locations: 🇪🇬
Theodor Bilharz Research Institute, Giza, Egypt

Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial

Phase 4

Completed

Conditions: Chronic Dissecting Aneurysm of Thoracic Aorta
Chronic Nontraumatic Dissection of Thoracic Aorta
Dissecting Aneurysm of the Thoracic Aorta

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2016-02-10

Last Posted Date: 2019-08-14

Lead Sponsor: Gangnam Severance Hospital

Target Recruit Count: 52

Registration Number: NCT02678728

Locations: 🇰🇷
Gangnam Severance Hospital, Seoul, Korea, Republic of

Dexmedetomidine and Bupivacaine With Bupivacaine in Ultrasonography Guided Fascia Iliaca Compartment Block in Adults

Phase 3

Conditions: Femoral Fractures

Interventions: Drug: Bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2016-01-20

Last Posted Date: 2016-10-13

Lead Sponsor: Hamidreza Mahboobi

Target Recruit Count: 60

Registration Number: NCT02658760

Locations: 🇮🇷
Shahid Mohammadi hospital, Bandar Abbas, Hormozgan, Iran, Islamic Republic of

the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block

Phase 4

Completed

Conditions: Opioid Use, Unspecified

Interventions: Drug: Ropivacaine
Drug: Dexmedetomidine
Drug: Dexamethasone

First Posted Date: 2016-01-12

Last Posted Date: 2020-07-22

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 105

Registration Number: NCT02653144

Locations: 🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Dexmedetomidine and Ketamine in MRI

Phase 1

Completed

Conditions: Magnetic Resonance Imaging

Interventions: Drug: Dexmedetomidine
Drug: Ketamine

First Posted Date: 2016-01-12

Last Posted Date: 2019-07-24

Lead Sponsor: Children's Hospital Medical Center, Cincinnati

Target Recruit Count: 22

Registration Number: NCT02652507

Locations: 🇺🇸
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Dexmedetomidine and Desflurane Consumption

Not Applicable

Completed

Conditions: Anesthesia

Interventions: Drug: Placebo
Drug: Dexmedetomidine
Procedure: Ondansetron
Procedure: fentanyl
Procedure: propofol
Procedure: Atracurium
Procedure: diclofenac sodium
Procedure: desflurane

First Posted Date: 2016-01-11

Last Posted Date: 2016-11-10

Lead Sponsor: Theodor Bilharz Research Institute

Target Recruit Count: 40

Registration Number: NCT02652312

Locations: 🇪🇬
Theodor Bilharz Research Institute, Giza, Egypt

Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Not Applicable

Completed

Conditions: Arthroplasty, Replacement

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2016-01-07

Last Posted Date: 2018-06-13

Lead Sponsor: Yonsei University

Target Recruit Count: 68

Registration Number: NCT02648958

Locations: 🇰🇷
Severance hospital, Seoul, Korea, Republic of

Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia

Not Applicable

Completed

Conditions: Rotator Cuff Tear

Interventions: Drug: normal saline
Drug: Dexmedetomidine

First Posted Date: 2015-12-30

Last Posted Date: 2019-01-25

Lead Sponsor: Yonsei University

Target Recruit Count: 80

Registration Number: NCT02643017

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of