Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

The Effect of Obesity in Dexmedetomidine Metabolic Clearance

Phase 4

Conditions: Obesity

Interventions: Drug: Dexmedetomidine

First Posted Date: 2015-09-23

Last Posted Date: 2016-10-12

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 40

Registration Number: NCT02557867

Locations: 🇨🇱
Hospital Clinico Pontificia Universidad Catolica, Santiago, Región metropolitana, Chile

Dexmedetomidine Sedation in Children With Respiratory Morbidities

Completed

Conditions: Respiratory Morbidity

First Posted Date: 2015-09-21

Last Posted Date: 2015-09-21

Lead Sponsor: Universitair Ziekenhuis Brussel

Target Recruit Count: 19

Registration Number: NCT02555605

Locations: 🇧🇪
Universitair Ziekenhuis Brussel, Brussels, Vlaams Brabant, Belgium

Dexmedetomidine or Dexmedetomidine Combined With Dexamethasone on Postoperative Nausea and Vomiting in Breast Cancer

Not Applicable

Completed

Conditions: Postoperative Nausea and Vomiting

Interventions: Drug: Control
Drug: Dexmedetomidine and dexamethasone
Drug: Dexmedetomidine

First Posted Date: 2015-09-16

Last Posted Date: 2020-08-24

Lead Sponsor: Gachon University Gil Medical Center

Target Recruit Count: 150

Registration Number: NCT02550795

Infraclavicular Perineural Dexmedetomidine

Not Applicable

Completed

Conditions: The Analgesic Effects

Interventions: Drug: Bupivacaine
Drug: Dexmedetomidine

First Posted Date: 2015-09-16

Last Posted Date: 2017-02-28

Lead Sponsor: Cukurova University

Target Recruit Count: 60

Registration Number: NCT02550782

Locations: 🇹🇷
Erzincan Üniversity, Erzincan, Merkez, Turkey

Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery

Phase 4

Conditions: Pituitary Neoplasms

Interventions: Drug: Sodium Chloride 0.9%
Drug: Dexmedetomidine

First Posted Date: 2015-09-15

Last Posted Date: 2016-10-12

Lead Sponsor: Pontificia Universidad Catolica de Chile

Target Recruit Count: 40

Registration Number: NCT02549768

Locations: 🇨🇱
Division de Anestesia - Pontificia Universidad Catolica de Chile, Santiago, Region Metropolitana, Chile

Dexmedetomidine Versus Propofol for Prolonged Sedation in Critically Ill Trauma and Surgical Patients

Phase 4

Completed

Conditions: Delirium

Interventions: Drug: Dexmedetomidine

First Posted Date: 2015-09-14

Last Posted Date: 2015-09-14

Lead Sponsor: University of Tennessee Graduate School of Medicine

Target Recruit Count: 57

Registration Number: NCT02548923

Locations: 🇺🇸
University of Tennessee Medical Center, Knoxville, Tennessee, United States

Postoperative Analgesic Effects of Using Dexmedetomidine for Ultrasound Guided Thoracic Paravertebral Block

Phase 4

Completed

Conditions: Pain

Interventions: Drug: serum physiologic
Drug: bupivacaine
Drug: dexmedetomidin

First Posted Date: 2015-09-09

Last Posted Date: 2016-08-03

Lead Sponsor: TC Erciyes University

Target Recruit Count: 93

Registration Number: NCT02544893

Locations: 🇹🇷
Erciyes University Medicine Faculty, Kayseri, Turkey

Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty

Phase 3

Conditions: Osteoarthritis
Knee Arthroplasty
Pain Management

Interventions: Procedure: Periarticular
Procedure: Motor free
Procedure: Motor free with dex
Drug: Ropivacaine
Drug: epinephrine
Drug: morphine
Drug: Ketorolac
Drug: Dexmedetomidine
Drug: saline

First Posted Date: 2015-09-03

Last Posted Date: 2016-11-15

Lead Sponsor: Lawson Health Research Institute

Target Recruit Count: 135

Registration Number: NCT02540070

Locations: 🇨🇦
University Hospital, London Health Sciences Centre, London, Ontario, Canada

Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery

Not Applicable

Completed

Conditions: Lung Cancer
Video-assisted Thoracoscopic Surgery

Interventions: Drug: Normal saline
Drug: Dexmedetomidine

First Posted Date: 2015-09-01

Last Posted Date: 2015-11-11

Lead Sponsor: Yonsei University

Target Recruit Count: 111

Registration Number: NCT02537249

Locations: 🇰🇷
Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Dexmedetomidine for Non-invasive Ventilation After Chest Trauma

Phase 4

Completed

Conditions: Thoracic Injuries

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2015-09-01

Last Posted Date: 2017-03-09

Lead Sponsor: University Hospital, Grenoble

Target Recruit Count: 20

Registration Number: NCT02537366

Locations: 🇫🇷
CHU de Grenoble, Grenoble, France

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