Dexmedetomidine

Generic Name: Dexmedetomidine

Brand Names: Dexdor, Igalmi, Precedex, Dexmedetomidine Accord

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆N_₂

CAS Number: 113775-47-6

Unique Ingredient Identifier: 67VB76HONO

Background: An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication: Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions: Agitation, Alcohol Withdrawal Syndrome

Associated Therapies: -

Clinical Trials

Effects of Dexmedetomidine on Delirium After Living Donor Renal Transplantation in Adult Patients

Phase 4

Conditions: Postoperative Delirium After Living Donor Renal Transplantation

Interventions: Drug: Dexmedetomidine
Drug: Saline

First Posted Date: 2015-07-28

Last Posted Date: 2018-06-12

Lead Sponsor: Tao Zhang

Target Recruit Count: 100

Registration Number: NCT02509949

Locations: 🇨🇳
First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China

Dexmedetomidine Addition to Benzodiazepines for Patients With Alcohol Withdrawal State in the ICU

Phase 4

Completed

Conditions: Alcohol Withdrawal State

Interventions: Drug: Dexmedetomidine

First Posted Date: 2015-07-14

Last Posted Date: 2015-07-14

Lead Sponsor: Bogomolets National Medical University

Target Recruit Count: 70

Registration Number: NCT02496650

Stress Response and Neurodevelopmental Outcome After Cardiac Surgery Utilizing CPB in Children: A Prospective, Double Blinded and Randomized Study

Phase 2

Active, not recruiting

Conditions: Congenital Heart Disease

Interventions: Drug: Placebo
Drug: Dexmedetomidine

First Posted Date: 2015-07-08

Last Posted Date: 2024-06-20

Lead Sponsor: Aymen N Naguib

Target Recruit Count: 30

Registration Number: NCT02492269

Locations: 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States

Echocardiographic Evaluation of the Effects of Dexmedetomidine in Diastolic Dysfunction

Not Applicable

Completed

Conditions: Under General Anesthesia

Interventions: Drug: normal saline(Saline 0.9%)
Drug: Dexmedetomidine

First Posted Date: 2015-07-03

Last Posted Date: 2015-08-10

Lead Sponsor: Yonsei University

Target Recruit Count: 40

Registration Number: NCT02490072

Locations: 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of