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Dexmedetomidine

Generic Name
Dexmedetomidine
Brand Names
Dexdor, Igalmi, Precedex, Dexmedetomidine Accord
Drug Type
Small Molecule
Chemical Formula
C13H16N2
CAS Number
113775-47-6
Unique Ingredient Identifier
67VB76HONO
Background

An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine.

Indication

Administered intravenously, dexmedetomidine is indicated for the sedation of initially intubated and mechanically ventilated patients during treatment in intensive care settings, and for the sedation of non-intubated patients prior to and/or during surgery and other procedures. It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.

Associated Conditions
Agitation, Alcohol Withdrawal Syndrome
Associated Therapies
-
Clinical Trials
Related News

Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-

Not Applicable
Completed
Conditions
Prostate Cancer
Robotic Surgery
Interventions
Drug: Saline
Drug: Dexmedetomidine
First Posted Date
2015-08-31
Last Posted Date
2016-01-29
Lead Sponsor
Yonsei University
Target Recruit Count
50
Registration Number
NCT02536014
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine, Seoul, Korea, Republic of

The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia

Phase 4
Conditions
Spinal Diseases
Local Anesthesia
Interventions
Drug: Dexmedetomidine
Drug: normal saline
Drug: Lidocaine
Drug: Low-dose Dexmedetomidine
Drug: Moderate-dose Dexmedetomidine
Drug: High-dose Dexmedetomidine
First Posted Date
2015-08-28
Last Posted Date
2015-08-28
Lead Sponsor
Tang-Du Hospital
Target Recruit Count
212
Registration Number
NCT02535273

Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia

Early Phase 1
Completed
Conditions
Hypoxic-ischemic Encephalopathy
Interventions
Drug: Dexmedetomidine
First Posted Date
2015-08-20
Last Posted Date
2017-01-12
Lead Sponsor
Seattle Children's Hospital
Target Recruit Count
7
Registration Number
NCT02529202
Locations
🇺🇸

Seattle Children's Hospital, Seattle, Washington, United States

Midazolam Used Alone or Sequential Use of Midazolam and Propofol/Dexmedetomidine in Mechanically Ventilated Patients

Phase 4
Conditions
Mechanical Ventilation
Complication
Delirium
Interventions
Drug: midazolam
Drug: Fentanyl
Drug: midazolam(used for passing the SBT safety screen)
Drug: propofol
Drug: Dexmedetomidine
First Posted Date
2015-08-19
Last Posted Date
2016-04-28
Lead Sponsor
West China Hospital
Target Recruit Count
240
Registration Number
NCT02528513
Locations
🇨🇳

Department of Critical care medicine of West China Hospital, Chengdu, Sichuan, China

Dexmedetomidine in Children Having Transthoracic Echocardiography

Phase 4
Completed
Conditions
Heart Disease
Interventions
Drug: Chloral Hydrate
Drug: Dexmedetomidine
Drug: Placebo
First Posted Date
2015-08-14
Last Posted Date
2017-07-31
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
279
Registration Number
NCT02523144
Locations
🇨🇳

Shanghai Children's Hospital, Shanghai, China

Chronotropic Incompetence in Patients With HFpEF

Not Applicable
Completed
Conditions
Heart Failure
Interventions
Other: Static Handgrip
Drug: Dexmedetomidine
Drug: Glycopyrrolate
Drug: Isoproterenol
First Posted Date
2015-08-14
Last Posted Date
2020-08-06
Lead Sponsor
University of Texas Southwestern Medical Center
Target Recruit Count
40
Registration Number
NCT02524145
Locations
🇺🇸

The Institute for Exercise and Environmental Medicine, Dallas, Texas, United States

Anticholinergic Premedication for Sedation With Dexmedetomidine During Spinal Anesthesia

Phase 4
Completed
Conditions
Bradycardia
Interventions
Drug: Atropine
Drug: Dexmedetomidine
Drug: Ephedrine
First Posted Date
2015-08-13
Last Posted Date
2016-01-18
Lead Sponsor
Sira Bang
Target Recruit Count
120
Registration Number
NCT02522858
Locations
🇰🇷

Inje University Seoul Paik Hospital, Seoul, Korea, Seoul, Jung-Gu,, Korea, Republic of

Memory Modulation by Pain During Anesthesia

Phase 1
Completed
Conditions
Amnesia
Anesthesia
Pain
Interventions
Drug: Dexmedetomidine
Drug: Midazolam
Device: Peripheral nerve stimulation
Drug: Ketamine
First Posted Date
2015-08-05
Last Posted Date
2020-07-01
Lead Sponsor
University of Pittsburgh
Target Recruit Count
32
Registration Number
NCT02515890
Locations
🇺🇸

University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Isoflurane-induced Neuroinflammation in Children With Hydrocephalus

Phase 3
Terminated
Conditions
Hydrocephalus
Toxicity
Interventions
Drug: Isoflurane
Drug: Dexmedetomidine
First Posted Date
2015-07-31
Last Posted Date
2018-12-13
Lead Sponsor
Nationwide Children's Hospital
Target Recruit Count
25
Registration Number
NCT02512809

Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism

Phase 4
Conditions
Diabetes
Interventions
Drug: placebo
Drug: Dexmedetomidine
First Posted Date
2015-07-29
Last Posted Date
2015-07-29
Lead Sponsor
Shaanxi Provincial People's Hospital
Target Recruit Count
120
Registration Number
NCT02510612
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